PMID- 24678205
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140328
LR  - 20231110
IS  - 0976-9668 (Print)
IS  - 2229-7707 (Electronic)
IS  - 0976-9668 (Linking)
VI  - 5
IP  - 1
DP  - 2014 Jan
TI  - Clinico-immunological profile and their correlation with severity of atopic 
      dermatitis in Eastern Indian children.
PG  - 95-100
LID - 10.4103/0976-9668.127296 [doi]
AB  - OBJECTIVE: To study the clinical features, absolute eosinophil count, and total 
      immunoglobulin E (IgE) level and their association with severity of atopic 
      dermatitis in Eastern Indian children (Bihar). DESIGN: Prospective hospital-based 
      study. SETTINGS: Pediatrics out-patient Department (OPD) and Dermatology OPD of a 
      Tertiary Care Teaching Hospital located in Rohtas District of Bihar. The study 
      was carried out over a period of 2 years during January 2010 to December 2011. 
      PARTICIPANTS: One hundred and thirty two children aged 0 month to 15 years were 
      diagnosed with atopic dermatitis. MAIN OUTCOME: Demographic profile, common 
      clinical features, absolute eosinophil count, and total IgE level and their 
      correlation with severity of atopic dermatitis in Eastern Indian children. 
      RESULTS: Out of a total 1829 pediatric patients aged 0 month to 15 years with 
      some pediatric dermatoses, 132 (7.21%) had atopic dermatitis. Of 132 patients, 57 
      (43.2%) were boys and 75 (56.8%) were girls, with a male to female ratio 1:1.3. 
      Of these 29 were infants and 103 were children. Two (62.1%) patients belonged to 
      rural area whereas 50 (37.9%) belonged to urban area. Personal history, family 
      history (up to third degree relatives), and both personal and family history of 
      atopy were present in 43.18%, 33.34%, and 12.1% of the subjects respectively. 
      Majority (89.4%) of patients had onset before 5 years of age. In infantile Atopic 
      dermatitis (AD), mean age +/- SD at onset was 5.2 months +/- 3.01 months. In 
      infantile group, 8 (27.6%) had mild, 14 (48.3%) moderate, and 7 (24.1%) had 
      severe atopic dermatitis. Infantile AD had statistically significant higher 
      SCORing Atopic Dermatitis (SCORAD) index score in all three grades of severity of 
      the disease. One hundred and three patients had childhood AD, out of which 40 
      (38.8%) were boys and 63 (61.2%) were girls, with a male to female ratio 1:1.57. 
      In childhood AD, mean age +/- SD at onset of the disease was 3.47 years +/- 3.02 
      years. Sixty three (61.1%) belonged to rural area whereas 40 (38.9%) were from 
      urban area. One hundred and thirty (98%) patients presented with itching. Ninety 
      two (69.7%) patients had high absolute eosinophils count (AEC) with mean +/- SD of 
      1004.1 +/- 596.2 (range 325-2510). Eighty seven (65.9%) patients had increased 
      total serum immunoglobulin E (TsIgE) with mean +/- SD value of 1127.11 IU/ml +/- 
      731.69 IU/ml (range: 125-2680 IU/ml). CONCLUSION: Epidemiological data on atopic 
      dermatitis in India are mainly hospital-based, true-point prevalence in community 
      is still scanty. Although the prevalence of AD is considered to be increasing, it 
      still remains low in comparison to developed countries. In Indian children, the 
      disease is relatively milder than children of developed countries. This study 
      identified that both AEC and TsIgE increased significantly in about 66% patient 
      and directly correlated with the severity of the AD.
FAU - Kumar, Mani Kant
AU  - Kumar MK
AD  - Department of Pediatrics, Narayan Medical College and Hospital, Jamuhar, Sasaram, 
      Bihar, India.
FAU - Singh, Punit Kumar
AU  - Singh PK
AD  - Department of Dermatology, Narayan Medical College and Hospital, Jamuhar, 
      Sasaram, Bihar, India.
FAU - Patel, Pankaj Kumar
AU  - Patel PK
AD  - Department of Pathology, Narayan Medical College and Hospital, Jamuhar, Sasaram, 
      Bihar, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Nat Sci Biol Med
JT  - Journal of natural science, biology, and medicine
JID - 101571070
PMC - PMC3961961
OTO - NOTNLM
OT  - Absolute eosinophil count
OT  - Eastern Indian children
OT  - atopic dermatitis
OT  - total serum immunoglobulin E
COIS- Conflict of Interest: None declared.
EDAT- 2014/03/29 06:00
MHDA- 2014/03/29 06:01
PMCR- 2014/01/01
CRDT- 2014/03/29 06:00
PHST- 2014/03/29 06:00 [entrez]
PHST- 2014/03/29 06:00 [pubmed]
PHST- 2014/03/29 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - JNSBM-5-95 [pii]
AID - 10.4103/0976-9668.127296 [doi]
PST - ppublish
SO  - J Nat Sci Biol Med. 2014 Jan;5(1):95-100. doi: 10.4103/0976-9668.127296.