PMID- 24674728
OWN - NLM
STAT- MEDLINE
DCOM- 20150411
LR  - 20140328
IS  - 0578-1426 (Print)
IS  - 0578-1426 (Linking)
VI  - 53
IP  - 1
DP  - 2014 Jan
TI  - [A clinical analysis of ocular involvement in 111 cases of Behcet's disease].
PG  - 44-7
AB  - OBJECTIVE: To study the ocular manifestations in patients with Behcet's 
      disease(BD). METHODS: Medical records at Peking Union Medical College Hospital 
      from 2002 to 2012 were reviewed to identify the patients who were diagnosed as BD 
      with ocular involvement. RESULTS: One hundred and eleven BD patients developed 
      ocular involvement. Males were more frequently involved, and the male/ female 
      ratio was 2.08: 1. The age at the onset of BD and the time of ocular involvement 
      were (27.6 +/- 10.8) and (31.5 +/- 10.7) years, respectively. The median interval 
      between the diagnosis of BD and ocular disease was 24 (0, 372) months. Ocular 
      involvement was bilateral in 85.6% patients. About two thirds patients (66.7%) 
      had impaired vision, for example, visual acuity of 0.1 or less was detected in 
      60.4% patients. Uveitis (90.1%) was the most common findings in BD patients with 
      ocular involvement and the most frequent type of uveitis in both sexes was 
      panuveitis (62.16%). Vision loss, proliferative retinopathy and cataract were 
      more common in men. There was a statistically significantly higher frequency of 
      positive human leukocyte antigen(HLA)-B51 in the male BD with ocular involvement 
      than in the female. All BD patients with uveitis were given systemic 
      corticosteroid or combined immunosuppressive agents. The improvement of visual 
      acuity was seen in 77% BD patients, but the recurrent attacks occurred in 49% 
      patients, resulting in blindness in 25.5% of them. TNFalpha blockers were given to 19 
      recurrent uveitis patients, 12 patients improved while two had no response. 
      CONCLUSIONS: The most common ocular involvement in BD was uveitis. Males were 
      more frequently involved with a more severe disease, higher complications and 
      positive HLA-B51 than in females. Glucocorticoids and immunosuppressants were 
      effective to uveitis, but high rate of recurrent inflammatory ocular attacks led 
      to high risk of blindness. TNFalpha blockers may improve the outcome of recurrent BD 
      uveitis.
FAU - Wu, Honghua
AU  - Wu H
FAU - Li, Guohua
AU  - Li G
FAU - Chen, Hua
AU  - Chen H
FAU - Zheng, Wenjie
AU  - Zheng W
AD  - Department of Rheumatology, Peking Union Medical College Hospital, Peking Union 
      Medical College, Chinese Academy of Medical Sciences, Beijing 100032, China. 
      Email: zhengwj@pumch.cn.
FAU - Zhang, Meifen
AU  - Zhang M
FAU - Zhao, Yan
AU  - Zhao Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Nei Ke Za Zhi
JT  - Zhonghua nei ke za zhi
JID - 16210490R
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Behcet Syndrome
MH  - Female
MH  - Humans
MH  - Male
MH  - Retrospective Studies
MH  - *Uveitis
MH  - Young Adult
EDAT- 2014/03/29 06:00
MHDA- 2015/04/12 06:00
CRDT- 2014/03/29 06:00
PHST- 2014/03/29 06:00 [entrez]
PHST- 2014/03/29 06:00 [pubmed]
PHST- 2015/04/12 06:00 [medline]
PST - ppublish
SO  - Zhonghua Nei Ke Za Zhi. 2014 Jan;53(1):44-7.