PMID- 24668482
OWN - NLM
STAT- MEDLINE
DCOM- 20140826
LR  - 20140326
IS  - 0171-2004 (Print)
IS  - 0171-2004 (Linking)
VI  - 220
DP  - 2014
TI  - Neurotrophic factors in spinal cord injury.
PG  - 443-60
LID - 10.1007/978-3-642-45106-5_16 [doi]
AB  - A major challenge in repairing the injured spinal cord is to assure survival of 
      damaged cells and to encourage regrowth of severed axons. Because neurotrophins 
      are known to affect these processes during development, many experimental 
      approaches to improving function of the injured spinal cord have made use of 
      these agents, particularly Brain derived neurotrophic factor (BDNF) and 
      Neurotrophin-3 (NT-3). More recently, neurotrophins have also been shown to 
      affect the physiology of cells and synapses in the spinal cord. The effect of 
      neurotrophins on circuit performance adds an important dimension to their 
      consideration as agents for repairing the injured spinal cord. In this chapter we 
      discuss the role of neurotrophins in promoting recovery after spinal cord injury 
      from both a structural and functional perspective.
FAU - Boyce, Vanessa S
AU  - Boyce VS
AD  - Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, 
      11794-5230, USA.
FAU - Mendell, Lorne M
AU  - Mendell LM
LA  - eng
GR  - 5 R01 NS16996/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - Germany
TA  - Handb Exp Pharmacol
JT  - Handbook of experimental pharmacology
JID - 7902231
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Animals
MH  - Axons/physiology
MH  - Cell Survival
MH  - Humans
MH  - Nerve Growth Factors/*physiology
MH  - Recovery of Function
MH  - Spinal Cord Injuries/*physiopathology
MH  - Synapses/physiology
EDAT- 2014/03/29 06:00
MHDA- 2014/08/27 06:00
CRDT- 2014/03/27 06:00
PHST- 2014/03/27 06:00 [entrez]
PHST- 2014/03/29 06:00 [pubmed]
PHST- 2014/08/27 06:00 [medline]
AID - 10.1007/978-3-642-45106-5_16 [doi]
PST - ppublish
SO  - Handb Exp Pharmacol. 2014;220:443-60. doi: 10.1007/978-3-642-45106-5_16.