PMID- 24674929
OWN - NLM
STAT- MEDLINE
DCOM- 20150715
LR  - 20180816
IS  - 1873-7528 (Electronic)
IS  - 0149-7634 (Linking)
VI  - 42
DP  - 2014 May
TI  - The association of the BDNF Val66Met polymorphism and the hippocampal volumes in 
      healthy humans: a joint meta-analysis of published and new data.
PG  - 267-78
LID - S0149-7634(14)00065-7 [pii]
LID - 10.1016/j.neubiorev.2014.03.011 [doi]
AB  - BACKGROUND: The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism 
      (refSNP Cluster Report: rs6265) is a common and functionally relevant single 
      nucleotide polymorphism (SNP). The gene itself, as well as the SNP rs6265, have 
      been implicated in hippocampal learning and memory. However, imaging genetic 
      studies have produced controversial results about the impact of this SNP on 
      hippocampal volumes in healthy subjects. METHODS: We examined the association 
      between the rs6265 polymorphism and hippocampal volume in 643 healthy young 
      subjects using automatic segmentation and subsequently included these data in a 
      meta-analysis based on published studies with 5298 healthy subjects in total. 
      RESULTS: We found no significant association between SNP rs6265 and hippocampal 
      volumes in our sample (g=0.05, p=0.58). The meta-analysis revealed a small, 
      albeit significant difference in hippocampal volumes between genotype groups, 
      such that Met-carriers had slightly smaller hippocampal volumes than Val/Val 
      homozygotes (g=0.09, p=0.04), an association that was only evident when manual 
      (g=0.22, p=0.01) but not automatic tracing approaches (g=0.04, p=0.38) were used. 
      Studies using manual tracing showed evidence for publication bias and a 
      significant decrease in effect size over the years with increasing sample sizes. 
      CONCLUSIONS: This study does not support the association between SNP rs6265 and 
      hippocampal volume in healthy individuals. The weakly significant effect observed 
      in the meta-analysis is mainly driven by studies with small sample sizes. In 
      contrast, our original data and the meta-analysis of automatically segmented 
      hippocampal volumes, which was based on studies with large samples sizes, 
      revealed no significant genotype effect. Thus, meta-analyses of the association 
      between rs6265 and hippocampal volumes should consider possible biases related to 
      measuring technique and sample size.
CI  - Copyright (c) 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Harrisberger, F
AU  - Harrisberger F
AD  - University of Basel, Department of Psychiatry (UPK), Wilhelm Klein-Strasse 27, 
      4056 Basel, Switzerland; University Hospital Basel, Medical Image Analysis 
      Center, Schanzenstrasse 55, 4031 Basel, Switzerland.
FAU - Spalek, K
AU  - Spalek K
AD  - University of Basel, Department of Psychology, Division of Cognitive 
      Neuroscience, Birmannsgasse 8, 4055 Basel, Switzerland.
FAU - Smieskova, R
AU  - Smieskova R
AD  - University of Basel, Department of Psychiatry (UPK), Wilhelm Klein-Strasse 27, 
      4056 Basel, Switzerland; University Hospital Basel, Medical Image Analysis 
      Center, Schanzenstrasse 55, 4031 Basel, Switzerland.
FAU - Schmidt, A
AU  - Schmidt A
AD  - University of Basel, Department of Psychiatry (UPK), Wilhelm Klein-Strasse 27, 
      4056 Basel, Switzerland; University Hospital Basel, Medical Image Analysis 
      Center, Schanzenstrasse 55, 4031 Basel, Switzerland.
FAU - Coynel, D
AU  - Coynel D
AD  - University of Basel, Department of Psychology, Division of Cognitive 
      Neuroscience, Birmannsgasse 8, 4055 Basel, Switzerland; University of Basel, 
      Department of Psychology, Division of Molecular Neuroscience, Birmannsgasse 8, 
      4055 Basel, Switzerland.
FAU - Milnik, A
AU  - Milnik A
AD  - University of Basel, Department of Psychology, Division of Molecular 
      Neuroscience, Birmannsgasse 8, 4055 Basel, Switzerland.
FAU - Fastenrath, M
AU  - Fastenrath M
AD  - University of Basel, Department of Psychology, Division of Cognitive 
      Neuroscience, Birmannsgasse 8, 4055 Basel, Switzerland.
FAU - Freytag, V
AU  - Freytag V
AD  - University of Basel, Department of Psychology, Division of Molecular 
      Neuroscience, Birmannsgasse 8, 4055 Basel, Switzerland.
FAU - Gschwind, L
AU  - Gschwind L
AD  - University of Basel, Department of Psychology, Division of Cognitive 
      Neuroscience, Birmannsgasse 8, 4055 Basel, Switzerland.
FAU - Walter, A
AU  - Walter A
AD  - University of Basel, Department of Psychiatry (UPK), Wilhelm Klein-Strasse 27, 
      4056 Basel, Switzerland.
FAU - Vogel, T
AU  - Vogel T
AD  - University of Basel, Department of Psychiatry (UPK), Wilhelm Klein-Strasse 27, 
      4056 Basel, Switzerland.
FAU - Bendfeldt, K
AU  - Bendfeldt K
AD  - University Hospital Basel, Medical Image Analysis Center, Schanzenstrasse 55, 
      4031 Basel, Switzerland.
FAU - de Quervain, D J-F
AU  - de Quervain DJ
AD  - University of Basel, Department of Psychiatry (UPK), Wilhelm Klein-Strasse 27, 
      4056 Basel, Switzerland; University of Basel, Department of Psychology, Division 
      of Cognitive Neuroscience, Birmannsgasse 8, 4055 Basel, Switzerland.
FAU - Papassotiropoulos, A
AU  - Papassotiropoulos A
AD  - University of Basel, Department of Psychiatry (UPK), Wilhelm Klein-Strasse 27, 
      4056 Basel, Switzerland; University of Basel, Department of Psychology, Division 
      of Molecular Neuroscience, Birmannsgasse 8, 4055 Basel, Switzerland; University 
      of Basel, Department Biozentrum, Life Science Training Facility, 
      Klingelbergstrasse 50/70, 4056 Basel, Switzerland.
FAU - Borgwardt, S
AU  - Borgwardt S
AD  - University of Basel, Department of Psychiatry (UPK), Wilhelm Klein-Strasse 27, 
      4056 Basel, Switzerland; University Hospital Basel, Medical Image Analysis 
      Center, Schanzenstrasse 55, 4031 Basel, Switzerland; King's College London, 
      Department of Psychosis Studies, Institute of Psychiatry, De Crespigny Park 16, 
      SE5 8AF London, UK. Electronic address: stefan.borgwardt@upkbs.ch.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20140324
PL  - United States
TA  - Neurosci Biobehav Rev
JT  - Neuroscience and biobehavioral reviews
JID - 7806090
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Hippocampus/*anatomy & histology
MH  - Humans
MH  - Image Processing, Computer-Assisted/methods
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Organ Size
MH  - Pattern Recognition, Automated
MH  - *Polymorphism, Single Nucleotide
MH  - Young Adult
OTO - NOTNLM
OT  - BDNF
OT  - BDNF Val66Met
OT  - Brain-derived neurotrophic factor
OT  - Hippocampus
OT  - MRI
OT  - Structural
OT  - rs6265
OT  - sMRI
EDAT- 2014/03/29 06:00
MHDA- 2015/07/16 06:00
CRDT- 2014/03/29 06:00
PHST- 2013/11/21 00:00 [received]
PHST- 2014/02/17 00:00 [revised]
PHST- 2014/03/16 00:00 [accepted]
PHST- 2014/03/29 06:00 [entrez]
PHST- 2014/03/29 06:00 [pubmed]
PHST- 2015/07/16 06:00 [medline]
AID - S0149-7634(14)00065-7 [pii]
AID - 10.1016/j.neubiorev.2014.03.011 [doi]
PST - ppublish
SO  - Neurosci Biobehav Rev. 2014 May;42:267-78. doi: 10.1016/j.neubiorev.2014.03.011. 
      Epub 2014 Mar 24.