PMID- 24669683
OWN - NLM
STAT- MEDLINE
DCOM- 20140919
LR  - 20140327
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 27
IP  - 24
DP  - 2013 Dec
TI  - [Expression and methylation status of IGFBP-rP1 gene in laryngocarcinoma].
PG  - 1352-4, 1359
AB  - OBJECTIVE: To investigate the relationship between the promoter methylation and 
      protein expression of insulin-like growth factor binding protein-related protein 
      1(IGFBP-rP1) in laryngeal squamous cell carcinoma (LSCC). METHOD: Methylation 
      specific PCR (MSP) approach and immunohistochemistry methods were used to examine 
      the methylation status and protein expression of IGFBP-rP1 in 45 samples of 
      laryngeal carcinoma and 18 samples of tissues beside cancer. RESULT: For the 
      promoter site, methylation frequency of IGFBP-rP1 in tumor specimens (33.3%, 
      15/45) was significantly higher than that in corresponding normal tissues (5.6%, 
      1/18) (P < 0.05). The protein expression of IGFBP-rP1 in tumor tissues was 
      significantly higher than that in corresponding normal tissues (P < 0.05) and was 
      inversely correlated with its methylation status of promoter. CONCLUSION: 
      Epigenetic silencing of IGFBP-rP1 gene expression by promoter hypermethylation 
      may play an important role in LSCC.
FAU - Hu, Junlan
AU  - Hu J
FAU - Zhao, Ruili
AU  - Zhao R
FAU - Wu, Ganxun
AU  - Wu G
FAU - Wang, Jingtian
AU  - Wang J
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (Insulin-Like Growth Factor Binding Proteins)
RN  - 0 (insulin-like growth factor binding protein-related protein 1)
SB  - IM
MH  - Adenocarcinoma/genetics/*metabolism/pathology
MH  - Aged
MH  - *DNA Methylation
MH  - Female
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Proteins/genetics/*metabolism
MH  - Laryngeal Neoplasms/genetics/*metabolism/pathology
MH  - Male
MH  - Middle Aged
EDAT- 2014/03/29 06:00
MHDA- 2014/09/23 06:00
CRDT- 2014/03/28 06:00
PHST- 2014/03/28 06:00 [entrez]
PHST- 2014/03/29 06:00 [pubmed]
PHST- 2014/09/23 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Dec;27(24):1352-4, 1359.