PMID- 24670135
OWN - NLM
STAT- MEDLINE
DCOM- 20150625
LR  - 20161125
IS  - 1439-7609 (Electronic)
IS  - 1439-7595 (Linking)
VI  - 24
IP  - 6
DP  - 2014 Nov
TI  - Weighting with the Lansbury articular index improves the correlation of 
      ultrasound score with serum matrix metalloproteinase-3 level in rheumatoid 
      arthritis patients.
PG  - 915-9
LID - 10.3109/14397595.2014.888794 [doi]
AB  - OBJECTIVE: To determine whether weighting improves the correlation of ultrasound 
      (US) score with serum matrix metalloproteinase-3 (MMP-3) level in rheumatoid 
      arthritis (RA). METHODS: As ultrasound examination was performed on 100 RA 
      patients, and the severity of synovial effusion and synovial hypertrophy and the 
      blood flow were semi-quantitatively graded from 0 to 3 by using the gray-scale 
      (GS) and power Doppler (PD) modes. We then calculated the sums of the scores of 
      the 28 joints of each patient in the 2 modes, that is, the GS28 and PD28 scores, 
      as well as the respective scores weighted using the Lansbury articular index 
      (LAI, shoulder and elbow, x 12; wrist, x 8; and knee, x 24)-Lans GS28 and Lans 
      PD28 scores. RESULT: The Lans PD28 score showed a higher correlation with MMP-3 
      (r = 0.591; 95% confidence interval, 0.446-0.705, p < 0.0001) than the existing 
      measures. The scores of the large joints-the knee, shoulder, and elbow-correlated 
      well with the serum MMP-3 level. CONCLUSION: Weighting with the LAI can improve 
      the correlation of US findings with serum MMP-3 level. Bidirectional approach 
      based on both serum MMP-3 level and US scores can further improve the assessment 
      of disease activity in RA patients.
FAU - Gorai, Misa
AU  - Gorai M
AD  - Department of Internal Medicine and Rheumatology, Juntendo University Faculty of 
      Medicine , Tokyo , Japan.
FAU - Ogasawara, Michihiro
AU  - Ogasawara M
FAU - Matsuki, Yuko
AU  - Matsuki Y
FAU - Yamada, Yusuke
AU  - Yamada Y
FAU - Murayama, Go
AU  - Murayama G
FAU - Sugisaki, Nagachika
AU  - Sugisaki N
FAU - Nemoto, Takuya
AU  - Nemoto T
FAU - Ando, Seiichiro
AU  - Ando S
FAU - Minowa, Kentaro
AU  - Minowa K
FAU - Kon, Takayuki
AU  - Kon T
FAU - Tada, Kurisu
AU  - Tada K
FAU - Matsushita, Masakazu
AU  - Matsushita M
FAU - Yamaji, Ken
AU  - Yamaji K
FAU - Tamura, Naoto
AU  - Tamura N
FAU - Takasaki, Yoshinari
AU  - Takasaki Y
LA  - eng
PT  - Journal Article
DEP - 20140326
PL  - England
TA  - Mod Rheumatol
JT  - Modern rheumatology
JID - 100959226
RN  - 0 (Biomarkers)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Arthritis, Rheumatoid/*blood/*diagnostic imaging
MH  - Biomarkers/blood
MH  - Female
MH  - Humans
MH  - Joints/*diagnostic imaging
MH  - Male
MH  - Matrix Metalloproteinase 3/*blood
MH  - Middle Aged
MH  - Severity of Illness Index
MH  - Synovial Membrane/*diagnostic imaging
MH  - Ultrasonography
MH  - Young Adult
OTO - NOTNLM
OT  - Lansbury articular index
OT  - Matrix metalloproteinase-3
OT  - Rheumatoid arthritis
OT  - Ultrasound
EDAT- 2014/03/29 06:00
MHDA- 2015/06/26 06:00
CRDT- 2014/03/28 06:00
PHST- 2014/03/28 06:00 [entrez]
PHST- 2014/03/29 06:00 [pubmed]
PHST- 2015/06/26 06:00 [medline]
AID - 10.3109/14397595.2014.888794 [doi]
PST - ppublish
SO  - Mod Rheumatol. 2014 Nov;24(6):915-9. doi: 10.3109/14397595.2014.888794. Epub 2014 
      Mar 26.