PMID- 24680724
OWN - NLM
STAT- MEDLINE
DCOM- 20140715
LR  - 20161125
IS  - 1879-3185 (Electronic)
IS  - 0300-483X (Linking)
VI  - 321
DP  - 2014 Jul 3
TI  - Cross-omics gene and protein expression profiling in juvenile female mice 
      highlights disruption of calcium and zinc signalling in the brain following 
      dietary exposure to CB-153, BDE-47, HBCD or TCDD.
PG  - 1-12
LID - S0300-483X(14)00062-6 [pii]
LID - 10.1016/j.tox.2014.03.006 [doi]
AB  - The present study assessed if eating a diet of fish, spiked with persistent 
      organic pollutants (POPs), affects gene and protein expression in the maturing 
      mouse brain. Juvenile female Balb/c mice (22 days of age) were exposed for 28 
      days to fish-based diets spiked with the dioxin 2,3,7,8-tetrachlorodibenzodioxin 
      (TCDD) or the non dioxin-like (NDL) chemicals hexabromocyclodocecane (HBCD), 
      2,2'4,4'-tetrabromodiphenylether (BDE-47) or 2,2'4,4',5,5'-hexachlorobiphenyl 
      (CB-153) at doses approximating their respective lowest observed adverse effect 
      levels (LOAEL). It was found that all POPs elicited changes in neural gene and 
      protein expression profiles. Bioinformatic analysis of gene expression data 
      highlighted the importance of the aryl hydrocarbon receptor (AHR) in dioxin 
      toxicity and revealed that zinc regulation in the brain is targeted by TCDD 
      through the AHR. Calcium homeostasis was affected by both TCDD and the NDL 
      chemicals. In contrast to the transcriptomic analysis, the proteomics data did 
      not allow for a clear distinction between DL and NDL responses in the juvenile 
      brain but indicated that proteins associated with excitotoxicity were affected in 
      all exposure groups. Integrated interpretation of data led to the conclusion that 
      the dietary contaminants investigated in the present study breach the blood brain 
      barrier (BBB) and accumulate in the juvenile brain where they may induce 
      excitotoxic insults by dysregulation of the otherwise tightly controlled 
      homeostasis of calcium and zinc. Overall, the findings of the present study 
      highlight the need for further assessment of the risks associated with early life 
      exposure to foodborne POPs.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Rasinger, J D
AU  - Rasinger JD
AD  - Diabetes and Nutritional Sciences Division, School of Medicine, King's College 
      London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK; 
      National Institute of Nutrition and Seafood Research (NIFES), PO Box 2029, 
      Nordnes, 5817 Bergen, Norway. Electronic address: Josef.Rasinger@nifes.no.
FAU - Carroll, T S
AU  - Carroll TS
AD  - Diabetes and Nutritional Sciences Division, School of Medicine, King's College 
      London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK. 
      Electronic address: tc.informatics@gmail.com.
FAU - Lundebye, A K
AU  - Lundebye AK
AD  - National Institute of Nutrition and Seafood Research (NIFES), PO Box 2029, 
      Nordnes, 5817 Bergen, Norway. Electronic address: aha@nifes.no.
FAU - Hogstrand, C
AU  - Hogstrand C
AD  - Diabetes and Nutritional Sciences Division, School of Medicine, King's College 
      London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK. 
      Electronic address: christer.hogstrand@kcl.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140327
PL  - Ireland
TA  - Toxicology
JT  - Toxicology
JID - 0361055
RN  - 0 (Environmental Pollutants)
RN  - 0 (Flame Retardants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Brominated)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 0N97R5X10X (2,2',4,4'-tetrabromodiphenyl ether)
RN  - 5I9835JO3M (hexabromocyclododecane)
RN  - 63231-63-0 (RNA)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - J41CSQ7QDS (Zinc)
RN  - ZRU0C9E32O (2,4,5,2',4',5'-hexachlorobiphenyl)
SB  - IM
MH  - Algorithms
MH  - Animals
MH  - Brain Chemistry/drug effects/genetics
MH  - Calcium Signaling/*drug effects
MH  - Diet
MH  - Environmental Pollutants/*toxicity
MH  - Female
MH  - Flame Retardants/*toxicity
MH  - Gene Expression Profiling
MH  - Genomics
MH  - Halogenated Diphenyl Ethers/*pharmacology
MH  - Hydrocarbons, Brominated/*toxicity
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Polychlorinated Biphenyls/*pharmacology
MH  - Polychlorinated Dibenzodioxins/*pharmacology
MH  - Pregnancy
MH  - Proteomics
MH  - RNA/biosynthesis/isolation & purification
MH  - Signal Transduction/*drug effects
MH  - Transcription, Genetic/drug effects
MH  - Zinc/*physiology
OTO - NOTNLM
OT  - Dietary exposure
OT  - Gene expression
OT  - Juvenile brain
OT  - Persistent organic pollutants
OT  - Protein expression
EDAT- 2014/04/01 06:00
MHDA- 2014/07/16 06:00
CRDT- 2014/04/01 06:00
PHST- 2014/02/14 00:00 [received]
PHST- 2014/03/18 00:00 [revised]
PHST- 2014/03/18 00:00 [accepted]
PHST- 2014/04/01 06:00 [entrez]
PHST- 2014/04/01 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
AID - S0300-483X(14)00062-6 [pii]
AID - 10.1016/j.tox.2014.03.006 [doi]
PST - ppublish
SO  - Toxicology. 2014 Jul 3;321:1-12. doi: 10.1016/j.tox.2014.03.006. Epub 2014 Mar 
      27.