PMID- 24672116
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140327
LR  - 20220331
IS  - 0011-393X (Print)
IS  - 0011-393X (Linking)
VI  - 66
IP  - 2
DP  - 2005 Mar
TI  - Antidepressant-related adverse effects impacting treatment compliance: Results of 
      a patient survey.
PG  - 96-106
LID - 10.1016/j.curtheres.2005.04.006 [doi]
AB  - BACKGROUND: Despite the high prevalence of depression in the United States, 10 
      few studies have identified which adverse effects (AEs) patients are willing or 
      unwilling to tolerate when receiving antidepressants. OBJECTIVE: The aim of this 
      study was to identify reasons for discontinuation10 and noncompliance with 
      antidepressant medications, the impact of AEs on compliance and quality of life 
      (assessed using impact of AEs on activities of daily living), and patients' 
      suggestions for improving their medication, using a patient survey. METHODS: 
      Patients aged 18 to 65 years with mild to severe depression were 10 randomly 
      selected by their physicians to be sent an invitation to complete the 42-question 
      survey. Three hundred physicians nationwide assessed the severity of depression 
      and symptoms of anxiety in each respondent, using their judgment. Patients were 
      asked specific questions to assess reasons for discontinuation/noncompliance. 
      Patients were also asked to rate AEs based on how difficult they were to "live 
      with," and what 2 aspects of their antidepressant medication they would change if 
      they could. RESULTS: In a separate, concurrent study, physicians classified 175 
      (50%) abdResults:0 mildly to moderately depressed and 84 (24%) as severely 
      depressed. Ninety-one respondents (26%) were classified as having symptoms of 
      anxiety. Two hundred seven patients (60%) indicated they had discontinued 
      treatment with an antidepressant agent at some point in their lives, the most 
      common reason for which was lack of efficacy (92 patients [44%]). Of the 344 
      patients currently being treated with an antidepressant, 75 (22%) reported 
      noncompliance. The most common reasons for noncompliance were "have trouble 
      remembering to take it" (19/44 patients [43%]), "gained a lot of weight" (11/41 
      [27%]), "unable to have an orgasm" (8/40 [20%]), and "lost interest in sex" (8/41 
      [20%]). The 4 AEs patients expressed as "extremely difficult to live with" were 
      "weight gain" (104 patients [31%]), "unable to have erection" (83 [25%]), 
      "difficulty reaching orgasm" (80 [24%]), and "tired during the day/no energy" (69 
      patients [21%]). The 3 most frequently cited improvements patients (n = 327) 
      would make to their medications were better efficacy (176 patients [54%]) and 
      eliminating AEs related to sexual desire and weight gain (112 [34%] and 105 [32%] 
      patients, respectively). CONCLUSIONS: The findings of this survey of patients 
      with mild to severe10 depression suggest that compliance, and hence efficacy, can 
      be promoted by (1) understanding what patients expect and desire from the 
      antidepressants they are prescribed and (2) prescribing antidepressants 
      associated with low rates of weight gain, sexual dysfunction, or tiredness.
FAU - Ashton, Adam Keller
AU  - Ashton AK
AD  - Department of Psychiatry, State University of New York at Buffalo, School of 
      Medicine and Biomedical Sciences, Williamsville, New York, USA.
FAU - Jamerson, Brenda D
AU  - Jamerson BD
AD  - Department of Clinical Research, Campbell University, Morrisville, North 
      Carolina, USA.
FAU - L Weinstein, Wendy
AU  - L Weinstein W
AD  - Department of Psychiatry, State University of New York at Buffalo, School of 
      Medicine and Biomedical Sciences, Williamsville, New York, USA.
FAU - Wagoner, Christine
AU  - Wagoner C
AD  - Department ofMarket Research, GlaxoSmithKline, Research Triangle Park, North 
      Carolina, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Curr Ther Res Clin Exp
JT  - Current therapeutic research, clinical and experimental
JID - 0372621
PMC - PMC3964563
OTO - NOTNLM
OT  - antidepressants
OT  - discontinuation
OT  - noncompliance
OT  - tolerability
EDAT- 2005/03/01 00:00
MHDA- 2005/03/01 00:01
PMCR- 2005/03/01
CRDT- 2014/03/28 06:00
PHST- 2005/02/09 00:00 [accepted]
PHST- 2014/03/28 06:00 [entrez]
PHST- 2005/03/01 00:00 [pubmed]
PHST- 2005/03/01 00:01 [medline]
PHST- 2005/03/01 00:00 [pmc-release]
AID - S0011-393X(05)00044-5 [pii]
AID - 10.1016/j.curtheres.2005.04.006 [doi]
PST - ppublish
SO  - Curr Ther Res Clin Exp. 2005 Mar;66(2):96-106. doi: 
      10.1016/j.curtheres.2005.04.006.