PMID- 2467568 OWN - NLM STAT- MEDLINE DCOM- 19890502 LR - 20191029 IS - 8755-8920 (Print) IS - 8755-8920 (Linking) VI - 18 IP - 2 DP - 1988 Oct TI - Distribution of human leukocyte antigen-ABC and -D/DR antigens in the unfixed human testis. PG - 47-51 AB - The distribution of the major histocompatibility complex (MHC) antigens in the unfixed human testicle was studied by indirect immunofluorescence. Three murine monoclonal antibodies to the common determinants of class I MHC antigens (human leukocyte antigen [HLA]-ABC) and three against class II MHC antigens (HLA-D/DR antigens), respectively, were utilized. No class I MHC antigens were identified on developing testicular germ cells including spermatozoa, but interstitial cells between the seminiferous tubules (including Leydig cells) and blood vessel endothelium expressed the antigen. Class II MHC antigens were not found on any cells within the seminiferous tubules. However, the class II antigen was identified on dendritic-like cells between the seminiferous tubules and on vessel endothelium, although its expression was expectedly limited. These findings indicate that human testicular germ cells express minimal or no MHC antigens. FAU - Haas, G G Jr AU - Haas GG Jr AD - Department of Obstetrics and Gynecology, University of Oklahoma, Health Sciences Center, Oklahoma City. FAU - D'Cruz, O J AU - D'Cruz OJ FAU - De Bault, L E AU - De Bault LE LA - eng PT - Journal Article PL - United States TA - Am J Reprod Immunol Microbiol JT - American journal of reproductive immunology and microbiology : AJRIM JID - 8501543 RN - 0 (Antibodies, Monoclonal) RN - 0 (Epitopes) RN - 0 (Histocompatibility Antigens Class I) RN - 0 (Histocompatibility Antigens Class II) SB - IM MH - Adult MH - Antibodies, Monoclonal MH - Epitopes/immunology MH - Fluorescent Antibody Technique MH - Histocompatibility Antigens Class I/*analysis/immunology MH - Histocompatibility Antigens Class II/*analysis/immunology MH - Humans MH - Male MH - Testis/*immunology EDAT- 1988/10/01 00:00 MHDA- 2001/03/28 10:01 CRDT- 1988/10/01 00:00 PHST- 1988/10/01 00:00 [pubmed] PHST- 2001/03/28 10:01 [medline] PHST- 1988/10/01 00:00 [entrez] AID - 10.1111/j.1600-0897.1988.tb00234.x [doi] PST - ppublish SO - Am J Reprod Immunol Microbiol. 1988 Oct;18(2):47-51. doi: 10.1111/j.1600-0897.1988.tb00234.x.