PMID- 24669260
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 7
IP  - 4
DP  - 2014 Apr
TI  - Correlation between single nucleotide polymorphisms of the ACTA2 gene and 
      coronary artery stenosis in patients with type 2 diabetes mellitus.
PG  - 970-976
AB  - This study aimed to analyze the correlation between single nucleotide 
      polymorphisms (SNPs) of the actin, aortic smooth muscle (ACTA2) gene and coronary 
      artery stenosis in patients with type 2 diabetes mellitus (T2DM). Eight SNPs from 
      the promoter region of the ACTA2 gene were screened. Patients with T2DM (n=251) 
      were divided into two groups, those with severe coronary stenosis (SCS(+) group; 
      n=168) and those without severe coronary stenosis (SCS(-) group; n=83). Patients 
      were also divided according to lesion branching into those whose lesions involved 
      less than three branches (LCA(-) group) and those whose lesions involved at least 
      three branches (LCA(+) group). The clinical and laboratory data of the patients 
      were collected, and the genotyping of eight SNPs was conducted followed by 
      statistical analysis. Of the eight SNPs, only the rs1324551 SNP was identified to 
      be significantly different between the SCS(+) and SCS(-) groups (P<0.05). The 
      frequency of the rs1324551 G allele and GG genotype in the SCS(+) group was 
      significantly higher than that of the SCS(-) group (P=0.044 and P=0.001, 
      respectively). No significant difference was observed between the LCA(-) and 
      LCA(+) groups. Following the deduction of age, gender and traditional risk 
      factors, the odds ratios of the GG genotype in additive and recessive models were 
      2.93 [95% confidence interval (CI), 1.05-8.19; P=0.04] and 2.34 (95% CI, 
      1.09-5.02; P=0.03), respectively, and this relevancy was represented only in 
      patients with low insulin levels. Age and smoking were also found to increase the 
      risk of coronary artery lesions. In conclusion, the rs1324551 SNP in the promoter 
      region of the ACTA2 gene was identified to be independently correlated with the 
      degree of coronary artery stenosis in patients with T2DM and plasma insulin may 
      inhibit coronary artery stenosis during the pathogenic process.
FAU - Fang, Hui
AU  - Fang H
AD  - Department of Cardiology, Institute of War Surgery, The Third Affiliated Hospital 
      of Third Military Medical University, Chongqing 400042, P.R. China.
FAU - Luo, Xiaoli
AU  - Luo X
AD  - Department of Cardiology, Institute of War Surgery, The Third Affiliated Hospital 
      of Third Military Medical University, Chongqing 400042, P.R. China.
FAU - Wang, Yan
AU  - Wang Y
AD  - Department of Medical Genetics, Third Military Medical University, Chongqing 
      400038, P.R. China.
FAU - Liu, Nian
AU  - Liu N
AD  - Department of Cardiology, Institute of War Surgery, The Third Affiliated Hospital 
      of Third Military Medical University, Chongqing 400042, P.R. China.
FAU - Fu, Chunjiang
AU  - Fu C
AD  - Department of Cardiology, Institute of War Surgery, The Third Affiliated Hospital 
      of Third Military Medical University, Chongqing 400042, P.R. China.
FAU - Wang, Hongyong
AU  - Wang H
AD  - Department of Cardiology, Institute of War Surgery, The Third Affiliated Hospital 
      of Third Military Medical University, Chongqing 400042, P.R. China.
FAU - Fang, Yuqiang
AU  - Fang Y
AD  - Department of Cardiology, Institute of War Surgery, The Third Affiliated Hospital 
      of Third Military Medical University, Chongqing 400042, P.R. China.
FAU - Shi, Weibin
AU  - Shi W
AD  - Department of Cardiology, Institute of War Surgery, The Third Affiliated Hospital 
      of Third Military Medical University, Chongqing 400042, P.R. China.
FAU - Zhang, Ye
AU  - Zhang Y
AD  - Department of Cardiology, Institute of War Surgery, The Third Affiliated Hospital 
      of Third Military Medical University, Chongqing 400042, P.R. China.
FAU - Zeng, Chunyu
AU  - Zeng C
AD  - Department of Cardiology, Institute of War Surgery, The Third Affiliated Hospital 
      of Third Military Medical University, Chongqing 400042, P.R. China.
FAU - Wang, Xukai
AU  - Wang X
AD  - Department of Cardiology, Institute of War Surgery, The Third Affiliated Hospital 
      of Third Military Medical University, Chongqing 400042, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20140128
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC3965172
OTO - NOTNLM
OT  - coronary artery stenosis
OT  - single nucleotide polymorphism
OT  - type 2 diabetes mellitus
EDAT- 2014/03/29 06:00
MHDA- 2014/03/29 06:01
PMCR- 2014/01/28
CRDT- 2014/03/27 06:00
PHST- 2013/08/17 00:00 [received]
PHST- 2014/01/10 00:00 [accepted]
PHST- 2014/03/27 06:00 [entrez]
PHST- 2014/03/29 06:00 [pubmed]
PHST- 2014/03/29 06:01 [medline]
PHST- 2014/01/28 00:00 [pmc-release]
AID - etm-07-04-0970 [pii]
AID - 10.3892/etm.2014.1510 [doi]
PST - ppublish
SO  - Exp Ther Med. 2014 Apr;7(4):970-976. doi: 10.3892/etm.2014.1510. Epub 2014 Jan 
      28.