PMID- 24668725
OWN - NLM
STAT- MEDLINE
DCOM- 20150420
LR  - 20150615
IS  - 1613-4133 (Electronic)
IS  - 1613-4125 (Linking)
VI  - 58
IP  - 8
DP  - 2014 Aug
TI  - Targeting mitochondrial alterations to prevent type 2 diabetes--evidence from 
      studies of dietary redox-active compounds.
PG  - 1739-49
LID - 10.1002/mnfr.201300747 [doi]
AB  - As a growing epidemic, type 2 diabetes mellitus (T2DM) has significantly affected 
      the individual's quality of life and economy of the society. Understanding the 
      mechanisms of the disease and discovery of new therapeutic options has become 
      more urgent than ever before. Mitochondrial alterations (e.g. functional 
      alterations, and impaired biogenesis and dynamics) are strongly associated with 
      the development of T2DM. Accumulation of reactive oxygen species or intermediates 
      of incomplete fatty acid oxidation due to mitochondrial deficiency activates 
      stress kinases and dampens insulin signaling. Redox-active compounds such as 
      resveratrol, pyrroloquinoline quinone, and hydroxytyrosol can potently counteract 
      reactive oxygen species, and improve mitochondrial function and biogenesis. 
      Therefore, targeting the mitochondrial alterations with these redox-active 
      compounds may lead to new therapeutic or preventive options for T2DM. In this 
      article, we review the molecular mechanisms of mitochondrial alterations in T2DM, 
      and the action of redox-active compounds to reverse mitochondrial changes and 
      oxidative stress in T2DM. In addition, the current challenges and future 
      directions are discussed and prospected.
CI  - (c) 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Cheng, Zhiyong
AU  - Cheng Z
AD  - Department of Human Nutrition, Foods and Exercise, Fralin Translational Obesity 
      Research Center, Virginia Tech Center for Drug Discovery, College of Agriculture 
      and Life Science, Virginia Tech, VA, USA.
FAU - Schmelz, Eva M
AU  - Schmelz EM
FAU - Liu, Dongmin
AU  - Liu D
FAU - Hulver, Matthew W
AU  - Hulver MW
LA  - eng
GR  - 1R01AT007077/AT/NCCIH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140212
PL  - Germany
TA  - Mol Nutr Food Res
JT  - Molecular nutrition & food research
JID - 101231818
RN  - 0 (Antioxidants)
SB  - IM
MH  - Animals
MH  - Antioxidants/*therapeutic use
MH  - Diabetes Mellitus, Type 2/metabolism/*prevention & control
MH  - *Diet
MH  - *Evidence-Based Medicine
MH  - Humans
MH  - Mitochondria/*metabolism
MH  - *Models, Biological
MH  - Oxidation-Reduction
MH  - *Oxidative Stress
MH  - Signal Transduction
OTO - NOTNLM
OT  - Hydroxytyrosol
OT  - Mitochondria
OT  - Pyrroloquinoline quinone
OT  - Resveratrol
OT  - Type 2 diabetes mellitus
EDAT- 2014/03/29 06:00
MHDA- 2015/04/22 06:00
CRDT- 2014/03/27 06:00
PHST- 2013/10/09 00:00 [received]
PHST- 2013/12/13 00:00 [revised]
PHST- 2014/01/01 00:00 [accepted]
PHST- 2014/03/27 06:00 [entrez]
PHST- 2014/03/29 06:00 [pubmed]
PHST- 2015/04/22 06:00 [medline]
AID - 10.1002/mnfr.201300747 [doi]
PST - ppublish
SO  - Mol Nutr Food Res. 2014 Aug;58(8):1739-49. doi: 10.1002/mnfr.201300747. Epub 2014 
      Feb 12.