PMID- 24670490
OWN - NLM
STAT- MEDLINE
DCOM- 20150413
LR  - 20190918
IS  - 1881-1736 (Electronic)
IS  - 0030-154X (Linking)
VI  - 90
IP  - 3
DP  - 2013
TI  - Differential effects of neonatal maternal separation on the expression of 
      neurotrophic factors in rat brain. II: Regional differences in the cerebellum 
      versus the cerebral cortex.
PG  - 53-8
AB  - This study was conducted in order to examine the effects of early postnatal 
      maternal separation stress on the age-dependent fluctuations in the expression 
      levels of neurotrophic factor ligands and receptors in the developing cerebellum. 
      Wistar rats were separated from their mothers for 3 h each day during postnatal 
      days (PND) 10 to 15. The expression level of mRNA for brain-derived neurotrophic 
      factor (BDNF), tyrosine kinase receptor B (TrkB), insulin-like growth factor-1 
      (IGF-1), and type-1 IGF receptor (IGF-1R) were evaluated in the cerebellum on 
      PND16, 20, 30, and 60 with real-time RT-PCR. The mRNA levels of cerebellar BDNF 
      in maternally separated rats were increased on PND16, while the other variables 
      showed no significant alterations at any of the time points examined. However, 
      the effects of an identical maternal separation on the cerebral cortex were 
      previously reported to be completely different. These results indicate regional 
      differences in the responses of neurotrophic factor ligands/receptors between the 
      cerebellum and cerebral cortex. Given that neurotrophic factors play important 
      roles in brain development, alterations in these factors may interrupt normal 
      brain development and ultimately, lead to functional disruptions.
FAU - Miki, Takanori
AU  - Miki T
AD  - Departments of Anatomy and Neurobiology, Kagawa University.
FAU - Lee, Kyoung-Youl
AU  - Lee KY
FAU - Yokoyama, Toshifumi
AU  - Yokoyama T
FAU - Liu, Jun-Qian
AU  - Liu JQ
FAU - Kusaka, Takashi
AU  - Kusaka T
FAU - Suzuki, Shingo
AU  - Suzuki S
FAU - Ohta, Ken-ichi
AU  - Ohta K
FAU - Warita, Katsuhiko
AU  - Warita K
FAU - Jamal, Mostofa
AU  - Jamal M
FAU - Ueki, Masaaki
AU  - Ueki M
FAU - Yakura, Tomiko
AU  - Yakura T
FAU - Hosomi, Naohisa
AU  - Hosomi N
FAU - Takeuchi, Yoshiki
AU  - Takeuchi Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Okajimas Folia Anat Jpn
JT  - Okajimas folia anatomica Japonica
JID - 0401014
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Cerebellum/*metabolism
MH  - Cerebral Cortex/*metabolism
MH  - Female
MH  - *Maternal Deprivation
MH  - Nerve Growth Factors/*metabolism
MH  - Pregnancy
MH  - Random Allocation
MH  - Rats, Wistar
EDAT- 2013/01/01 00:00
MHDA- 2015/04/14 06:00
CRDT- 2014/03/28 06:00
PHST- 2014/03/28 06:00 [entrez]
PHST- 2013/01/01 00:00 [pubmed]
PHST- 2015/04/14 06:00 [medline]
AID - DN/JST.JSTAGE/ofaj/90.53 [pii]
AID - 10.2535/ofaj.90. [doi]
PST - ppublish
SO  - Okajimas Folia Anat Jpn. 2013;90(3):53-8. doi: 10.2535/ofaj.90..