PMID- 24682420
OWN - NLM
STAT- MEDLINE
DCOM- 20141218
LR  - 20140414
IS  - 1791-244X (Electronic)
IS  - 1107-3756 (Linking)
VI  - 33
IP  - 6
DP  - 2014 Jun
TI  - Suppression of allergic and inflammatory responses by essential oils derived from 
      herbal plants and citrus fruits.
PG  - 1643-51
LID - 10.3892/ijmm.2014.1720 [doi]
AB  - The aim of the present study was to investigate the biological activity of 20 
      essential oils (EOs) derived from herbal plants and citrus fruits. The in vitro 
      anti-allergic and anti-inflammatory activities of these oils were investigated, 
      and the EO which was found to have the strongest activity of the 20 EOs examined, 
      was investigated further to identify its components and bioactive compounds. The 
      in vitro anti-allergic activity was determined by measuring the release of 
      beta-hexosaminidase from rat basophilic leukemia (RBL-2H3) cells treated with the 
      calcium ionophore, A23187. The in vitro anti-inflammatory activity was determined 
      by measuring the production of tumor necrosis factor-alpha (TNF-alpha) in RAW264.7 murine 
      macrophages treated with lipopolysaccharide. Among the EOs examined, lemongrass 
      [Cymbopogon citratus (DC.) Stapf] elicited the strongest anti-allergic and 
      anti-inflammatory effects. A principal component of this EO is citral 
      (3,7-dimethyl-2,6-octadien-1-al) (74.5%), a mixture of the stereoisomers, 
      geranial (trans-citral, 40.16%) and neral (cis-citral, 34.24%), as determined by 
      chromatography-mass spectrometry analysis. The activities of citral and geranial 
      are similar to those of lemongrass EO. These compounds elicited significant in 
      vivo anti-allergic and anti-inflammatory effects, suppressing an immunoglobulin E 
      (IgE)-induced passive cutaneous anaphylactic reaction in mice and a 
      12-O-tetradecanoylphorbol-13-acetate-induced inflammatory mouse ear edema, 
      respectively. Our data demonstrate that lemongrass EO and its constituents, 
      citral and geranial, may be a therapeutic candidate for allergic and inflammatory 
      diseases.
FAU - Mitoshi, Mai
AU  - Mitoshi M
AD  - Laboratory of Food and Nutritional Sciences, Faculty of Nutrition, Kobe Gakuin 
      University, Kobe, Hyogo 651‑2180, Japan.
FAU - Kuriyama, Isoko
AU  - Kuriyama I
AD  - Laboratory of Food and Nutritional Sciences, Faculty of Nutrition, Kobe Gakuin 
      University, Kobe, Hyogo 651‑2180, Japan.
FAU - Nakayama, Hiroto
AU  - Nakayama H
AD  - Research and Development Center, Nagaoka Perfumery Co., Ltd., Ibaraki, Osaka 
      567-0005, Japan.
FAU - Miyazato, Hironari
AU  - Miyazato H
AD  - Research and Development Center, Nagaoka Perfumery Co., Ltd., Ibaraki, Osaka 
      567-0005, Japan.
FAU - Sugimoto, Keiichiro
AU  - Sugimoto K
AD  - Research and Development Center, Nagaoka Perfumery Co., Ltd., Ibaraki, Osaka 
      567-0005, Japan.
FAU - Kobayashi, Yuko
AU  - Kobayashi Y
AD  - Department of Food and Nutrition, Faculty of Human Life Sciences, Senri Kinran 
      University, Suita, Osaka 565‑0873, Japan.
FAU - Jippo, Tomoko
AU  - Jippo T
AD  - Department of Food and Nutrition, Faculty of Human Life Sciences, Senri Kinran 
      University, Suita, Osaka 565‑0873, Japan.
FAU - Kuramochi, Kouji
AU  - Kuramochi K
AD  - Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, 
      Sakyo-ku, Kyoto 606-8522, Japan.
FAU - Yoshida, Hiromi
AU  - Yoshida H
AD  - Laboratory of Food and Nutritional Sciences, Faculty of Nutrition, Kobe Gakuin 
      University, Kobe, Hyogo 651‑2180, Japan.
FAU - Mizushina, Yoshiyuki
AU  - Mizushina Y
AD  - Laboratory of Food and Nutritional Sciences, Faculty of Nutrition, Kobe Gakuin 
      University, Kobe, Hyogo 651‑2180, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140331
PL  - Greece
TA  - Int J Mol Med
JT  - International journal of molecular medicine
JID - 9810955
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Oils, Volatile)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 37H9VM9WZL (Calcimycin)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/*therapeutic use
MH  - Calcimycin/pharmacology
MH  - Cell Line, Tumor
MH  - Citrus/*chemistry
MH  - Cymbopogon/*chemistry
MH  - Immunoglobulin E/metabolism
MH  - Inflammation/drug therapy
MH  - Mice
MH  - Oils, Volatile/*therapeutic use
MH  - Tumor Necrosis Factor-alpha/metabolism
EDAT- 2014/04/01 06:00
MHDA- 2014/12/19 06:00
CRDT- 2014/04/01 06:00
PHST- 2013/10/21 00:00 [received]
PHST- 2014/02/07 00:00 [accepted]
PHST- 2014/04/01 06:00 [entrez]
PHST- 2014/04/01 06:00 [pubmed]
PHST- 2014/12/19 06:00 [medline]
AID - 10.3892/ijmm.2014.1720 [doi]
PST - ppublish
SO  - Int J Mol Med. 2014 Jun;33(6):1643-51. doi: 10.3892/ijmm.2014.1720. Epub 2014 Mar 
      31.