PMID- 24678247
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20231110
IS  - 1337-6853 (Print)
IS  - 1337-9569 (Electronic)
IS  - 1337-6853 (Linking)
VI  - 6
IP  - 3
DP  - 2013 Sep
TI  - Exposure to lipophilic chemicals as a cause of neurological impairments, 
      neurodevelopmental disorders and neurodegenerative diseases.
PG  - 103-10
LID - 10.2478/intox-2013-0018 [doi]
AB  - Many studies have associated environmental exposure to chemicals with 
      neurological impairments (NIs) including neuropathies, cognitive, motor and 
      sensory impairments; neurodevelopmental disorders (NDDs) including autism and 
      attention deficit hyperactivity disorder (ADHD); neurodegenerative diseases 
      (NDGs) including Alzheimer's disease, Parkinson's disease and amyotrophic lateral 
      sclerosis (ALS). The environmental chemicals shown to induce all these diseases 
      include persistent organic pollutants (POPs), the plastic exudates bisphenol A 
      and phthalates, low molecular weight hydrocarbons (LMWHCs) and polynuclear 
      aromatic hydrocarbons (PAHs). It is reported here that though these chemicals 
      differ widely in their chemical properties, reactivities and known points of 
      attack in humans, a common link does exist between them. All are lipophilic 
      species found in serum and they promote the sequential absorption of otherwise 
      non-absorbed toxic hydrophilic species causing these diseases.
FAU - Zeliger, Harold I
AU  - Zeliger HI
AD  - Zeliger Chemical, Toxicological, and Environmental Research, West Charlton, NY, 
      USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Slovakia
TA  - Interdiscip Toxicol
JT  - Interdisciplinary toxicology
JID - 101528175
PMC - PMC3967436
OTO - NOTNLM
OT  - ADHD
OT  - Alzheimer's disease
OT  - Parkinson's disease
OT  - autism
OT  - lipophilic chemicals
OT  - neurological disease
OT  - toxic chemicals
EDAT- 2014/03/29 06:00
MHDA- 2014/03/29 06:01
PMCR- 2013/09/01
CRDT- 2014/03/29 06:00
PHST- 2013/09/15 00:00 [received]
PHST- 2013/09/25 00:00 [revised]
PHST- 2013/09/30 00:00 [accepted]
PHST- 2014/03/29 06:00 [entrez]
PHST- 2014/03/29 06:00 [pubmed]
PHST- 2014/03/29 06:01 [medline]
PHST- 2013/09/01 00:00 [pmc-release]
AID - ITX-6-103 [pii]
AID - 10.2478/intox-2013-0018 [doi]
PST - ppublish
SO  - Interdiscip Toxicol. 2013 Sep;6(3):103-10. doi: 10.2478/intox-2013-0018.