PMID- 24676990
OWN - NLM
STAT- MEDLINE
DCOM- 20151012
LR  - 20220310
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Linking)
VI  - 231
IP  - 20
DP  - 2014 Oct
TI  - Oxidative stress and BDNF as possible markers for the severity of crack cocaine 
      use in early withdrawal.
PG  - 4031-9
LID - 10.1007/s00213-014-3542-1 [doi]
AB  - RATIONALE: An important goal of addiction research is to discover neurobiological 
      markers that could predict the severity of addiction and help to determine 
      appropriate treatment. Brain-derived neurotrophic factor (BDNF) and 
      thiobarbituric acid reactive substances (TBARS) are being related to cerebral 
      plasticity and impairment caused by substance abuse. OBJECTIVES: This study aims 
      to evaluate alteration of TBARS and BDNF levels among crack cocaine users during 
      early drug withdrawal and its relationship to severity of drug use. METHODS: 
      Forty-nine adults crack cocaine users were recruited at a public psychiatric 
      hospital with a specialized addiction treatment unit. Blood sample was collected 
      at intake and discharge for the analysis of TBARS and BDNF measures. Information 
      about drug use was assessed by the Addiction Severity Index 6th Version (ASI-6). 
      Detailed information about crack cocaine use was obtained through the "Profile of 
      the crack cocaine user." Severity of crack use was estimated using information 
      from age of first crack use, years of crack use, and crack rocks used in the 
      previous 30 days. RESULTS: There is a positive correlation between TBARS levels 
      and severity of crack cocaine use (R = 0.304, p = 0.04) and a negative 
      correlation between BDNF and severity of crack cocaine use (R = -0.359, p = 0.01) 
      at discharge. Also, we found an inverse correlation between TBARS and BDNF levels 
      (R = -0.294, p = 0.004) at discharge. CONCLUSIONS: Our findings suggest that BDNF 
      and TBARS could be possible markers for the severity of drug use. Further studies 
      may show how those markers could be related to staging, prognosis, and treatment 
      in crack cocaine dependence.
FAU - Sordi, Anne Orgle
AU  - Sordi AO
AD  - Center for Drug and Alcohol Research, Hospital de Clinicas de Porto Alegre 
      (HCPA), Universidade Federal do Rio Grande do Sul (UFRGS), Rua Prof. Alvaro 
      Alvim, 400, Porto Alegre, RS, CEP 90420-020, Brazil, annesordi@yahoo.com.br.
FAU - Pechansky, Flavio
AU  - Pechansky F
FAU - Kessler, Felix Henrique Paim
AU  - Kessler FH
FAU - Kapczinski, Flavio
AU  - Kapczinski F
FAU - Pfaffenseller, Bianca
AU  - Pfaffenseller B
FAU - Gubert, Carolina
AU  - Gubert C
FAU - de Aguiar, Bianca Wollenhaupt
AU  - de Aguiar BW
FAU - de Magalhaes Narvaez, Joana Correa
AU  - de Magalhaes Narvaez JC
FAU - Ornell, Felipe
AU  - Ornell F
FAU - von Diemen, Lisia
AU  - von Diemen L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140328
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Crack Cocaine)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cocaine-Related Disorders/diagnosis/*metabolism/psychology
MH  - *Crack Cocaine
MH  - Humans
MH  - Male
MH  - Oxidative Stress/*physiology
MH  - Severity of Illness Index
MH  - Substance Withdrawal Syndrome/*metabolism/psychology
MH  - Thiobarbituric Acid Reactive Substances/metabolism
MH  - Young Adult
EDAT- 2014/03/29 06:00
MHDA- 2015/10/13 06:00
CRDT- 2014/03/29 06:00
PHST- 2014/02/13 00:00 [received]
PHST- 2014/03/10 00:00 [accepted]
PHST- 2014/03/29 06:00 [entrez]
PHST- 2014/03/29 06:00 [pubmed]
PHST- 2015/10/13 06:00 [medline]
AID - 10.1007/s00213-014-3542-1 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2014 Oct;231(20):4031-9. doi: 
      10.1007/s00213-014-3542-1. Epub 2014 Mar 28.