PMID- 24682434
OWN - NLM
STAT- MEDLINE
DCOM- 20140609
LR  - 20211021
IS  - 1432-1211 (Electronic)
IS  - 0093-7711 (Linking)
VI  - 66
IP  - 5
DP  - 2014 May
TI  - HLA class I, KIR, and genome-wide SNP diversity in the RV144 Thai phase 3 HIV 
      vaccine clinical trial.
PG  - 299-310
LID - 10.1007/s00251-014-0765-6 [doi]
AB  - RV144 is the first phase 3 HIV vaccine clinical trial to demonstrate efficacy. 
      This study consisted of more than 8,000 individuals in each arm of the trial, 
      representing the four major regions of Thailand. Human leukocyte antigen (HLA) 
      class I and killer cell immunoglobulin-like receptor (KIR) genes, as well as 96 
      genome-wide ancestry informative markers (AIMs) were genotyped in 450 placebo 
      HIV-1-uninfected individuals to identify the immunogenetic diversity and 
      population structure of this cohort. High-resolution genotyping identified the 
      common HLA alleles as A*02:03, A*02:07, A*11:01, A*24:02, A*24:07, A*33:03, 
      B*13:01, B*15:02, B*18:01, B*40:01, B*44:03, B*46:01, B*58:01, C*01:02, C*03:02, 
      C*03:04, C*07:01, C*07:02, C*07:04, and C*08:01. The most frequent three-loci 
      haplotype was B*46:01-C*01:02-A*02:07. Framework genes KIR2DL4, 3DL2, and 3DL3 
      were present in all samples, and KIR2DL1, 2DL3, 3DL1, 2DS4, and 2DP1 occurred at 
      frequencies greater than 90 %. The combined HLA and KIR profile suggests 
      admixture with neighboring Asian populations. Principal component and 
      correspondence analyses comparing the RV144 samples to the phase 3 International 
      HapMap Project (HapMap3) populations using AIMs corroborated these findings. 
      Structure analyses identified a distinct profile in the Thai population that did 
      not match the Asian or other HapMap3 samples. This shows genetic variability 
      unique to Thais in RV144, making it essential to take into account population 
      stratification while performing genetic association studies. The overall analyses 
      from all three genetic markers indicate that the RV144 samples are representative 
      of the Thai population. This will inform subsequent host genetic analyses in the 
      RV144 cohort and provide insight for future genetic association studies in the 
      Thai population.
FAU - Prentice, Heather A
AU  - Prentice HA
AD  - U.S. Military HIV Research Program (MHRP), Walter Reed Army Institute of 
      Research, Silver Spring, MD, USA.
FAU - Ehrenberg, Philip K
AU  - Ehrenberg PK
FAU - Baldwin, Karen M
AU  - Baldwin KM
FAU - Geretz, Aviva
AU  - Geretz A
FAU - Andrews, Charla
AU  - Andrews C
FAU - Nitayaphan, Sorachai
AU  - Nitayaphan S
FAU - Rerks-Ngarm, Supachai
AU  - Rerks-Ngarm S
FAU - Kaewkungwal, Jaranit
AU  - Kaewkungwal J
FAU - Pitisuttithum, Punnee
AU  - Pitisuttithum P
FAU - O'Connell, Robert J
AU  - O'Connell RJ
FAU - Robb, Merlin L
AU  - Robb ML
FAU - Kim, Jerome H
AU  - Kim JH
FAU - Michael, Nelson L
AU  - Michael NL
FAU - Thomas, Rasmi
AU  - Thomas R
LA  - eng
PT  - Clinical Trial, Phase III
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20140329
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (AIDS Vaccines)
RN  - 0 (Genetic Markers)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - AIDS Vaccines/administration & dosage/*immunology
MH  - Alleles
MH  - Epistasis, Genetic
MH  - Gene Frequency
MH  - Genetic Markers
MH  - Genotype
MH  - HIV Infections/*genetics/*prevention & control
MH  - HIV-1/*immunology
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - *Polymorphism, Single Nucleotide
MH  - Receptors, KIR/*genetics
EDAT- 2014/04/01 06:00
MHDA- 2014/06/10 06:00
CRDT- 2014/04/01 06:00
PHST- 2013/12/14 00:00 [received]
PHST- 2014/02/23 00:00 [accepted]
PHST- 2014/04/01 06:00 [entrez]
PHST- 2014/04/01 06:00 [pubmed]
PHST- 2014/06/10 06:00 [medline]
AID - 10.1007/s00251-014-0765-6 [doi]
PST - ppublish
SO  - Immunogenetics. 2014 May;66(5):299-310. doi: 10.1007/s00251-014-0765-6. Epub 2014 
      Mar 29.