PMID- 24670128
OWN - NLM
STAT- MEDLINE
DCOM- 20150625
LR  - 20161020
IS  - 1439-7609 (Electronic)
IS  - 1439-7595 (Linking)
VI  - 24
IP  - 6
DP  - 2014 Nov
TI  - Identification of clinical parameters associated with serum oxidative stress in 
      patients with rheumatoid arthritis.
PG  - 926-30
LID - 10.3109/14397595.2014.891495 [doi]
AB  - OBJECTIVES: Reactive oxygen species (ROS) are considered to be involved in the 
      pathobiology of rheumatoid arthritis (RA); however, their association with 
      disease activity has not been elucidated. In this study, we measured reactive 
      oxygen metabolites (ROM) in patients with RA using a new Free Radical Analytical 
      System and determined clinical parameters associated with ROM. METHODS: One 
      hundred and fifty-two patients with RA and 80 patients with diabetes mellitus 
      (DM) were included in this observational study. To measure ROM, the d-ROM test 
      was performed on blood samples drawn from all subjects. The correlation between 
      ROM and biomarkers, disease activity, doses of methotrexate (MTX), and 
      prednisolone (PSL) were investigated. RESULTS: There were significant, positive 
      correlations between ROM and CRP, matrix metalloproteinase 3 (MMP3), Disease 
      Activity Score 28-erythrocyte sedimentation rate (DAS28-ESR), Clinical Disease 
      Activity Index (CDAI), and the Simplified Disease Activity Index (SDAI). Multiple 
      regression analysis revealed that CRP and DAS28-ESR were correlated with ROM. 
      CONCLUSIONS: The serum level of ROM was associated with CRP and DAS28-ESR, 
      suggesting that ROM, in conjunction with CRP and MMP3, may be able to be used as 
      a new biological disease marker to evaluate the disease activity of RA.
FAU - Nakajima, Arata
AU  - Nakajima A
AD  - Department of Orthopedics, Toho University Sakura Medical Center , Sakura, Chiba 
      , Japan.
FAU - Aoki, Yasuchika
AU  - Aoki Y
FAU - Shibata, Yoshifumi
AU  - Shibata Y
FAU - Sonobe, Masato
AU  - Sonobe M
FAU - Terajima, Fumiaki
AU  - Terajima F
FAU - Takahashi, Hiroshi
AU  - Takahashi H
FAU - Saito, Masahiko
AU  - Saito M
FAU - Taniguchi, Shinji
AU  - Taniguchi S
FAU - Yamada, Manabu
AU  - Yamada M
FAU - Nakagawa, Koichi
AU  - Nakagawa K
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20140326
PL  - England
TA  - Mod Rheumatol
JT  - Modern rheumatology
JID - 100959226
RN  - 0 (Antirheumatic Agents)
RN  - 0 (Biomarkers)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antirheumatic Agents/therapeutic use
MH  - Arthritis, Rheumatoid/*blood/diagnosis/drug therapy
MH  - Biomarkers/blood
MH  - Diabetes Mellitus/blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxidative Stress/*physiology
MH  - Reactive Oxygen Species/*blood
MH  - Severity of Illness Index
MH  - Young Adult
OTO - NOTNLM
OT  - Disease activity
OT  - Oxidative stress
OT  - Reactive oxygen metabolites
OT  - Rheumatoid arthritis
EDAT- 2014/03/29 06:00
MHDA- 2015/06/26 06:00
CRDT- 2014/03/28 06:00
PHST- 2014/03/28 06:00 [entrez]
PHST- 2014/03/29 06:00 [pubmed]
PHST- 2015/06/26 06:00 [medline]
AID - 10.3109/14397595.2014.891495 [doi]
PST - ppublish
SO  - Mod Rheumatol. 2014 Nov;24(6):926-30. doi: 10.3109/14397595.2014.891495. Epub 
      2014 Mar 26.