PMID- 24668467 OWN - NLM STAT- MEDLINE DCOM- 20140826 LR - 20220408 IS - 0171-2004 (Print) IS - 0171-2004 (Linking) VI - 220 DP - 2014 TI - NGF, BDNF, NT3, and NT4. PG - 3-15 LID - 10.1007/978-3-642-45106-5_1 [doi] AB - The discovery of nerve growth factor (NGF) was a seminal event in history of research in developmental neurobiology. The further discovery that NGF was just one of a family of structurally similar growth factors, neurotrophins, provided important insights into the way nerve cells communicate, during development of the nervous system, and in neuroplasticity, memory, and learning in the adult nervous system. Four neurotrophins, NGF, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT3), and neurotrophin-4 (NT4), regulate a wide variety of neural functions, acting upon p75NTR, TrkA, TrkB, and TrkC receptors. FAU - Bothwell, M AU - Bothwell M AD - University of Washington, Seattle, WA, USA, mab@uw.edu. LA - eng PT - Journal Article PT - Review PL - Germany TA - Handb Exp Pharmacol JT - Handbook of experimental pharmacology JID - 7902231 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Nerve Growth Factors) RN - 0 (Neurotrophin 3) RN - 9061-61-4 (Nerve Growth Factor) RN - P658DCA9XD (neurotrophin 4) SB - IM MH - Animals MH - Brain-Derived Neurotrophic Factor/physiology MH - Evolution, Molecular MH - Humans MH - Nerve Growth Factor/physiology MH - Nerve Growth Factors/chemistry/genetics/*physiology MH - Neurotrophin 3/physiology EDAT- 2014/03/29 06:00 MHDA- 2014/08/27 06:00 CRDT- 2014/03/27 06:00 PHST- 2014/03/27 06:00 [entrez] PHST- 2014/03/29 06:00 [pubmed] PHST- 2014/08/27 06:00 [medline] AID - 10.1007/978-3-642-45106-5_1 [doi] PST - ppublish SO - Handb Exp Pharmacol. 2014;220:3-15. doi: 10.1007/978-3-642-45106-5_1.