PMID- 24678786
OWN - NLM
STAT- MEDLINE
DCOM- 20150619
LR  - 20221207
IS  - 1875-6638 (Electronic)
IS  - 1573-4064 (Linking)
VI  - 10
IP  - 8
DP  - 2014
TI  - Apolipoprotein E gene variants of Alzheimer's disease and vascular dementia 
      patients in a community population of Nanking.
PG  - 783-8
AB  - To explore apolipoprotein E gene variants distribution among the patients of 
      Alzheimer's disease and vascular dementia for the elderly community population in 
      Nanking, the polymerase chain reaction and restriction fragment length 
      polymorphism techniques were employed to analyze the gene frequency of 
      apolipoprotein E (ApoE) for 113 cases with Alzheimer's disease (AD), 85 cases 
      with vascular dementia (VaD), 147 cases with questionable dementia (QD), and 396 
      dementia-free controls. It was found that ApoE epsilon4 gene container (37.17%) and 
      allele frequency (21.24 +/- 2.72) of ApoE epsilon4 in AD group were significantly higher 
      than those in both control and VaD group (p < 0.05). With the increment of epsilon4 
      gene dose, the incidence of the AD was significantly increased. Compared with the 
      control group, ApoE epsilon4 had risk ratio (RR) of 1.82 to develop AD (p = 4e-4), and 
      attributable risk percentage (ARP) of 45%. These results suggest that ApoE epsilon4 
      gene may be responsible for up to 45% of the genetic component of Alzheimer's 
      disease, and may act as a discriminator between AD and VaD as well.
FAU - Chu, Wen-Zheng
AU  - Chu WZ
FAU - Gong, Li
AU  - Gong L
FAU - Xu, Ying-Qiu
AU  - Xu YQ
FAU - Cai, Guo-Hua
AU  - Cai GH
FAU - Chou, Kuo-Chen
AU  - Chou KC
AD  - First Affiliated Hospital with Nanking Medical University, Nanking, Jiangsu 
      Province, 210036 China. lcai2012@yeah.net.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Med Chem
JT  - Medicinal chemistry (Shariqah (United Arab Emirates))
JID - 101240303
RN  - 0 (Apolipoproteins E)
RN  - 0 (Protein Isoforms)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Alzheimer Disease/diagnosis/ethnology/*genetics/pathology
MH  - Apolipoproteins E/*genetics
MH  - Asian People
MH  - Case-Control Studies
MH  - Community Medicine
MH  - Dementia, Vascular/diagnosis/ethnology/*genetics/pathology
MH  - Diagnosis, Differential
MH  - Female
MH  - Gene Frequency
MH  - *Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Polymorphism, Restriction Fragment Length
MH  - Protein Isoforms/genetics
MH  - Risk
EDAT- 2014/04/01 06:00
MHDA- 2015/06/20 06:00
CRDT- 2014/04/01 06:00
PHST- 2014/01/01 00:00 [received]
PHST- 2014/03/21 00:00 [revised]
PHST- 2014/03/23 00:00 [accepted]
PHST- 2014/04/01 06:00 [entrez]
PHST- 2014/04/01 06:00 [pubmed]
PHST- 2015/06/20 06:00 [medline]
AID - MC-EPUB-59794 [pii]
AID - 10.2174/1573406410666140327120714 [doi]
PST - ppublish
SO  - Med Chem. 2014;10(8):783-8. doi: 10.2174/1573406410666140327120714.