PMID- 24670326
OWN - NLM
STAT- MEDLINE
DCOM- 20150714
LR  - 20211021
IS  - 1476-5527 (Electronic)
IS  - 0950-9240 (Linking)
VI  - 28
IP  - 12
DP  - 2014 Dec
TI  - Coronary flow velocity reserve is impaired in hypertensive patients with 
      hyperhomocysteinemia.
PG  - 743-7
LID - 10.1038/jhh.2014.22 [doi]
AB  - Hyperhomocysteinemia (HHcy) is an independent risk factor for coronary artery 
      disease. Chronic HHcy induces coronary endothelial injury, and homocysteine (Hcy) 
      inhibits insulin sensitivity by inducing endoplasmic reticulum stress in adipose 
      tissue. However, the combined effects of chronic HHcy and hypertension on 
      coronary artery endothelial function have still remained unclear. Fifty-one 
      patients with essential hypertension (HT) were recruited, and were divided into 
      nHT group (without HHcy) and H-type HT group (with HHcy). Forty healthy subjects 
      were enrolled as controls. We assessed coronary artery endothelial function by 
      coronary flow velocity reserve (CFVR). Hcy levels were significantly higher 
      (15.60+/-6.58 vs 13.08+/-4.13 mumol l(-1), P<0.05), whereas CFVR values were 
      significantly lower in the HT patients than in the control group (2.88+/-0.70 vs 
      3.23+/-0.54, P<0.05). Hcy levels were negatively correlated with CFVR value 
      (r=-0.578, P<0.01, 95% confidence interval -0.085 to -0.046). The homeostasis 
      model assessment-insulin resistance values were significantly higher (3.92+/-2.16 
      vs 2.72+/-1.50, P<0.05) , whereas CFVR values were significantly lower in H-type HT 
      group than in nHT group (2.31+/-0.31 vs 3.25+/-0.62, P<0.01). Coronary artery 
      endothelial function may be impaired in essential hypertensive patients with 
      HHcy, and insulin resistance induced by HHcy may contribute to this damage.
FAU - Liu, J
AU  - Liu J
AD  - Department of Endocrinology, Beijing Chaoyang Hospital Affiliated to Capital 
      Medical University, Beijing, People's Republic of China.
FAU - Xu, Y
AU  - Xu Y
AD  - Department of Endocrinology, Beijing Chaoyang Hospital Affiliated to Capital 
      Medical University, Beijing, People's Republic of China.
FAU - Zhang, H
AU  - Zhang H
AD  - Department of Endocrinology, Beijing Chaoyang Hospital Affiliated to Capital 
      Medical University, Beijing, People's Republic of China.
FAU - Gao, X
AU  - Gao X
AD  - Department of Endocrinology, Beijing Chaoyang Hospital Affiliated to Capital 
      Medical University, Beijing, People's Republic of China.
FAU - Fan, H
AU  - Fan H
AD  - Department of Endocrinology, Beijing Chaoyang Hospital Affiliated to Capital 
      Medical University, Beijing, People's Republic of China.
FAU - Wang, G
AU  - Wang G
AD  - Department of Endocrinology, Beijing Chaoyang Hospital Affiliated to Capital 
      Medical University, Beijing, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140327
PL  - England
TA  - J Hum Hypertens
JT  - Journal of human hypertension
JID - 8811625
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Blood Flow Velocity/physiology
MH  - Coronary Vessels/*physiopathology
MH  - Endothelium, Vascular/physiopathology
MH  - Female
MH  - Homocysteine/blood
MH  - Humans
MH  - Hyperhomocysteinemia/*complications
MH  - Hypertension/*complications/*physiopathology
MH  - Insulin Resistance
MH  - Male
MH  - Middle Aged
MH  - Regression Analysis
EDAT- 2014/03/29 06:00
MHDA- 2015/07/15 06:00
CRDT- 2014/03/28 06:00
PHST- 2013/10/21 00:00 [received]
PHST- 2014/02/06 00:00 [revised]
PHST- 2014/02/19 00:00 [accepted]
PHST- 2014/03/28 06:00 [entrez]
PHST- 2014/03/29 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - jhh201422 [pii]
AID - 10.1038/jhh.2014.22 [doi]
PST - ppublish
SO  - J Hum Hypertens. 2014 Dec;28(12):743-7. doi: 10.1038/jhh.2014.22. Epub 2014 Mar 
      27.