PMID- 24681540
OWN - NLM
STAT- MEDLINE
DCOM- 20150120
LR  - 20190720
IS  - 1347-5215 (Electronic)
IS  - 0918-6158 (Linking)
VI  - 37
IP  - 6
DP  - 2014
TI  - Antidepressant activity of astilbin: involvement of monoaminergic 
      neurotransmitters and BDNF signal pathway.
PG  - 987-95
AB  - Depression and related mood disorders are among the world's greatest public 
      health problems. Previous studies have demonstrated that astilbin (AST) has broad 
      pharmacological functions which may modulate numerous pathways, such as 
      antioxidant, scavenging free radicals, anti-inflammatory and so on, similarly to 
      some of other flavonoids. In this study, the antidepressant-like effect of AST 
      was investigated using chronic unpredictable mild stress (CUMS) model of 
      depression in mice. The results showed that chronic administration of AST at 
      doses of 10, 20 and 40 mg/kg (intraperitoneally (i.p.), 21 d) reduced 
      depressive-like behaviors of mice in the forced swim test (FST), tail suspension 
      test (TST) and sucrose preference test (SPT) without affecting locomotor 
      activity. AST increased the contents of serotonin (5-HT) and dopamine (DA) in the 
      frontal cortex of CUMS mice. Additionally, it was shown that AST treatment 
      restored the CUMS-induced inhibition of extracellular signal-regulated kinase 
      (ERK) 1/2 and AKT phosphorylation in the frontal cortex, conformed to the 
      brain-derived neurotrophic factor (BDNF) expression. Our findings suggest that 
      AST has antidepressant activities and the mechanisms, at least in part, relate to 
      up-regulation of monoaminergic neurotransmitters (5-HT and DA) and activation of 
      the BDNF signaling pathway.
FAU - Lv, Qiong-Qiong
AU  - Lv QQ
AD  - School of Pharmacy, Xinxiang Medical Univserity.
FAU - Wu, Wen-Jie
AU  - Wu WJ
FAU - Guo, Xiao-Liang
AU  - Guo XL
FAU - Liu, Rui-Li
AU  - Liu RL
FAU - Yang, Yu-Ping
AU  - Yang YP
FAU - Zhou, Du-Shuang
AU  - Zhou DS
FAU - Zhang, Ji-Xia
AU  - Zhang JX
FAU - Liu, Ju-Yuan
AU  - Liu JY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140328
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Antidepressive Agents)
RN  - 0 (Biogenic Monoamines)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Flavonols)
RN  - 29838-67-3 (astilbin)
RN  - 333DO1RDJY (Serotonin)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/administration & dosage/*therapeutic use
MH  - Behavior, Animal/*drug effects
MH  - Biogenic Monoamines/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Chronic Disease
MH  - Disease Models, Animal
MH  - Dopamine/metabolism
MH  - Flavonols/administration & dosage/*therapeutic use
MH  - Food Preferences/drug effects
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Motor Activity/drug effects
MH  - Serotonin/metabolism
MH  - Signal Transduction
MH  - Stress, Psychological/*drug therapy/psychology
MH  - Swimming
EDAT- 2014/04/01 06:00
MHDA- 2015/01/21 06:00
CRDT- 2014/04/01 06:00
PHST- 2014/04/01 06:00 [entrez]
PHST- 2014/04/01 06:00 [pubmed]
PHST- 2015/01/21 06:00 [medline]
AID - DN/JST.JSTAGE/bpb/b13-00968 [pii]
AID - 10.1248/bpb.b13-00968 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2014;37(6):987-95. doi: 10.1248/bpb.b13-00968. Epub 2014 Mar 28.