PMID- 24672701
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140327
LR  - 20211021
IS  - 2072-1439 (Print)
IS  - 2077-6624 (Electronic)
IS  - 2072-1439 (Linking)
VI  - 6 Suppl 1
IP  - Suppl 1
DP  - 2014 Mar
TI  - Effect of lornoxicam in lung inflammatory response syndrome after operations for 
      cardiac surgery with cardiopulmonary bypass.
PG  - S7-S20
LID - 10.3978/j.issn.2072-1439.2013.12.30 [doi]
AB  - BACKGROUND: The establishment of Extracorporeal Circulation (EC) significantly 
      contributed to improvement of cardiac surgery, but this is accompanied by harmful 
      side-effects. The most important of them is systemic inflammatory response 
      syndrome. Many efforts have been undertaken to minimize this problem but 
      unfortunately without satisfied solution to date. MATERIALS AND METHODS: 
      Lornoxicam is a non steroid anti-inflammatory drug which temporally inhibits the 
      cycloxygenase. In this clinical trial we study the effect of lornoxicam in lung 
      inflammatory response after operations for cardiac surgery with cardiopulmonary 
      bypass. In our study we conclude 14 volunteers patients with ischemic coronary 
      disease undergoing coronary artery bypass grafting with EC. In seven of them 16 
      mg lornoxicam was administered iv before the anesthesia induction and before the 
      connection in heart-lung machine. In control group (7 patients) we administered 
      the same amount of normal saline. RESULTS: Both groups are equal regarding 
      pro-operative and intra-operative parameters. The inflammatory markers were 
      calculated by Elisa method. We measured the levels of cytokines (IL-6, IL-8, 
      TNF-a), adhesion molecules (ICAM-1, e-Selectin, p-Selectin) and matrix 
      metaloproteinase-3 (MMP-3) just after anesthesia induction, before and after 
      cardiopulmonary bypass, just after the patients administration in ICU and after 8 
      and 24 hrs. In all patients we estimated the lung's inflammatory reaction with 
      lung biopsy taken at the begging and at the end of the operation. We calculated 
      hemodynamics parameters: Cardiac Index (CI), Systemic Vascular Resistance Index 
      (SVRI), Pulmonary Vascular Resistance Index (PVRI), Left Ventricular Stroke Work 
      Index (LVSWI), Right Ventricular Stroke Work Index (RVSWI), and the Pulmonary 
      arterial pressure, and respiratory parameters too: alveolo-arterial oxygen 
      difference D (A-a), intrapulmonary shunt (Qs/Qt) and pulmonary Compliance. IL-6 
      levels of lornoxicam group were statistical significant lower at 1st 
      postoperative day compared to them of control group (113+/-49 and 177+/-20 
      respectively, P=0.008). ICAM-1 levels were statistical significant lower at the 
      patient admission in ICU, compared to them of control group (177+/-29 and 217+/-22 
      respectively, P=0.014), and the 1st postoperative day compared to them in control 
      group (281+/-134 and 489+/-206 respectively, P=0.045). P-selectin levels were 
      statistical significant lower, compared to them in control group in four 
      measurements (97+/-23 and 119+/-7 respectively, P=0.030, 77+/-19 and 101+/-20 
      respectively, P=0.044, 86+/-4 and 105+/-13 respectively, P=0.06, 116+/-13 and 158+/-17 
      respectively, P=0.000). CONCLUSIONS: Hemodynamics and respiratory parameters were 
      improved compared to control group, but these differences was not statistical 
      significant. Eosinofil adhesion and sequestration in intermediate tissue of lung 
      parenchyma were significantly lower compared to control group. Also, alveolar 
      edema was not noted in lornoxicam's group. Lornoxicam reduce the inflammatory 
      response in patients undergone coronary artery bypass grafting with 
      extracorporeal circulation. This calculated from levels reduction of IL-6, ICAM-1 
      kappaalphaiota p-Selectin, and from lung pathologoanatomic examination (absence of alveolar 
      edema, reduce in eosinofil adhesion and sequestration in intermediate tissues). 
      Despite the favorable effect of lornoxicam on the hemodinamics and respiratory 
      parameters these improvement did not seem to be statistical significant.
FAU - Tsakiridis, Kosmas
AU  - Tsakiridis K
AD  - 1 Cardiothoracic Surgery Department, "Saint Luke" Private Hospital, Thessaloniki, 
      Panorama, Greece ; 2 Pulmonary Department-Oncology Unit, G Papanikolaou General 
      Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 
      Anesthisiology Department, University of Larisa, Larisa, Greece ; 4 
      Cardiothoracic Surgery Department, University General Hospital of 
      Alexandroupolis, Alexandroupolis, Greece ; 5 Oncology Department, 6 Anesthisology 
      Department, 7 Cardiology Department, "Saint Luke" Private Hospital, Thessaloniki, 
      Panorama, Greece ; 8 Surgery Department (NHS), University General Hospital of 
      Alexandroupolis, Alexandroupolis, Greece ; 9 Internal Medicine Department, 
      "Thegeneio" Cancer Hospital, Thessaloniki, Greece ; 10 Cardiothoracic Surgery 
      Department, University of Ioannina, Ioannina, Greece.
FAU - Zarogoulidis, Paul
AU  - Zarogoulidis P
AD  - 1 Cardiothoracic Surgery Department, "Saint Luke" Private Hospital, Thessaloniki, 
      Panorama, Greece ; 2 Pulmonary Department-Oncology Unit, G Papanikolaou General 
      Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 
      Anesthisiology Department, University of Larisa, Larisa, Greece ; 4 
      Cardiothoracic Surgery Department, University General Hospital of 
      Alexandroupolis, Alexandroupolis, Greece ; 5 Oncology Department, 6 Anesthisology 
      Department, 7 Cardiology Department, "Saint Luke" Private Hospital, Thessaloniki, 
      Panorama, Greece ; 8 Surgery Department (NHS), University General Hospital of 
      Alexandroupolis, Alexandroupolis, Greece ; 9 Internal Medicine Department, 
      "Thegeneio" Cancer Hospital, Thessaloniki, Greece ; 10 Cardiothoracic Surgery 
      Department, University of Ioannina, Ioannina, Greece.
FAU - Vretzkakis, Giorgos
AU  - Vretzkakis G
AD  - 1 Cardiothoracic Surgery Department, "Saint Luke" Private Hospital, Thessaloniki, 
      Panorama, Greece ; 2 Pulmonary Department-Oncology Unit, G Papanikolaou General 
      Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 
      Anesthisiology Department, University of Larisa, Larisa, Greece ; 4 
      Cardiothoracic Surgery Department, University General Hospital of 
      Alexandroupolis, Alexandroupolis, Greece ; 5 Oncology Department, 6 Anesthisology 
      Department, 7 Cardiology Department, "Saint Luke" Private Hospital, Thessaloniki, 
      Panorama, Greece ; 8 Surgery Department (NHS), University General Hospital of 
      Alexandroupolis, Alexandroupolis, Greece ; 9 Internal Medicine Department, 
      "Thegeneio" Cancer Hospital, Thessaloniki, Greece ; 10 Cardiothoracic Surgery 
      Department, University of Ioannina, Ioannina, Greece.
FAU - Mikroulis, Dimitris
AU  - Mikroulis D
AD  - 1 Cardiothoracic Surgery Department, "Saint Luke" Private Hospital, Thessaloniki, 
      Panorama, Greece ; 2 Pulmonary Department-Oncology Unit, G Papanikolaou General 
      Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 
      Anesthisiology Department, University of Larisa, Larisa, Greece ; 4 
      Cardiothoracic Surgery Department, University General Hospital of 
      Alexandroupolis, Alexandroupolis, Greece ; 5 Oncology Department, 6 Anesthisology 
      Department, 7 Cardiology Department, "Saint Luke" Private Hospital, Thessaloniki, 
      Panorama, Greece ; 8 Surgery Department (NHS), University General Hospital of 
      Alexandroupolis, Alexandroupolis, Greece ; 9 Internal Medicine Department, 
      "Thegeneio" Cancer Hospital, Thessaloniki, Greece ; 10 Cardiothoracic Surgery 
      Department, University of Ioannina, Ioannina, Greece.
FAU - Mpakas, Andreas
AU  - Mpakas A
AD  - 1 Cardiothoracic Surgery Department, "Saint Luke" Private Hospital, Thessaloniki, 
      Panorama, Greece ; 2 Pulmonary Department-Oncology Unit, G Papanikolaou General 
      Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 
      Anesthisiology Department, University of Larisa, Larisa, Greece ; 4 
      Cardiothoracic Surgery Department, University General Hospital of 
      Alexandroupolis, Alexandroupolis, Greece ; 5 Oncology Department, 6 Anesthisology 
      Department, 7 Cardiology Department, "Saint Luke" Private Hospital, Thessaloniki, 
      Panorama, Greece ; 8 Surgery Department (NHS), University General Hospital of 
      Alexandroupolis, Alexandroupolis, Greece ; 9 Internal Medicine Department, 
      "Thegeneio" Cancer Hospital, Thessaloniki, Greece ; 10 Cardiothoracic Surgery 
      Department, University of Ioannina, Ioannina, Greece.
FAU - Kesisis, Georgios
AU  - Kesisis G
AD  - 1 Cardiothoracic Surgery Department, "Saint Luke" Private Hospital, Thessaloniki, 
      Panorama, Greece ; 2 Pulmonary Department-Oncology Unit, G Papanikolaou General 
      Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 
      Anesthisiology Department, University of Larisa, Larisa, Greece ; 4 
      Cardiothoracic Surgery Department, University General Hospital of 
      Alexandroupolis, Alexandroupolis, Greece ; 5 Oncology Department, 6 Anesthisology 
      Department, 7 Cardiology Department, "Saint Luke" Private Hospital, Thessaloniki, 
      Panorama, Greece ; 8 Surgery Department (NHS), University General Hospital of 
      Alexandroupolis, Alexandroupolis, Greece ; 9 Internal Medicine Department, 
      "Thegeneio" Cancer Hospital, Thessaloniki, Greece ; 10 Cardiothoracic Surgery 
      Department, University of Ioannina, Ioannina, Greece.
FAU - Arikas, Stamatis
AU  - Arikas S
AD  - 1 Cardiothoracic Surgery Department, "Saint Luke" Private Hospital, Thessaloniki, 
      Panorama, Greece ; 2 Pulmonary Department-Oncology Unit, G Papanikolaou General 
      Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 
      Anesthisiology Department, University of Larisa, Larisa, Greece ; 4 
      Cardiothoracic Surgery Department, University General Hospital of 
      Alexandroupolis, Alexandroupolis, Greece ; 5 Oncology Department, 6 Anesthisology 
      Department, 7 Cardiology Department, "Saint Luke" Private Hospital, Thessaloniki, 
      Panorama, Greece ; 8 Surgery Department (NHS), University General Hospital of 
      Alexandroupolis, Alexandroupolis, Greece ; 9 Internal Medicine Department, 
      "Thegeneio" Cancer Hospital, Thessaloniki, Greece ; 10 Cardiothoracic Surgery 
      Department, University of Ioannina, Ioannina, Greece.
FAU - Kolettas, Alexandros
AU  - Kolettas A
AD  - 1 Cardiothoracic Surgery Department, "Saint Luke" Private Hospital, Thessaloniki, 
      Panorama, Greece ; 2 Pulmonary Department-Oncology Unit, G Papanikolaou General 
      Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 
      Anesthisiology Department, University of Larisa, Larisa, Greece ; 4 
      Cardiothoracic Surgery Department, University General Hospital of 
      Alexandroupolis, Alexandroupolis, Greece ; 5 Oncology Department, 6 Anesthisology 
      Department, 7 Cardiology Department, "Saint Luke" Private Hospital, Thessaloniki, 
      Panorama, Greece ; 8 Surgery Department (NHS), University General Hospital of 
      Alexandroupolis, Alexandroupolis, Greece ; 9 Internal Medicine Department, 
      "Thegeneio" Cancer Hospital, Thessaloniki, Greece ; 10 Cardiothoracic Surgery 
      Department, University of Ioannina, Ioannina, Greece.
FAU - Moschos, Giorgios
AU  - Moschos G
AD  - 1 Cardiothoracic Surgery Department, "Saint Luke" Private Hospital, Thessaloniki, 
      Panorama, Greece ; 2 Pulmonary Department-Oncology Unit, G Papanikolaou General 
      Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 
      Anesthisiology Department, University of Larisa, Larisa, Greece ; 4 
      Cardiothoracic Surgery Department, University General Hospital of 
      Alexandroupolis, Alexandroupolis, Greece ; 5 Oncology Department, 6 Anesthisology 
      Department, 7 Cardiology Department, "Saint Luke" Private Hospital, Thessaloniki, 
      Panorama, Greece ; 8 Surgery Department (NHS), University General Hospital of 
      Alexandroupolis, Alexandroupolis, Greece ; 9 Internal Medicine Department, 
      "Thegeneio" Cancer Hospital, Thessaloniki, Greece ; 10 Cardiothoracic Surgery 
      Department, University of Ioannina, Ioannina, Greece.
FAU - Katsikogiannis, Nikolaos
AU  - Katsikogiannis N
AD  - 1 Cardiothoracic Surgery Department, "Saint Luke" Private Hospital, Thessaloniki, 
      Panorama, Greece ; 2 Pulmonary Department-Oncology Unit, G Papanikolaou General 
      Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 
      Anesthisiology Department, University of Larisa, Larisa, Greece ; 4 
      Cardiothoracic Surgery Department, University General Hospital of 
      Alexandroupolis, Alexandroupolis, Greece ; 5 Oncology Department, 6 Anesthisology 
      Department, 7 Cardiology Department, "Saint Luke" Private Hospital, Thessaloniki, 
      Panorama, Greece ; 8 Surgery Department (NHS), University General Hospital of 
      Alexandroupolis, Alexandroupolis, Greece ; 9 Internal Medicine Department, 
      "Thegeneio" Cancer Hospital, Thessaloniki, Greece ; 10 Cardiothoracic Surgery 
      Department, University of Ioannina, Ioannina, Greece.
FAU - Machairiotis, Nikolaos
AU  - Machairiotis N
AD  - 1 Cardiothoracic Surgery Department, "Saint Luke" Private Hospital, Thessaloniki, 
      Panorama, Greece ; 2 Pulmonary Department-Oncology Unit, G Papanikolaou General 
      Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 
      Anesthisiology Department, University of Larisa, Larisa, Greece ; 4 
      Cardiothoracic Surgery Department, University General Hospital of 
      Alexandroupolis, Alexandroupolis, Greece ; 5 Oncology Department, 6 Anesthisology 
      Department, 7 Cardiology Department, "Saint Luke" Private Hospital, Thessaloniki, 
      Panorama, Greece ; 8 Surgery Department (NHS), University General Hospital of 
      Alexandroupolis, Alexandroupolis, Greece ; 9 Internal Medicine Department, 
      "Thegeneio" Cancer Hospital, Thessaloniki, Greece ; 10 Cardiothoracic Surgery 
      Department, University of Ioannina, Ioannina, Greece.
FAU - Tsiouda, Theodora
AU  - Tsiouda T
AD  - 1 Cardiothoracic Surgery Department, "Saint Luke" Private Hospital, Thessaloniki, 
      Panorama, Greece ; 2 Pulmonary Department-Oncology Unit, G Papanikolaou General 
      Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 
      Anesthisiology Department, University of Larisa, Larisa, Greece ; 4 
      Cardiothoracic Surgery Department, University General Hospital of 
      Alexandroupolis, Alexandroupolis, Greece ; 5 Oncology Department, 6 Anesthisology 
      Department, 7 Cardiology Department, "Saint Luke" Private Hospital, Thessaloniki, 
      Panorama, Greece ; 8 Surgery Department (NHS), University General Hospital of 
      Alexandroupolis, Alexandroupolis, Greece ; 9 Internal Medicine Department, 
      "Thegeneio" Cancer Hospital, Thessaloniki, Greece ; 10 Cardiothoracic Surgery 
      Department, University of Ioannina, Ioannina, Greece.
FAU - Siminelakis, Stavros
AU  - Siminelakis S
AD  - 1 Cardiothoracic Surgery Department, "Saint Luke" Private Hospital, Thessaloniki, 
      Panorama, Greece ; 2 Pulmonary Department-Oncology Unit, G Papanikolaou General 
      Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 
      Anesthisiology Department, University of Larisa, Larisa, Greece ; 4 
      Cardiothoracic Surgery Department, University General Hospital of 
      Alexandroupolis, Alexandroupolis, Greece ; 5 Oncology Department, 6 Anesthisology 
      Department, 7 Cardiology Department, "Saint Luke" Private Hospital, Thessaloniki, 
      Panorama, Greece ; 8 Surgery Department (NHS), University General Hospital of 
      Alexandroupolis, Alexandroupolis, Greece ; 9 Internal Medicine Department, 
      "Thegeneio" Cancer Hospital, Thessaloniki, Greece ; 10 Cardiothoracic Surgery 
      Department, University of Ioannina, Ioannina, Greece.
FAU - Beleveslis, Thomas
AU  - Beleveslis T
AD  - 1 Cardiothoracic Surgery Department, "Saint Luke" Private Hospital, Thessaloniki, 
      Panorama, Greece ; 2 Pulmonary Department-Oncology Unit, G Papanikolaou General 
      Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 
      Anesthisiology Department, University of Larisa, Larisa, Greece ; 4 
      Cardiothoracic Surgery Department, University General Hospital of 
      Alexandroupolis, Alexandroupolis, Greece ; 5 Oncology Department, 6 Anesthisology 
      Department, 7 Cardiology Department, "Saint Luke" Private Hospital, Thessaloniki, 
      Panorama, Greece ; 8 Surgery Department (NHS), University General Hospital of 
      Alexandroupolis, Alexandroupolis, Greece ; 9 Internal Medicine Department, 
      "Thegeneio" Cancer Hospital, Thessaloniki, Greece ; 10 Cardiothoracic Surgery 
      Department, University of Ioannina, Ioannina, Greece.
FAU - Zarogoulidis, Konstantinos
AU  - Zarogoulidis K
AD  - 1 Cardiothoracic Surgery Department, "Saint Luke" Private Hospital, Thessaloniki, 
      Panorama, Greece ; 2 Pulmonary Department-Oncology Unit, G Papanikolaou General 
      Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 
      Anesthisiology Department, University of Larisa, Larisa, Greece ; 4 
      Cardiothoracic Surgery Department, University General Hospital of 
      Alexandroupolis, Alexandroupolis, Greece ; 5 Oncology Department, 6 Anesthisology 
      Department, 7 Cardiology Department, "Saint Luke" Private Hospital, Thessaloniki, 
      Panorama, Greece ; 8 Surgery Department (NHS), University General Hospital of 
      Alexandroupolis, Alexandroupolis, Greece ; 9 Internal Medicine Department, 
      "Thegeneio" Cancer Hospital, Thessaloniki, Greece ; 10 Cardiothoracic Surgery 
      Department, University of Ioannina, Ioannina, Greece.
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Thorac Dis
JT  - Journal of thoracic disease
JID - 101533916
PMC - PMC3966149
OTO - NOTNLM
OT  - Lornoxicam
OT  - cardiac surgery
OT  - cardiopulmonary bypass
OT  - extracorporeal circulation
OT  - left ventricular stroke work index (LVSWI)
OT  - pulmonary vascular resistance index (PVRI)
OT  - right ventricular stroke work index (RVSWI)
OT  - systemic vascular resistance index (SVRI)
EDAT- 2014/03/29 06:00
MHDA- 2014/03/29 06:01
PMCR- 2014/03/01
CRDT- 2014/03/28 06:00
PHST- 2013/12/09 00:00 [received]
PHST- 2013/12/16 00:00 [accepted]
PHST- 2014/03/28 06:00 [entrez]
PHST- 2014/03/29 06:00 [pubmed]
PHST- 2014/03/29 06:01 [medline]
PHST- 2014/03/01 00:00 [pmc-release]
AID - jtd-06-S1-S7 [pii]
AID - 10.3978/j.issn.2072-1439.2013.12.30 [doi]
PST - ppublish
SO  - J Thorac Dis. 2014 Mar;6 Suppl 1(Suppl 1):S7-S20. doi: 
      10.3978/j.issn.2072-1439.2013.12.30.