PMID- 24678354
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140328
LR  - 20220318
IS  - 1911-6470 (Print)
IS  - 1920-1214 (Electronic)
IS  - 1911-6470 (Linking)
VI  - 8
IP  - 3-4
DP  - 2014 Mar-Apr
TI  - Age-stratified distribution of metastatic sites in bladder cancer: A 
      population-based analysis.
PG  - E148-58
LID - 10.5489/cuaj.787 [doi]
AB  - INTRODUCTION: Urothelial carcinoma of the urinary bladder (UCUB) is the most 
      common malignancy of the urinary tract. We examined the distribution of 
      site-specific metastases in patients with UCUB according to age and we assessed 
      contemporary recommendations proposed by guidelines with regard to distant 
      metastases. METHODS: Patients with metastatic UCUB (mUCUB) were abstracted from 
      the Nationwide Inpatient Sample (1998-2007). Age was stratified into quartiles: 
      </=63, 64-72, 73-79 and >/=80 years. Cochran-Armitage trend test and multivariable 
      logistic regression analysis tested the relationship between age and the rate of 
      metastases. Finally, we identified patients at high risk of brain or bone 
      metastases. RESULTS: Within 7543 patients with mUCUB, 25%, 24%, 23%, 19%, 18% and 
      3% had lymph node, bone, urinary, lung and liver metastases, respectively. 
      Overall, the rate of concomitant metastases was 29%. The rate of multiple 
      metastatic sites decreased with increasing age (p < 0.001). This was confirmed in 
      patients with lung, bone, liver, urinary system and brain metastases (all p </= 
      0.04). The rate of bone metastases was 15.0% in patients with exclusive abdominal 
      metastases and 40.0% in patients with abdominal, thoracic and brain metastases. 
      The rate of brain metastases was 1% in patients with exclusive abdominal 
      metastases and 7% in patients with thoracic and bone metastases. Our findings are 
      limited by the retrospective nature of the analyses. CONCLUSIONS: We report a 
      higher number of concomitant metastatic sites in young UCUB patients. Bone 
      metastases are frequent in all patient groups, whereas brain metastases are 
      common in UCUB patients with thoracic and/or bone metastases.
FAU - Bianchi, Marco
AU  - Bianchi M
AD  - Cancer Prognostics and Health Outcomes Unit, University of Montreal Health 
      Centre, Montreal, QC; ; Department of Urology, Vita-Salute San Raffaele 
      University, Milan, Italy;
FAU - Roghmann, Florian
AU  - Roghmann F
AD  - Cancer Prognostics and Health Outcomes Unit, University of Montreal Health 
      Centre, Montreal, QC; ; Department of Urology, Ruhr University Bochum, 
      Marienhospital, Herne, Germany;
FAU - Becker, Andreas
AU  - Becker A
AD  - Cancer Prognostics and Health Outcomes Unit, University of Montreal Health 
      Centre, Montreal, QC; ; Martini-Clinic, Prostate Cancer Center, 
      Hamburg-Eppendorf, Hamburg, Germany;
FAU - Sukumar, Shyam
AU  - Sukumar S
AD  - Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI;
FAU - Briganti, Alberto
AU  - Briganti A
AD  - Department of Urology, Vita-Salute University, Urological Research Institute, 
      Milan, Italy.
FAU - Menon, Mani
AU  - Menon M
AD  - Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI;
FAU - Karakiewicz, Pierre I
AU  - Karakiewicz PI
AD  - Cancer Prognostics and Health Outcomes Unit, University of Montreal Health 
      Centre, Montreal, QC; ; Department of Urology, University of Montreal Health 
      Centre, Montreal, QC;
FAU - Sun, Maxine
AU  - Sun M
AD  - Cancer Prognostics and Health Outcomes Unit, University of Montreal Health 
      Centre, Montreal, QC;
FAU - Noldus, Joachim
AU  - Noldus J
AD  - Department of Urology, Ruhr University Bochum, Marienhospital, Herne, Germany;
FAU - Trinh, Quoc-Dien
AU  - Trinh QD
AD  - Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI;
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Urol Assoc J
JT  - Canadian Urological Association journal = Journal de l'Association des urologues 
      du Canada
JID - 101312644
PMC - PMC3956834
EDAT- 2014/03/29 06:00
MHDA- 2014/03/29 06:01
PMCR- 2014/03/01
CRDT- 2014/03/29 06:00
PHST- 2014/03/29 06:00 [entrez]
PHST- 2014/03/29 06:00 [pubmed]
PHST- 2014/03/29 06:01 [medline]
PHST- 2014/03/01 00:00 [pmc-release]
AID - cuaj-3-4-e148 [pii]
AID - 10.5489/cuaj.787 [doi]
PST - ppublish
SO  - Can Urol Assoc J. 2014 Mar-Apr;8(3-4):E148-58. doi: 10.5489/cuaj.787.