PMID- 24672150
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140327
LR  - 20240318
IS  - 0971-6203 (Print)
IS  - 1998-3913 (Electronic)
IS  - 0971-6203 (Linking)
VI  - 38
IP  - 4
DP  - 2013 Oct
TI  - Dosimetric comparison between IMRT delivery modes: Step-and-shoot, sliding 
      window, and volumetric modulated arc therapy - for whole pelvis radiation therapy 
      of intermediate-to-high risk prostate adenocarcinoma.
PG  - 165-72
LID - 10.4103/0971-6203.121193 [doi]
AB  - THIS STUDY WAS PERFORMED TO EVALUATE DOSIMETRIC DIFFERENCES BETWEEN CURRENT 
      INTENSITY MODULATED RADIATION THERAPY (IMRT) DELIVERY MODES: Step-and-shoot (SS), 
      sliding window (SW), and volumetric modulated arc therapy (VMAT). Plans for 15 
      prostate cancer patients with 10 MV photon beams using each IMRT mode were 
      generated. Patients had three planning target volumes (PTVs) including prostate, 
      prostate plus seminal vesicles, and pelvic lymphatics. Dose volume histograms 
      (DVHs) of PTVs and organs at risk (OARs), tumor control probability (TCP) and 
      normal tissue complication probabilities (NTCPs), conformation number, and 
      monitor units (MUs) used were compared. Statistical analysis was performed using 
      the analysis of variance (ANOVA) technique. The TCPs were < 99% with 
      insignificant differences among modalities (P > 0.99). Doses to all critical 
      structures were higher on average with SW method compared to SS, but 
      insignificant. NTCP values were lowest for VMAT in all structures excepting 
      bladder. Normal tissue volumes receiving doses in the 20-30 Gy range were reduced 
      for VMAT compared to SS. Percentage of MUs required for VMAT to deliver a 
      comparable plan to SS and SW was at least 40% less. In conclusion, similar target 
      coverage and normal tissue doses were found by the three compared modes and the 
      dosimetric differences were small.
FAU - Herman, Tania De La Fuente
AU  - Herman Tde L
AD  - Department of Radiation Oncology, Stephenson Cancer Center, University of 
      Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
FAU - Schnell, Erich
AU  - Schnell E
AD  - Department of Radiation Oncology, Stephenson Cancer Center, University of 
      Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
FAU - Young, Julie
AU  - Young J
AD  - Department of Radiation Oncology, Stephenson Cancer Center, University of 
      Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
FAU - Hildebrand, Kim
AU  - Hildebrand K
AD  - Department of Radiation Oncology, Stephenson Cancer Center, University of 
      Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
FAU - Algan, Ozer
AU  - Algan O
AD  - Department of Radiation Oncology, Stephenson Cancer Center, University of 
      Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
FAU - Syzek, Elizabeth
AU  - Syzek E
AD  - Department of Radiation Oncology, Stephenson Cancer Center, University of 
      Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
FAU - Herman, Terence
AU  - Herman T
AD  - Department of Radiation Oncology, Stephenson Cancer Center, University of 
      Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
FAU - Ahmad, Salahuddin
AU  - Ahmad S
AD  - Department of Radiation Oncology, Stephenson Cancer Center, University of 
      Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Med Phys
JT  - Journal of medical physics
JID - 9441104
PMC - PMC3958995
OTO - NOTNLM
OT  - Intensity modulated radiation therapy
OT  - prostate cancer
OT  - sliding window
OT  - step-and-shoot
OT  - volumetric modulated arc therapy
COIS- Conflict of Interest: None declared.
EDAT- 2014/03/29 06:00
MHDA- 2014/03/29 06:01
PMCR- 2013/10/01
CRDT- 2014/03/28 06:00
PHST- 2013/07/10 00:00 [received]
PHST- 2013/09/29 00:00 [revised]
PHST- 2013/10/02 00:00 [accepted]
PHST- 2014/03/28 06:00 [entrez]
PHST- 2014/03/29 06:00 [pubmed]
PHST- 2014/03/29 06:01 [medline]
PHST- 2013/10/01 00:00 [pmc-release]
AID - JMP-38-165 [pii]
AID - 10.4103/0971-6203.121193 [doi]
PST - ppublish
SO  - J Med Phys. 2013 Oct;38(4):165-72. doi: 10.4103/0971-6203.121193.