PMID- 24681217
OWN - NLM
STAT- MEDLINE
DCOM- 20150207
LR  - 20140609
IS  - 1095-6867 (Electronic)
IS  - 0018-506X (Linking)
VI  - 66
IP  - 1
DP  - 2014 Jun
TI  - Food hoarding, but not food intake, is attenuated by acute diazepam treatment in 
      female Mongolian gerbils (Meriones unguiculatus).
PG  - 186-95
LID - S0018-506X(14)00051-8 [pii]
LID - 10.1016/j.yhbeh.2014.03.010 [doi]
AB  - This article is part of a Special Issue "Energy Balance". Effects of 
      gamma-aminobutyric acid (GABA) on food hoarding are unknown in rodents, and the 
      effects of energy balance and GABA have not been evaluated in females. To 
      evaluate the role of food deprivation and GABA on food hoarding, female Mongolian 
      gerbils were given i.p. injection of diazepam (1mg/kg and 3mg/kg, respectively), 
      a GABAA receptor agonist. Among food-deprived females, there was a bimodal 
      pattern in the frequency of gerbils with different levels of food hoarding. High 
      food hoarding (HFH) and low food hoarding (LFH) gerbils were analyzed. Diazepam 
      blocked food deprivation-induced food hoarding in HFH gerbils, but not in LFH 
      gerbils. This blockade was associated with increased cellular activation in 
      selected brain areas, such as the nucleus accumbens (NAcc), caudate putamen (CP) 
      and ventral tegmental area (VTA), which suggested that direct activation of GABA 
      in the brain reward circuitry decreased food hoarding in HFH females. Moreover, 
      diazepam increased Fos expression in field CA2 and CA3 of the hippocampus, but 
      had no significant effect on Fos expression in field CA1 and dentate gyrus (DG) 
      of the hippocampus, indicating that the hippocampus has area-specific effects on 
      food hoarding in HFH gerbils. Diazepam did not alter food intake in both HFH and 
      LFH gerbils. In addition, serum corticosterone concentrations were higher in the 
      HFH than in the LFH ones. Together, these data indicated that food deprivation 
      increased food hoarding in female gerbils, diazepam reduced food 
      deprivation-induced food hoarding in HFH gerbils, and that GABA might influence 
      food hoarding via classical reward circuitry via the mesolimbic dopamine system 
      and specific hippocampal areas.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Yang, Hui-Di
AU  - Yang HD
AD  - State Key Laboratory of Integrated Management of Pest Insects and Rodents, 
      Institute of Zoology, Chinese Academy of Science, Beijing 100101, China; 
      Department of Physiology, Basic Medical College, Inner Mongolia Medical 
      University, Huhehaote 010110, China.
FAU - Wang, Qian
AU  - Wang Q
AD  - State Key Laboratory of Integrated Management of Pest Insects and Rodents, 
      Institute of Zoology, Chinese Academy of Science, Beijing 100101, China; Graduate 
      School of the Chinese Academy of Sciences, Yuquan Lu, Beijing 100049, China.
FAU - Wang, De-Hua
AU  - Wang DH
AD  - State Key Laboratory of Integrated Management of Pest Insects and Rodents, 
      Institute of Zoology, Chinese Academy of Science, Beijing 100101, China. 
      Electronic address: wangdh@ioz.ac.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140326
PL  - United States
TA  - Horm Behav
JT  - Hormones and behavior
JID - 0217764
RN  - 0 (GABA-A Receptor Agonists)
RN  - Q3JTX2Q7TU (Diazepam)
SB  - IM
MH  - Animals
MH  - Diazepam/administration & dosage/*pharmacology
MH  - Eating/*drug effects
MH  - Feeding Behavior/*drug effects
MH  - Female
MH  - Food Deprivation/physiology
MH  - GABA-A Receptor Agonists/administration & dosage/*pharmacology
MH  - Gerbillinae/*physiology
MH  - Hippocampus/*drug effects
MH  - Reward
OTO - NOTNLM
OT  - Diazepam
OT  - Food hoarding
OT  - GABA
OT  - Hippocampus
OT  - Reward circuitry
EDAT- 2014/04/01 06:00
MHDA- 2015/02/11 06:00
CRDT- 2014/04/01 06:00
PHST- 2013/11/08 00:00 [received]
PHST- 2014/02/26 00:00 [revised]
PHST- 2014/03/18 00:00 [accepted]
PHST- 2014/04/01 06:00 [entrez]
PHST- 2014/04/01 06:00 [pubmed]
PHST- 2015/02/11 06:00 [medline]
AID - S0018-506X(14)00051-8 [pii]
AID - 10.1016/j.yhbeh.2014.03.010 [doi]
PST - ppublish
SO  - Horm Behav. 2014 Jun;66(1):186-95. doi: 10.1016/j.yhbeh.2014.03.010. Epub 2014 
      Mar 26.