PMID- 24682912
OWN - NLM
STAT- MEDLINE
DCOM- 20150622
LR  - 20211021
IS  - 1720-8386 (Electronic)
IS  - 0391-4097 (Linking)
VI  - 37
IP  - 5
DP  - 2014 May
TI  - Serum uric acid is associated with arterial stiffness in men with newly diagnosed 
      type 2 diabetes mellitus.
PG  - 441-7
LID - 10.1007/s40618-013-0034-9 [doi]
AB  - BACKGROUND: Increased serum uric acid levels and vascular atherosclerosis are 
      very common in diabetes. However, few studies focused on the relationship between 
      serum uric acid and aortic or peripheral arterial stiffness in newly diagnosed 
      diabetic patients. This study investigated the association between serum uric 
      acid levels and carotid-femoral pulse wave velocity (cfPWV) or carotid-radial 
      (cr) PWV in male patients with newly diagnosed type 2 diabetes mellitus (T2DM). 
      METHODS: 106 male patients with newly diagnosed T2DM were recruited. cfPWV and 
      crPWV as well as anthropometric parameters, blood pressure, serum uric acid, 
      blood glucose, fasting insulin, C-reactive protein and blood lipids were 
      measured. RESULTS: The subjects were divided into low uric acid (UA) subgroup and 
      high UA subgroup according to uric acid median. cfPWV and crPWV were 
      significantly higher in high UA subgroup. Serum uric acid significantly 
      correlated with cfPWV (r = 0.533, P < 0.001), crPWV (r = 0.334, P = 0.001), waist 
      circumference (r = 0.350, P < 0.001), waist-to-hip ratio (r = 0.254, P = 0.009), 
      fasting insulin (r = 0.432, P < 0.001), HOMA-IR (r = 0.173, P = 0.042), fasting 
      blood glucose (r = -0.271, P = 0.005), haemoglobin A1c (r = -0.202, P = 0.038), 
      and HDL-cholesterol (r = -0.267, P = 0.006) after correction for age. Stepwise 
      multiple regressions showed that the independent determinants of cfPWV were serum 
      uric acid, age, C-reactive protein, HDL-cholesterol, and smoking status. And the 
      independent determinants of crPWV were serum uric acid, age, diastolic blood 
      pressure, and HDL-cholesterol. CONCLUSIONS: Serum uric acid is significantly 
      associated with increased aortic and peripheral arterial stiffness in men with 
      T2DM at the early stage.
FAU - Zhang, J
AU  - Zhang J
AD  - Department of Endocrinology, Wuhan General Hospital of Guangzhou Command, Wuluo 
      Road 627, Wuhan, 430070, Hubei, People's Republic of China, zhangjx666@gmail.com.
FAU - Xiang, G
AU  - Xiang G
FAU - Xiang, L
AU  - Xiang L
FAU - Sun, H
AU  - Sun H
LA  - eng
PT  - Journal Article
DEP - 20140109
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - 268B43MJ25 (Uric Acid)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Atherosclerosis/complications/*diagnosis/epidemiology
MH  - C-Reactive Protein/analysis
MH  - Carotid Arteries/physiopathology
MH  - China/epidemiology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/*complications/immunology/physiopathology
MH  - Diabetic Angiopathies/complications/*diagnosis/epidemiology
MH  - Early Diagnosis
MH  - Femoral Artery/physiopathology
MH  - Humans
MH  - Hyperuricemia/*complications/diagnosis
MH  - Insulin Resistance
MH  - Male
MH  - Middle Aged
MH  - Pulse Wave Analysis
MH  - Radial Artery/physiopathology
MH  - Risk Factors
MH  - Smoking/adverse effects
MH  - Uric Acid/*blood
MH  - *Vascular Stiffness
EDAT- 2014/04/01 06:00
MHDA- 2015/06/24 06:00
CRDT- 2014/04/01 06:00
PHST- 2013/03/16 00:00 [received]
PHST- 2013/11/17 00:00 [accepted]
PHST- 2014/04/01 06:00 [entrez]
PHST- 2014/04/01 06:00 [pubmed]
PHST- 2015/06/24 06:00 [medline]
AID - 10.1007/s40618-013-0034-9 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 2014 May;37(5):441-7. doi: 10.1007/s40618-013-0034-9. Epub 
      2014 Jan 9.