PMID- 24672722
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140327
LR  - 20220330
IS  - 2090-1925 (Print)
IS  - 2090-1933 (Electronic)
IS  - 2090-1933 (Linking)
VI  - 2014
DP  - 2014
TI  - The Relationship of HLA Class I and II Alleles and Haplotypes with Autism: A Case 
      Control Study.
PG  - 242048
LID - 10.1155/2014/242048 [doi]
LID - 242048
AB  - Earlier reports showed the relationship between autism and immune genes located 
      in the human leukocyte antigen (HLA). In this current study, we compared the HLA 
      class I and class II alleles and haplotypes in 35 autistic children with 100 
      control subjects from Saudi Arabia, using PCR-SSP method and Luminex technology. 
      In class I the HLA-A*01 (P = 0.03, OR 2.68), A*02 (P = 0.001, OR 3.02) and 
      HLA-B*07 (P = 0.01, OR 3.27), were significantly associated with autism. Also, 
      the haplotype A*02-B*07 was significantly higher in autistic patients than in 
      controls (P = 0.007, OR 5.83). In class II, DRB1*1104 was significantly higher in 
      patients than in controls (P = 0.001, OR 8.75). The DQB1*0202 (P = 0.001, OR 
      0.24), DQB1*0302 (P = 0.001, OR 0.14), and DQB1*0501 (P = 0.012, OR 0.25), were 
      negatively associated with disease. While the four-loci genotype study showed 
      that A*01-B*07-DRB1*0701-DQB1*0602 (P = 0.001, OR 41.9) and the 
      A*31-B*51-DRB1*0103-DQB1*0302 (P = 0.012, OR 4.8) are positively associated with 
      autism among Saudi patients. This is the first report on a foreseeable risk of 
      association of HLA-B*07 allele with autism. Thus, HLA-B*07 allele and the closely 
      linked haplotype A*01 B*07 DRB1*0701 DQB1*0602 may serve as a marker for genetic 
      susceptibility to autism in Saudis.
FAU - Al-Hakbany, Manan
AU  - Al-Hakbany M
AD  - College of Medicine, King Saud University, P.O. Box 2925, Riyadh 11461, Saudi 
      Arabia.
FAU - Awadallah, Sitalbanat
AU  - Awadallah S
AD  - College of Medicine, King Saud University, P.O. Box 2925, Riyadh 11461, Saudi 
      Arabia.
FAU - Al-Ayadhi, Laila
AU  - Al-Ayadhi L
AUID- ORCID: 0000-0003-3269-0416
AD  - College of Medicine, King Saud University, P.O. Box 2925, Riyadh 11461, Saudi 
      Arabia ; Autism Research and Treatment Center, Al-Amodi Autism Research Chair, 
      Saudi Arabia.
LA  - eng
PT  - Journal Article
DEP - 20140203
PL  - Egypt
TA  - Autism Res Treat
JT  - Autism research and treatment
JID - 101576459
PMC - PMC3929985
EDAT- 2014/03/29 06:00
MHDA- 2014/03/29 06:01
PMCR- 2014/02/03
CRDT- 2014/03/28 06:00
PHST- 2013/08/12 00:00 [received]
PHST- 2013/11/30 00:00 [revised]
PHST- 2013/12/02 00:00 [accepted]
PHST- 2014/03/28 06:00 [entrez]
PHST- 2014/03/29 06:00 [pubmed]
PHST- 2014/03/29 06:01 [medline]
PHST- 2014/02/03 00:00 [pmc-release]
AID - 10.1155/2014/242048 [doi]
PST - ppublish
SO  - Autism Res Treat. 2014;2014:242048. doi: 10.1155/2014/242048. Epub 2014 Feb 3.