PMID- 24674399
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140331
LR  - 20160519
IS  - 1879-8519 (Electronic)
IS  - 1879-8500 (Linking)
VI  - 3
IP  - 4
DP  - 2013 Oct-Dec
TI  - Dosimetric feasibility of sparing the primary site for oropharyngeal squamous 
      cell carcinoma after transoral laser microsurgery in patients with unilateral 
      positive neck nodes.
PG  - 282-6
LID - S1879-8500(12)00192-0 [pii]
LID - 10.1016/j.prro.2012.10.001 [doi]
AB  - PURPOSE: To quantify the effect of sparing the primary site after transoral laser 
      microsurgery (TLM) for oropharyngeal squamous cell carcinoma (OPSCC). METHODS AND 
      MATERIALS: We reviewed 4 patients with OPSCC who were treated with TLM and 
      postoperative radiation. All patients had T1 base of tongue primaries with the 
      following N stages: 1 N1; 2 N2a; and 1 N2b. Three were lateralized to the right 
      and 1 lateralized to the left. The primary site was not spared initially. We 
      created new intensity modulated radiation treatment (IMRT) plans that spared the 
      primary site. The prescribed dose to the high-risk (HR) and standard-risk (SR) 
      planning target volumes (PTVs) was 60 Gy and 46 Gy at 2 Gy/fraction. PTV-SR and 
      PTV-HR were adjusted to exclude the primary site. The primary site was maximally 
      spared while maintaining similar PTV coverage and normal tissue avoidance as the 
      initial plan. Dosimetric comparisons were made between the initial and 
      primary-site sparing IMRT plans. RESULTS: Dosimetric coverage of the PTVs and 
      normal tissues (pharyngeal constrictors, contralateral parotid, etc) were 
      comparable. The mean dose to the primary site was reduced by 20 Gy. The mean dose 
      to the oral cavity was reduced by 25 Gy. CONCLUSIONS: This study suggests that 
      omitting the primary site from the radiation therapy target volume is unlikely to 
      reduce long-term swallowing function to a meaningful degree in patients who 
      receive radiation therapy following TLM for base of tongue cancer.
CI  - Copyright (c) 2013 American Society for Radiation Oncology. Published by Elsevier 
      Inc. All rights reserved.
FAU - Fried, David
AU  - Fried D
AD  - Department of Radiation Oncology, University of North Carolina-Chapel Hill, 
      Chapel Hill, North Carolina.
FAU - Lehman-Davis, Misty
AU  - Lehman-Davis M
AD  - Department of Radiation Oncology, University of North Carolina-Chapel Hill, 
      Chapel Hill, North Carolina.
FAU - Willson, Adam
AU  - Willson A
AD  - Department of Radiation Oncology, University of North Carolina-Chapel Hill, 
      Chapel Hill, North Carolina.
FAU - Kostich, Mark
AU  - Kostich M
AD  - Department of Radiation Oncology, University of North Carolina-Chapel Hill, 
      Chapel Hill, North Carolina.
FAU - Hackman, Trevor
AU  - Hackman T
AD  - Department of Otolaryngology, University of North Carolina-Chapel Hill, Chapel 
      Hill, North Carolina; Lineberger Comprehensive Cancer Center, University of North 
      Carolina-Chapel Hill, University of North Carolina-Chapel Hill, Chapel Hill, 
      North Carolina.
FAU - Lian, Jun
AU  - Lian J
AD  - Department of Radiation Oncology, University of North Carolina-Chapel Hill, 
      Chapel Hill, North Carolina.
FAU - Burkhardt, Kathy
AU  - Burkhardt K
AD  - Department of Radiation Oncology, University of North Carolina-Chapel Hill, 
      Chapel Hill, North Carolina.
FAU - Chera, Bhishamjit
AU  - Chera B
AD  - Department of Radiation Oncology, University of North Carolina-Chapel Hill, 
      Chapel Hill, North Carolina; Lineberger Comprehensive Cancer Center, University 
      of North Carolina-Chapel Hill, University of North Carolina-Chapel Hill, Chapel 
      Hill, North Carolina. Electronic address: bchera@med.unc.edu.
LA  - eng
PT  - Journal Article
DEP - 20121102
PL  - United States
TA  - Pract Radiat Oncol
JT  - Practical radiation oncology
JID - 101558279
EDAT- 2014/03/29 06:00
MHDA- 2014/03/29 06:01
CRDT- 2014/03/29 06:00
PHST- 2012/07/20 00:00 [received]
PHST- 2012/09/28 00:00 [revised]
PHST- 2012/10/01 00:00 [accepted]
PHST- 2014/03/29 06:00 [entrez]
PHST- 2014/03/29 06:00 [pubmed]
PHST- 2014/03/29 06:01 [medline]
AID - S1879-8500(12)00192-0 [pii]
AID - 10.1016/j.prro.2012.10.001 [doi]
PST - ppublish
SO  - Pract Radiat Oncol. 2013 Oct-Dec;3(4):282-6. doi: 10.1016/j.prro.2012.10.001. 
      Epub 2012 Nov 2.