PMID- 24670553 OWN - NLM STAT- MEDLINE DCOM- 20151214 LR - 20211021 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 9 IP - 3 DP - 2014 TI - The associations between serum brain-derived neurotrophic factor, potential confounders, and cognitive decline: a longitudinal study. PG - e91339 LID - 10.1371/journal.pone.0091339 [doi] LID - e91339 AB - Brain-derived neurotrophic factor (BDNF) plays a role in the maintenance and function of neurons. Although persons with Alzheimer's disease have lower cortical levels of BDNF, evidence regarding the association between circulating BDNF and cognitive function is conflicting. We sought to determine the correlates of BDNF level and whether BDNF level was prospectively associated with cognitive decline in healthy older adults. We measured serum BDNF near baseline in 912 individuals. Cognitive status was assessed repeatedly with the modified Mini-Mental Status Examination and the Digit Symbol Substitution test over the next 10 years. We evaluated the association between BDNF and cognitive decline with longitudinal models. We also assessed the association between BDNF level and demographics, comorbidities and health behaviors. We found an association between serum BDNF and several characteristics that are also associated with dementia (race and depression), suggesting that future studies should control for these potential confounders. We did not find evidence of a longitudinal association between serum BDNF and subsequent cognitive test trajectories in older adults, although we did identify a potential trend toward a cross-sectional association. Our results suggest that serum BDNF may have limited utility as a biomarker of prospective cognitive decline. FAU - Nettiksimmons, Jasmine AU - Nettiksimmons J AD - Department of Psychiatry, University of California San Francisco, San Francisco, California, United States of America. FAU - Simonsick, Eleanor M AU - Simonsick EM AD - Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, United States of America. FAU - Harris, Tamara AU - Harris T AD - Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America. FAU - Satterfield, Suzanne AU - Satterfield S AD - Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America. FAU - Rosano, Caterina AU - Rosano C AD - Center for Aging and Population Health, Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America. FAU - Yaffe, Kristine AU - Yaffe K AD - Departments of Psychiatry, Neurology, and Epidemiology and Biostatistics, University of California San Francisco, San Francisco Veterans Affairs Medical Center, San Francisco, California, United States of America. CN - Health ABC Study LA - eng GR - P30 AG024827/AG/NIA NIH HHS/United States GR - R01-AG028050/AG/NIA NIH HHS/United States GR - N01-AG-6-2101/AG/NIA NIH HHS/United States GR - N01 AG062101/AG/NIA NIH HHS/United States GR - N01-AG-6-2103/AG/NIA NIH HHS/United States GR - R01 NR012459/NR/NINR NIH HHS/United States GR - K24 AG031155/AG/NIA NIH HHS/United States GR - N01-AG-6-2106/AG/NIA NIH HHS/United States GR - K24AG031155/AG/NIA NIH HHS/United States GR - R01-NR012459/NR/NINR NIH HHS/United States GR - R01 AG028050/AG/NIA NIH HHS/United States GR - ImNIH/Intramural NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, N.I.H., Intramural PT - Research Support, Non-U.S. Gov't DEP - 20140326 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Aged MH - Brain-Derived Neurotrophic Factor/*blood MH - Cognition Disorders/*blood MH - Confounding Factors, Epidemiologic MH - Cross-Sectional Studies MH - Female MH - Humans MH - Longitudinal Studies MH - Male PMC - PMC3966768 COIS- Competing Interests: The authors have read the journal's policy and have the following conflicts: Dr. Yaffe serves on data safety monitoring boards for Takeda, Inc., and a study sponsored by the NIH and has served as a consultant for Novartis, Inc. The other authors report no potential conflicts of interest. The conflict of interest does not alter the authors' adherence to PLOS ONE policies on sharing data and materials. FIR - Harris, Tamara B IR - Harris TB FIR - Garcia, Melissa E IR - Garcia ME FIR - Newman, Anne B IR - Newman AB FIR - Satterfield, Suzanne IR - Satterfield S FIR - Cummings, Steven R IR - Cummings SR FIR - Nevitt, Michael C IR - Nevitt MC FIR - Ives, Diane IR - Ives D FIR - Elam, Jan IR - Elam J FIR - Rubin, Susan M IR - Rubin SM EDAT- 2014/03/29 06:00 MHDA- 2015/12/15 06:00 PMCR- 2014/03/26 CRDT- 2014/03/28 06:00 PHST- 2013/12/02 00:00 [received] PHST- 2014/02/11 00:00 [accepted] PHST- 2014/03/28 06:00 [entrez] PHST- 2014/03/29 06:00 [pubmed] PHST- 2015/12/15 06:00 [medline] PHST- 2014/03/26 00:00 [pmc-release] AID - PONE-D-13-50782 [pii] AID - 10.1371/journal.pone.0091339 [doi] PST - epublish SO - PLoS One. 2014 Mar 26;9(3):e91339. doi: 10.1371/journal.pone.0091339. eCollection 2014.