PMID- 24683323
OWN - NLM
STAT- MEDLINE
DCOM- 20141218
LR  - 20211021
IS  - 1537-744X (Electronic)
IS  - 2356-6140 (Print)
IS  - 1537-744X (Linking)
VI  - 2014
DP  - 2014
TI  - A novel role of globular adiponectin in treatment with HFD/STZ induced T2DM 
      combined with NAFLD rats.
PG  - 230835
LID - 10.1155/2014/230835 [doi]
LID - 230835
AB  - AIMS: To evaluate the effects of globular adiponectin (gAd) on treatment of type 
      2 diabetic rats combined with NAFLD. MATERIALS AND METHODS: Twenty-one male 
      wistar rats were fed with normal diet (7 rats) or high fat diet (HFD) (14 rats) 
      for 4 weeks, and then HFD-fed rats were injected with streptozotocin (STZ) to 
      induce type 2 diabetes mellitus (T2DM). Half of T2DM rats were randomly injected 
      with gAd intraperitoneally for 7 days. The expressions of adiponectin receptors 
      (adipoR1/R2) in liver and skeletal muscle tissues were detected through western 
      blotting or RT-qPCR, respectively. RESULTS: Globular adiponectin alleviated the 
      hepatic steatosis and increased insulin secretion. In liver, both the protein and 
      mRNA expressions of adipoR2 in T2DM group decreased (P < 0.05, resp.) in contrast 
      to NC group and increased (P < 0.05 and P < 0.001, resp.) after gAd treatment. 
      But the protein and mRNA expressions of adipoR1 increased (P < 0.05, resp.) in 
      T2DM group and no change was found in the gAd-treated group. In skeletal muscle, 
      the protein and mRNA expressions of adipoR1 and adipoR2 were upregulated in T2DM 
      group and were downregulated after gAd treatment. CONCLUSIONS: Globular 
      adiponectin could ameliorate the hepatic steatosis and vary the expressions of 
      adiponectin receptors in liver and skeletal muscle by stimulating insulin 
      secretion.
FAU - Ma, Hong
AU  - Ma H
AUID- ORCID: 0000-0003-4415-694X
AD  - Department of Endocrinology, Zhongshan Hospital Xiamen University, 209 Hubin 
      South Road, Xiamen, Fujian 361004, China ; Department of Endocrinology, Xiamen 
      Zhongshan Teaching Hospital of Fujian Medical University, Xiamen, Fujian 361004, 
      China.
FAU - You, Guo-Ping
AU  - You GP
AD  - Department of Endocrinology, Zhongshan Hospital Xiamen University, 209 Hubin 
      South Road, Xiamen, Fujian 361004, China ; Department of Endocrinology, Xiamen 
      Zhongshan Teaching Hospital of Fujian Medical University, Xiamen, Fujian 361004, 
      China.
FAU - Zhang, Xuan-Pu
AU  - Zhang XP
AD  - Department of Endocrinology, Zhongshan Hospital Xiamen University, 209 Hubin 
      South Road, Xiamen, Fujian 361004, China ; Department of Endocrinology, Xiamen 
      Zhongshan Teaching Hospital of Fujian Medical University, Xiamen, Fujian 361004, 
      China.
FAU - Yang, Xiang-Jiu
AU  - Yang XJ
AD  - Department of Endocrinology, Zhongshan Hospital Xiamen University, 209 Hubin 
      South Road, Xiamen, Fujian 361004, China.
FAU - Lu, Hua-Dong
AU  - Lu HD
AD  - Department of Pathology, Zhongshan Hospital Xiamen University, Xiamen, Fujian 
      361004, China.
FAU - Huang, Yan-Ling
AU  - Huang YL
AD  - Department of Endocrinology, Zhongshan Hospital Xiamen University, 209 Hubin 
      South Road, Xiamen, Fujian 361004, China.
FAU - Zhang, Wen-Qiang
AU  - Zhang WQ
AD  - Department of Endocrinology, Zhongshan Hospital Xiamen University, 209 Hubin 
      South Road, Xiamen, Fujian 361004, China.
LA  - eng
PT  - Journal Article
DEP - 20140206
PL  - United States
TA  - ScientificWorldJournal
JT  - TheScientificWorldJournal
JID - 101131163
RN  - 0 (Adiponectin)
RN  - 0 (Receptors, Adiponectin)
RN  - 5W494URQ81 (Streptozocin)
SB  - IM
MH  - Adiponectin/*administration & dosage
MH  - Animals
MH  - Diabetes Mellitus, Type 2/chemically induced/*drug therapy/*metabolism
MH  - Diet, High-Fat
MH  - Dose-Response Relationship, Drug
MH  - Liver/drug effects/*metabolism
MH  - Male
MH  - Muscle, Skeletal/drug effects/metabolism
MH  - Non-alcoholic Fatty Liver Disease/chemically induced/*drug therapy/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Adiponectin/*metabolism
MH  - Streptozocin
MH  - Treatment Outcome
PMC - PMC3933409
EDAT- 2014/04/01 06:00
MHDA- 2014/12/19 06:00
PMCR- 2014/02/06
CRDT- 2014/04/01 06:00
PHST- 2013/08/31 00:00 [received]
PHST- 2013/12/24 00:00 [accepted]
PHST- 2014/04/01 06:00 [entrez]
PHST- 2014/04/01 06:00 [pubmed]
PHST- 2014/12/19 06:00 [medline]
PHST- 2014/02/06 00:00 [pmc-release]
AID - 10.1155/2014/230835 [doi]
PST - epublish
SO  - ScientificWorldJournal. 2014 Feb 6;2014:230835. doi: 10.1155/2014/230835. 
      eCollection 2014.