PMID- 24682952
OWN - NLM
STAT- MEDLINE
DCOM- 20140819
LR  - 20220318
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 35
IP  - 6
DP  - 2014 Jun
TI  - MiR-203 is downregulated in laryngeal squamous cell carcinoma and can suppress 
      proliferation and induce apoptosis of tumours.
PG  - 5953-63
LID - 10.1007/s13277-014-1790-7 [doi]
AB  - MicroRNAs (miRNAs) have been recognised to regulate cancer development and 
      progression in carcinogenesis as either oncogenes or tumour suppressor genes. 
      However, whether miR-203 plays a crucial role in human laryngeal squamous cell 
      carcinoma (LSCC) remains largely unclear. In the study, we have found that 
      miR-203 expression was significantly lower in LSCC tissues than that in 
      corresponding adjacent non-neoplastic tissues and was negatively correlated with 
      ASAP1 expression level. Lower expression of miR-203 was significantly related to 
      poor differentiation, advanced clinical stages, T3-4 tumour grade, lymph node 
      metastasis and decreased 5-year overall survival. Transfection with miR-203 
      inhibited proliferation, reduced invasion, induced apoptosis and caused G1 phase 
      cell cycle arrest of Hep-2 cells in vitro, suggesting that miR-203 functioned as 
      a tumour suppressor. We have also tested that over-expression of miR-203 may both 
      suppress the growth of xenograft tumours in mice and downregulate the expressions 
      of ASAP1 in vivo. Furthermore, miR-203 may regulate the expressions of 
      mesenchymal transition (EMT) marker of E-cadherin and cancer stem cells (CSCs) 
      marker of CD44. These findings suggest that miR-203 plays a role as a tumour 
      suppressor in LSCC, likely by regulating ASAP1, probably in relation to EMT and 
      CSCs and may serve as a potential target for therapeutic intervention.
FAU - Tian, Linli
AU  - Tian L
AD  - Department of Otolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University, Harbin, China.
FAU - Li, Minghua
AU  - Li M
FAU - Ge, Jingchun
AU  - Ge J
FAU - Guo, Yan
AU  - Guo Y
FAU - Sun, Yanan
AU  - Sun Y
FAU - Liu, Ming
AU  - Liu M
FAU - Xiao, Hui
AU  - Xiao H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140401
PL  - Netherlands
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental 
      Biology and Medicine
JID - 8409922
RN  - 0 (ASAP1 protein, human)
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (CD44 protein, human)
RN  - 0 (Cadherins)
RN  - 0 (Hyaluronan Receptors)
RN  - 0 (MIRN203 microRNA, human)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/analysis
MH  - Adult
MH  - Aged
MH  - Animals
MH  - *Apoptosis
MH  - Cadherins/analysis
MH  - Carcinoma, Squamous Cell/*pathology
MH  - *Cell Proliferation
MH  - Down-Regulation
MH  - Epithelial-Mesenchymal Transition
MH  - Female
MH  - Genes, Tumor Suppressor/*physiology
MH  - Head and Neck Neoplasms/*pathology
MH  - Humans
MH  - Hyaluronan Receptors/analysis
MH  - Laryngeal Neoplasms/*pathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - MicroRNAs/analysis/*physiology
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Squamous Cell Carcinoma of Head and Neck
EDAT- 2014/04/01 06:00
MHDA- 2014/08/20 06:00
CRDT- 2014/04/01 06:00
PHST- 2013/12/02 00:00 [received]
PHST- 2014/02/21 00:00 [accepted]
PHST- 2014/04/01 06:00 [entrez]
PHST- 2014/04/01 06:00 [pubmed]
PHST- 2014/08/20 06:00 [medline]
AID - 10.1007/s13277-014-1790-7 [doi]
PST - ppublish
SO  - Tumour Biol. 2014 Jun;35(6):5953-63. doi: 10.1007/s13277-014-1790-7. Epub 2014 
      Apr 1.