PMID- 24678498
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140328
LR  - 20220316
IS  - 2288-176X (Print)
IS  - 2288-1778 (Electronic)
IS  - 2288-176X (Linking)
VI  - 10
IP  - 1
DP  - 2014 Feb
TI  - Treadmill exercise improves short-term memory by enhancing neurogenesis in 
      amyloid beta-induced Alzheimer disease rats.
PG  - 2-8
LID - 10.12965/jer.140086 [doi]
AB  - Alzheimer's disease is one of the most devastating neurodegenerative disorders, 
      and this disease is characterized by severe memory impairment and decline of 
      cognition. Hippocampal neurons are vulnerable to injury induced by Alzheimer's 
      disease. Physical exercise is known to promote cell survival and functional 
      recovery after brain injuries. In the present study, we investigated the effects 
      of treadmill exercise on short-term memory in relation with neurogenesis in the 
      rats with amyloid beta25-35 (Abeta25-35)-induced Alzheimer's disease. The rat model of 
      Alzheimer's disease was induced by the intracerebroventricular (ICV) injection of 
      Abeta25-35, using a stereotaxic instrument. The rats in the exercise group were 
      forced to run on a treadmill for 30 min once daily for 4 consecutive weeks, 
      starting 2 days after Abeta25-35 injection. Presently, short-term memory was 
      deteriorated and apical dendritic length in the hippocampus was shortened in the 
      hippocampus by Abeta25-35 injection. In contrast, treadmill exercise alleviated 
      memory impairment and increased apical dendritic length in the Abeta25-35-injected 
      rats. Neurogenesis and brain-derived neurotorphic factor (BDNF) and tyrosine 
      kinase B (trkB) in the hippocampal dentate gyrus were decreased by Abeta25-35 
      injection. Treadmill exercise increased neurogenesis and expressions of BDNF and 
      trkB expressions. The present study shows that treadmill exercise may provide 
      therapeutic value for the alleviating symptoms of Alzheimer's disease.
FAU - Kim, Bo-Kyun
AU  - Kim BK
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Shin, Mal-Soon
AU  - Shin MS
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Kim, Chang-Ju
AU  - Kim CJ
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Baek, Sang-Bin
AU  - Baek SB
AD  - Department of Psychiatry, Gangneung Asan Hospital, Ulsan University, Gangneung, 
      Korea.
FAU - Ko, Yeong-Chan
AU  - Ko YC
AD  - Faculty of Exercise & Sports Science, Jeju National University, Jeju, Korea.
FAU - Kim, Young-Pyo
AU  - Kim YP
AD  - Faculty of Exercise & Sports Science, Jeju National University, Jeju, Korea.
LA  - eng
PT  - Journal Article
DEP - 20140228
PL  - Korea (South)
TA  - J Exerc Rehabil
JT  - Journal of exercise rehabilitation
JID - 101615171
PMC - PMC3952831
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Apical dendritic length
OT  - Neurogenesis
OT  - Short-term memory
OT  - Treadmill exercise
EDAT- 2014/03/29 06:00
MHDA- 2014/03/29 06:01
PMCR- 2014/02/28
CRDT- 2014/03/29 06:00
PHST- 2014/01/15 00:00 [received]
PHST- 2014/01/28 00:00 [revised]
PHST- 2014/02/06 00:00 [accepted]
PHST- 2014/03/29 06:00 [entrez]
PHST- 2014/03/29 06:00 [pubmed]
PHST- 2014/03/29 06:01 [medline]
PHST- 2014/02/28 00:00 [pmc-release]
AID - jer-10-1-2-2 [pii]
AID - 10.12965/jer.140086 [doi]
PST - epublish
SO  - J Exerc Rehabil. 2014 Feb 28;10(1):2-8. doi: 10.12965/jer.140086. eCollection 
      2014 Feb.