PMID- 24683508
OWN - NLM
STAT- MEDLINE
DCOM- 20151021
LR  - 20211021
IS  - 2162-3279 (Print)
IS  - 2162-3279 (Electronic)
VI  - 4
IP  - 2
DP  - 2014 Mar
TI  - Unilateral disruptions in the default network with aging in native space.
PG  - 143-57
LID - 10.1002/brb3.202 [doi]
AB  - BACKGROUND: Disruption of the default-mode network (DMN) in healthy elders has 
      been reported in many studies. METHODS: In a group of 51 participants (25 young, 
      26 elder) we examined DMN connectivity in subjects' native space. In the native 
      space method, subject-specific regional masks (obtained independently for each 
      subject) are used to extract regional fMRI times series. This approach 
      substitutes the spatial normalization and subsequent smoothing used in prevailing 
      methods, affords more accurate spatial localization, and provides the power to 
      examine connectivity separately in the two hemispheres instead of averaging 
      regions across hemispheres. RESULTS: The native space method yielded new findings 
      which were not detectable by the prevailing methods. The most reliable and robust 
      disruption in elders' DMN connectivity were found between supramarginal gyrus and 
      superior-frontal cortex in the right hemisphere only. The mean correlation 
      between these two regions in young participants was about 0.5, and dropped 
      significantly to 0.04 in elders (P = 2.1 x 10(-5)). In addition, the magnitude of 
      functional connectivity between these regions in the right hemisphere correlated 
      with memory (P = 0.05) and general fluid ability (P = 0.01) in elder participants 
      and with speed of processing in young participants (P = 0.008). These 
      relationships were not observed in the left hemisphere. CONCLUSION: These 
      findings suggest that analysis of DMN connectivity in subjects' native space can 
      improve localization and power and that it is important to examine connectivity 
      separately in each hemisphere.
FAU - Razlighi, Qolamreza R
AU  - Razlighi QR
AD  - Cognitive Neuroscience Division, Department of Neurology, Columbia University 
      College of Physicians and Surgeons New York, New York.
FAU - Habeck, Christian
AU  - Habeck C
AD  - Cognitive Neuroscience Division, Department of Neurology, Columbia University 
      College of Physicians and Surgeons New York, New York.
FAU - Steffener, Jason
AU  - Steffener J
AD  - Cognitive Neuroscience Division, Department of Neurology, Columbia University 
      College of Physicians and Surgeons New York, New York.
FAU - Gazes, Yunglin
AU  - Gazes Y
AD  - Cognitive Neuroscience Division, Department of Neurology, Columbia University 
      College of Physicians and Surgeons New York, New York.
FAU - Zahodne, Laura B
AU  - Zahodne LB
AD  - Cognitive Neuroscience Division, Department of Neurology, Columbia University 
      College of Physicians and Surgeons New York, New York.
FAU - Mackay-Brandt, Anna
AU  - Mackay-Brandt A
AD  - Cognitive Neuroscience Division, Department of Neurology, Columbia University 
      College of Physicians and Surgeons New York, New York.
FAU - Stern, Yaakov
AU  - Stern Y
AD  - Cognitive Neuroscience Division, Department of Neurology, Columbia University 
      College of Physicians and Surgeons New York, New York.
LA  - eng
GR  - K01 AG044467,/AG/NIA NIH HHS/United States
GR  - T32 MH020004/MH/NIMH NIH HHS/United States
GR  - K01 AG035061/AG/NIA NIH HHS/United States
GR  - R01 AG038465/AG/NIA NIH HHS/United States
GR  - R01 AG026158/AG/NIA NIH HHS/United States
GR  - K01 AG044467/AG/NIA NIH HHS/United States
GR  - T32 AG000261/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20131229
PL  - United States
TA  - Brain Behav
JT  - Brain and behavior
JID - 101570837
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aging/*physiology
MH  - Cerebral Cortex/*physiopathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Nerve Net/*physiopathology
MH  - Psychomotor Performance/*physiology
MH  - Young Adult
PMC - PMC3967531
OTO - NOTNLM
OT  - Age-related brain change
OT  - SPM
OT  - cognitive performance
OT  - fMRI analysis
OT  - interhemispheric averaging
OT  - resting-state BOLD fMRI
OT  - spatial normalization
EDAT- 2014/04/01 06:00
MHDA- 2014/04/01 06:01
PMCR- 2014/03/01
CRDT- 2014/04/01 06:00
PHST- 2013/08/08 00:00 [received]
PHST- 2013/11/01 00:00 [revised]
PHST- 2013/11/24 00:00 [accepted]
PHST- 2014/04/01 06:00 [entrez]
PHST- 2014/04/01 06:00 [pubmed]
PHST- 2014/04/01 06:01 [medline]
PHST- 2014/03/01 00:00 [pmc-release]
AID - 10.1002/brb3.202 [doi]
PST - ppublish
SO  - Brain Behav. 2014 Mar;4(2):143-57. doi: 10.1002/brb3.202. Epub 2013 Dec 29.