PMID- 24683011
OWN - NLM
STAT- MEDLINE
DCOM- 20140623
LR  - 20151119
IS  - 1470-7926 (Electronic)
IS  - 1351-0711 (Linking)
VI  - 71
IP  - 6
DP  - 2014 Jun
TI  - Exhaled nitric oxide in spray painters exposed to isocyanates: effect 
      modification by atopy and smoking.
PG  - 415-22
LID - 10.1136/oemed-2013-101672 [doi]
AB  - BACKGROUND: Isocyanate asthma is one of the most frequently identified forms of 
      occupational asthma in industrialised countries. The underlying mechanisms have 
      not been clarified. There is only limited information about the relationship 
      between exhaled nitric oxide (eNO) and occupational exposure to isocyanates and 
      asthma. OBJECTIVES: To investigate the association between isocyanate exposure 
      and eNO levels in isocyanate-exposed workers and to elucidate whether eNO acts as 
      a marker of airway inflammation controlling for smoking and atopy in an 
      industry-wide survey. METHODS: Information on estimated personal isocyanate 
      exposure, measured eNO levels, health effects and sensitisation were analysed in 
      229 workers from a cross-sectional study. Univariate and multiple regression 
      analyses were used to explore the exposure-response relationships between 
      isocyanate exposure and eNO, stratified by smoking and atopy. RESULTS: A 
      marginally significant exposure-response relationship was found between 
      isocyanate exposure and eNO in atopic, non-smokers (p=0.054). eNO was 
      significantly associated with atopy and smoking, bronchial hyper-responsiveness 
      (BHR), work-related conjunctivitis and rhinitis after adjustment for age, gender, 
      atopy and smoking (p<0.05). A borderline significant association was found 
      between eNO and asthma-like symptoms after adjustment for age, gender, atopy and 
      current smoking (p=0.055). In a small group of isocyanate-exposed workers with 
      positive serum-specific immunoglobulin E (IgE) antibodies to hexamethylene 
      diisocyanate (HDI), elevated eNO levels were clearly exposure related. eNO was 
      associated with the positive specific IgG antibodies to HDI in non-atopic, 
      non-smokers (p=0.03). CONCLUSIONS: Increased eNO levels may indicate increased 
      airway inflammation in atopic, non-smokers exposed to isocyanates especially at 
      higher levels of isocyanate exposure.
FAU - Jonaid, Badri Sadat
AU  - Jonaid BS
AD  - Division of Environmental Epidemiology, Institute for Risk Assessment Sciences 
      (IRAS), Utrecht University, The Netherlands.
FAU - Pronk, Anjoeka
AU  - Pronk A
FAU - Doekes, Gert
AU  - Doekes G
FAU - Heederik, Dick
AU  - Heederik D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140328
PL  - England
TA  - Occup Environ Med
JT  - Occupational and environmental medicine
JID - 9422759
RN  - 0 (Biomarkers)
RN  - 0 (Immunoglobulins)
RN  - 0 (Isocyanates)
RN  - 0I70A3I1UF (1,6-hexamethylene diisocyanate)
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Adult
MH  - Asthma/*etiology/immunology/metabolism
MH  - Biomarkers/metabolism
MH  - Conjunctivitis/metabolism
MH  - Cross-Sectional Studies
MH  - Exhalation
MH  - Female
MH  - Humans
MH  - Hypersensitivity, Immediate/metabolism
MH  - Immunoglobulins/blood
MH  - Inflammation/etiology/metabolism
MH  - Isocyanates/*adverse effects/immunology
MH  - Male
MH  - Middle Aged
MH  - Nitric Oxide/*metabolism
MH  - Occupational Diseases/*etiology/immunology/metabolism
MH  - Occupational Exposure/*adverse effects
MH  - *Paint
MH  - Rhinitis/metabolism
MH  - Smoking/*metabolism
EDAT- 2014/04/01 06:00
MHDA- 2014/06/24 06:00
CRDT- 2014/04/01 06:00
PHST- 2014/04/01 06:00 [entrez]
PHST- 2014/04/01 06:00 [pubmed]
PHST- 2014/06/24 06:00 [medline]
AID - oemed-2013-101672 [pii]
AID - 10.1136/oemed-2013-101672 [doi]
PST - ppublish
SO  - Occup Environ Med. 2014 Jun;71(6):415-22. doi: 10.1136/oemed-2013-101672. Epub 
      2014 Mar 28.