PMID- 24683237
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140331
LR  - 20240420
IS  - 0011-393X (Print)
IS  - 0011-393X (Linking)
VI  - 70
IP  - 4
DP  - 2009 Aug
TI  - Comparison of mitomycin C and limbal-conjunctival autograft in the prevention of 
      pterygial recurrence in Turkish patients: A one-year, randomized, 
      assessor-masked, controlled trial.
PG  - 274-81
LID - 10.1016/j.curtheres.2009.08.004 [doi]
AB  - BACKGROUND: A pterygium is a fibrovascular overgrowth of degenerative bulbar 
      conjunctival tissue that grows over the limbus onto the cornea. Although various 
      approaches have been proposed for the treatment of pterygium, the common problem 
      after these treatments is recurrence. OBJECTIVES: The goals of this study were to 
      compare the efficacy of mitomycin C (MMC) and limbal-conjunctival autograft 
      (LCAU) in preventing recurrence of primary pterygia and to monitor long-term 
      adverse effects (AEs). METHODS: Patients undergoing pterygium surgery between 
      February 2006 and May 2007 were assessed prospectively and randomly divided into 
      2 groups using a random number table. The MMC group underwent pterygium excision 
      and received 0.02% MMC intraoperatively for 2 minutes. The LCAU group underwent 
      pterygium excision and LCAU. Recurrence and AE rates of the 2 treatments were 
      compared during the 1-year follow-up period. Assessors for pterygial recurrence 
      were masked to treatment group. RESULTS: One hundred thirteen eyes (57 patients 
      in the MMC group and 56 patients in the LCAU group) were included in the study. 
      Thirteen of the patients (7 in the MMC group and 6 in the LCAU group) were 
      withdrawn due to irregular attendance at follow-up visits or lack of sufficient 
      dose and duration for postoperative topical antibiotic and steroid 
      administration; their data were excluded from analysis. Fifty patients (MMC 
      group: 26 men, 24 women; mean [SD] age, 48.0 [12.3] years; age range, 30-73 
      years; LCAU group: 27 men, 23 women; mean age, 49.0 [12.6] years; age range, 
      28-71 years) in each group completed the study. The mean (SD) length of the 
      pterygium across the limbus was similar in the MMC group and the LCAU group (4.18 
      [1.27] vs 4.07 [1.24] mm). The mean follow-up period was also similar in the 2 
      groups (16.0 [1.9] vs 15.0 [1.7] months). The rate of recurrence was 
      significantly greater in the MMC group than in the LCAU group (10 [20.0%] vs 2 
      [4.0%] patients; P=0.035). Seven patients (14.0%) in the MMC group experienced 
      AEs: conjunctival cyst (3 patients), symblepharon (2), conjunctival granuloma 
      (1), and dellen (1). In the LCAU group, 1 patient (2.0%; P=0.032 vs MMC group) 
      experienced permanent graft edema. All patients in the LCAU group experienced 
      transient graft edema, with recovery occurring in 3 to 4 weeks. There were no 
      intraoperative complications and there was no graft rejection. CONCLUSIONS: 
      Recurrence and postoperative AEs were less frequently observed in primary 
      excision with LCAU than with MMC in these Turkish patients who completed the 
      study. This study found that pterygium excision with LCAU was well tolerated and 
      effective in these patients.
FAU - Ari, Seyhmus
AU  - Ari S
AD  - Department of Ophthalmology, Diyarbakir State Hospital, Diyarbakir, Turkey.
FAU - Caca, Ihsan
AU  - Caca I
AD  - Department of Ophthalmology, Dicle University Faculty of Medicine, Diyarbakir, 
      Turkey.
FAU - Yildiz, Zennure Ozdemir
AU  - Yildiz ZO
AD  - Department of Ophthalmology, Diyarbakir State Hospital, Diyarbakir, Turkey.
FAU - Sakalar, Yildirim Bayezit
AU  - Sakalar YB
AD  - Department of Ophthalmology, Dicle University Faculty of Medicine, Diyarbakir, 
      Turkey.
FAU - Dogan, Eyup
AU  - Dogan E
AD  - Department of Ophthalmology, Dicle University Faculty of Medicine, Diyarbakir, 
      Turkey.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Curr Ther Res Clin Exp
JT  - Current therapeutic research, clinical and experimental
JID - 0372621
PMC - PMC3967336
OTO - NOTNLM
OT  - limbal-conjunctival autograft
OT  - mitomycin C
OT  - pterygium
EDAT- 2009/08/01 00:00
MHDA- 2009/08/01 00:01
PMCR- 2009/08/01
CRDT- 2014/04/01 06:00
PHST- 2009/06/15 00:00 [accepted]
PHST- 2014/04/01 06:00 [entrez]
PHST- 2009/08/01 00:00 [pubmed]
PHST- 2009/08/01 00:01 [medline]
PHST- 2009/08/01 00:00 [pmc-release]
AID - S0011-393X(09)00074-5 [pii]
AID - 10.1016/j.curtheres.2009.08.004 [doi]
PST - ppublish
SO  - Curr Ther Res Clin Exp. 2009 Aug;70(4):274-81. doi: 
      10.1016/j.curtheres.2009.08.004.