PMID- 24683256
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140331
LR  - 20211021
IS  - 0011-393X (Print)
IS  - 0011-393X (Linking)
VI  - 71
IP  - 2
DP  - 2010 Apr
TI  - Effects of a topical hemostatic agent on an epistaxis model in rabbits.
PG  - 105-10
LID - 10.1016/j.curtheres.2010.03.003 [doi]
AB  - BACKGROUND: Ankaferd BloodStopper (ABS) is a standardized herbal compound 
      consisting of 5 different plant extracts. ABS, as a topical medicinal product, 
      has been approved by the Turkish Ministry of Health for the management of dermal, 
      external postsurgical and postdental surgery bleedings. OBJECTIVE: The aim of 
      this study was to assess the hemostatic effect of ABS in an experimental 
      epistaxis model. METHODS: Adult female New Zealand rabbits were used in this 
      study. Standardized full-thickness mucosal wounds were created to provide 
      bleeding on the right and left side of the nasal septum of rabbits with a 3-mm 
      surgical punch. To stop bleeding, the wounds were treated with topical ABS on one 
      side and with topical isotonic saline solution as a control on the other side of 
      the nasal septum. Investigators were blinded to treatment. The duration of 
      bleeding was measured in order to compare the hemo-static effect with ABS or 
      topical isotonic saline solution. The wounds were observed for the duration of 
      bleeding in order to compare the hemostatic effect of ABS with isotonic saline 
      solution and acute adverse effects (AEs) for 30 minutes by a researcher blinded 
      to treatment groups. RESULTS: Six rabbits (mean weight, 2.6 kg [range, 2.3-3.1 
      kg]) were used in this study. Mean (SD) bleeding time in the wounds administered 
      ABS (98 [17] sec) was significantly less than that of the controls (266 [36] sec; 
      P = 0.004). No AEs were observed up to 30 minutes after study initiation. 
      CONCLUSION: This study suggests that ABS may be more effective in reducing time 
      to hemostasis when compared with isotonic saline solution in this epistaxis model 
      in rabbits.
FAU - Kurtaran, Hanifi
AU  - Kurtaran H
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Fatih University Faculty 
      of Medicine, Ankara, Turkey.
FAU - Ark, Nebil
AU  - Ark N
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Fatih University Faculty 
      of Medicine, Ankara, Turkey.
FAU - Serife Ugur, K
AU  - Serife Ugur K
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Fatih University Faculty 
      of Medicine, Ankara, Turkey.
FAU - Sert, Huseyin
AU  - Sert H
AD  - Department of Anesthesiology, Fatih University Faculty of Medicine, Ankara, 
      Turkey.
FAU - Ozboduroglu, Akin Altug
AU  - Ozboduroglu AA
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Fatih University Faculty 
      of Medicine, Ankara, Turkey.
FAU - Kosar, Ali
AU  - Kosar A
AD  - Department of Hematology, Fatih University Faculty of Medicine, Ankara, Turkey.
FAU - Gunduz, Mehmet
AU  - Gunduz M
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Fatih University Faculty 
      of Medicine, Ankara, Turkey.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Curr Ther Res Clin Exp
JT  - Current therapeutic research, clinical and experimental
JID - 0372621
PMC - PMC3967325
OTO - NOTNLM
OT  - Ankaferd BloodStopper
OT  - epistaxis
OT  - experimental
OT  - hemostasis
EDAT- 2010/04/01 00:00
MHDA- 2010/04/01 00:01
PMCR- 2010/04/01
CRDT- 2014/04/01 06:00
PHST- 2010/02/22 00:00 [accepted]
PHST- 2014/04/01 06:00 [entrez]
PHST- 2010/04/01 00:00 [pubmed]
PHST- 2010/04/01 00:01 [medline]
PHST- 2010/04/01 00:00 [pmc-release]
AID - S0011-393X(10)00037-8 [pii]
AID - 10.1016/j.curtheres.2010.03.003 [doi]
PST - ppublish
SO  - Curr Ther Res Clin Exp. 2010 Apr;71(2):105-10. doi: 
      10.1016/j.curtheres.2010.03.003.