PMID- 24679997
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20140804
IS  - 1878-4372 (Electronic)
IS  - 1360-1385 (Linking)
VI  - 19
IP  - 8
DP  - 2014 Aug
TI  - Redefining the metabolic continuity of chloroplasts and ER.
PG  - 501-7
LID - S1360-1385(14)00058-2 [pii]
LID - 10.1016/j.tplants.2014.02.013 [doi]
AB  - As a hub for plant metabolism, plastids extensively exchange metabolites with the 
      extraplastid environment. For polar metabolites, membrane transporters mediate 
      this exchange, but for many plastid-synthesized nonpolar compounds, such 
      transporters remain elusive. Here, we discuss recent data from transorganellar 
      complementation studies that demonstrate that enzymes in one organelle can 
      directly access nonpolar metabolites from a companion organelle. We propose that 
      a mechanism, based on hemifused-membranes at plastid-endoplasmic reticulum (ER) 
      contact sites, facilitates interorganellar interactions and allows enzymes 
      direct, transporter-independent access to a range of nonpolar compounds in both 
      organelle membranes. In a wider context, interorganellar metabolism at hemifusion 
      interfaces would allow evolution of membrane-spanning pathways for the many 
      thousands of nonpolar metabolites in the plant kingdom to be uncoupled from 
      coevolution with nonpolar metabolite transporters.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Mehrshahi, Payam
AU  - Mehrshahi P
AD  - Department of Biochemistry and Molecular Biology, Michigan State University, East 
      Lansing, MI 48824, USA.
FAU - Johnny, Cassandra
AU  - Johnny C
AD  - Department of Biochemistry and Molecular Biology, Michigan State University, East 
      Lansing, MI 48824, USA.
FAU - DellaPenna, Dean
AU  - DellaPenna D
AD  - Department of Biochemistry and Molecular Biology, Michigan State University, East 
      Lansing, MI 48824, USA. Electronic address: dellapen@msu.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20140326
PL  - England
TA  - Trends Plant Sci
JT  - Trends in plant science
JID - 9890299
SB  - IM
MH  - Biological Evolution
MH  - Chloroplasts/*metabolism
MH  - Endoplasmic Reticulum/*metabolism
MH  - Membrane Fusion
MH  - Models, Biological
MH  - Plant Cells/metabolism
OTO - NOTNLM
OT  - PLAM
OT  - hemifusion
OT  - interorganellar
OT  - nonpolar
OT  - transorganellar complementation
EDAT- 2014/04/01 06:00
MHDA- 2015/03/31 06:00
CRDT- 2014/04/01 06:00
PHST- 2013/12/20 00:00 [received]
PHST- 2014/02/20 00:00 [revised]
PHST- 2014/02/21 00:00 [accepted]
PHST- 2014/04/01 06:00 [entrez]
PHST- 2014/04/01 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
AID - S1360-1385(14)00058-2 [pii]
AID - 10.1016/j.tplants.2014.02.013 [doi]
PST - ppublish
SO  - Trends Plant Sci. 2014 Aug;19(8):501-7. doi: 10.1016/j.tplants.2014.02.013. Epub 
      2014 Mar 26.