PMID- 24679122
OWN - NLM
STAT- MEDLINE
DCOM- 20150515
LR  - 20211021
IS  - 1477-2205 (Electronic)
IS  - 1061-5806 (Print)
IS  - 1061-5806 (Linking)
VI  - 27
IP  - 6
DP  - 2014
TI  - Serotonin transporter and BDNF polymorphisms interact to predict trait worry.
PG  - 712-21
LID - 10.1080/10615806.2014.909928 [doi]
AB  - BACKGROUND AND OBJECTIVES: Excessive worry is associated with a range of 
      psychological disorders. While previous studies have examined genes associated 
      with a range of different anxiety phenotypes, none have explored genes 
      specifically associated with the general tendency to worry. DESIGN: The present 
      study tested associations between trait worry and functional polymorphisms of 
      three candidate genes: the serotonin transporter-linked polymorphic region 
      (5-HTTLPR) of the SLC6A4 gene, the Val66Met region of the brain-derived 
      neurotrophic factor (BDNF) gene, and the Val158Met region of the 
      catechol-O-methyltransferase (COMT) gene. METHODS: A heterogeneous sample of 
      adult participants (n=173) completed the Penn State Worry Questionnaire (PSWQ) 
      and provided DNA samples for genotyping. RESULTS: Results revealed a significant 
      interaction between 5-HTTLPR and BDNF genotypes predicting levels of worry. 
      Specifically, there was a significant positive association between 5-HTTLPR short 
      alleles and PSWQ scores, but only in BDNF met allele carriers. COMT genotype was 
      not significantly associated levels of worry, nor did COMT interact with 5-HTTLPR 
      or BDNF genotypes to predict PSWQ scores. CONCLUSIONS: These findings provide 
      preliminary evidence about the putative genetic etiology of worrying. Key 
      limitations of the present study and corresponding directions for future research 
      on this topic are discussed.
FAU - Bredemeier, Keith
AU  - Bredemeier K
AD  - a Providence Veterans Affairs Medical Center , Providence , RI , USA.
FAU - Beevers, Christopher G
AU  - Beevers CG
FAU - McGeary, John E
AU  - McGeary JE
LA  - eng
GR  - R01 DA032457/DA/NIDA NIH HHS/United States
GR  - R01MH076897/MH/NIMH NIH HHS/United States
GR  - 1S10RR023457-01A1/RR/NCRR NIH HHS/United States
GR  - S10 RR023457/RR/NCRR NIH HHS/United States
GR  - R01DA032457/DA/NIDA NIH HHS/United States
GR  - R01 MH076897/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20140425
PL  - England
TA  - Anxiety Stress Coping
JT  - Anxiety, stress, and coping
JID - 9212242
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (SLC6A4 protein, human)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - EC 2.1.1.6 (Catechol O-Methyltransferase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Anxiety/*genetics/psychology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Catechol O-Methyltransferase/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/genetics/psychology
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic/*genetics
MH  - Predictive Value of Tests
MH  - Serotonin Plasma Membrane Transport Proteins/*genetics
MH  - Surveys and Questionnaires
MH  - Young Adult
PMC - PMC4156552
MID - NIHMS583646
OTO - NOTNLM
OT  - 5-HTTLPR
OT  - BDNF
OT  - COMT
OT  - genetic association
OT  - worry
COIS- The authors do not have any conflicts of interest to disclose.
EDAT- 2014/04/01 06:00
MHDA- 2015/05/16 06:00
PMCR- 2015/11/01
CRDT- 2014/04/01 06:00
PHST- 2014/04/01 06:00 [entrez]
PHST- 2014/04/01 06:00 [pubmed]
PHST- 2015/05/16 06:00 [medline]
PHST- 2015/11/01 00:00 [pmc-release]
AID - 10.1080/10615806.2014.909928 [doi]
PST - ppublish
SO  - Anxiety Stress Coping. 2014;27(6):712-21. doi: 10.1080/10615806.2014.909928. Epub 
      2014 Apr 25.