PMID- 24683520 OWN - NLM STAT- MEDLINE DCOM- 20151021 LR - 20211021 IS - 2162-3279 (Print) IS - 2162-3279 (Electronic) VI - 4 IP - 2 DP - 2014 Mar TI - BDNF Met66 modulates the cumulative effect of psychosocial childhood adversities on major depression in adolescents. PG - 290-7 LID - 10.1002/brb3.220 [doi] AB - BACKGROUND: The interplay among lifetime adversities and the genetic background has been previously examined on a variety of measures of depression; however, only few studies have focused on major depression disorder (MDD) in adolescence. METHODS: Using clinical data and DNA samples from mouthwash gathered from an epidemiological study on the prevalence of mental disorders in youths between 12 and 17 years old, we tested the statistical interaction between a set of psychosocial adversities experienced during childhood (CAs) with two common polymorphisms in the brain-derived neurotrophic factor (BDNF) (Val66Met) and SLC6A4 (L/S) genes on the probability of suffering MDD in adolescence. RESULTS: Genotype or allele frequencies for both polymorphisms were similar between groups of comparison (MDD N = 246; controls N = 270). The CAs factors: Abuse, neglect, and family dysfunctions; parental maladjustment, parental death, and to have experienced a life-threatening physical illness were predictors of clinical depression in adolescents. Remarkably, the cumulative number of psychosocial adversities was distinctly associated with an increase in the prevalence of depression but only in those Val/Val BDNF individuals; while the possession of at least a copy of the BDNF Met allele (i.e., Met +) was statistically linked with a "refractory" or resilient phenotype to the noticeable influence of CAs. CONCLUSION: Liability or resilience to develop MDD in adolescence is dependent of a complex interplay between particular environmental exposures and a set of plasticity genes including BDNF. A better understanding of these factors is important for developing better prevention and early intervention measures. FAU - Cruz-Fuentes, Carlos S AU - Cruz-Fuentes CS AD - Psychiatric Genetics Department, Clinical Research Branch, Instituto Nacional de Psiquiatria "Ramon de la Fuente Muniz" Mexico City, Mexico. FAU - Benjet, Corina AU - Benjet C AD - Epidemiology and Psychosocial Research Division, Instituto Nacional de Psiquiatria "Ramon de la Fuente Muniz" Mexico City, Mexico. FAU - Martinez-Levy, Gabriela A AU - Martinez-Levy GA AD - Psychiatric Genetics Department, Clinical Research Branch, Instituto Nacional de Psiquiatria "Ramon de la Fuente Muniz" Mexico City, Mexico. FAU - Perez-Molina, Amado AU - Perez-Molina A AD - Psychiatric Genetics Department, Clinical Research Branch, Instituto Nacional de Psiquiatria "Ramon de la Fuente Muniz" Mexico City, Mexico. FAU - Briones-Velasco, Magdalena AU - Briones-Velasco M AD - Psychiatric Genetics Department, Clinical Research Branch, Instituto Nacional de Psiquiatria "Ramon de la Fuente Muniz" Mexico City, Mexico. FAU - Suarez-Gonzalez, Jesus AU - Suarez-Gonzalez J AD - Psychiatric Genetics Department, Clinical Research Branch, Instituto Nacional de Psiquiatria "Ramon de la Fuente Muniz" Mexico City, Mexico. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140209 PL - United States TA - Brain Behav JT - Brain and behavior JID - 101570837 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (SLC6A4 protein, human) RN - 0 (Serotonin Plasma Membrane Transport Proteins) SB - IM MH - Adolescent MH - Brain-Derived Neurotrophic Factor/*genetics MH - Child MH - *Child Abuse MH - Depressive Disorder, Major/*etiology/*genetics MH - Female MH - *Gene-Environment Interaction MH - Humans MH - *Life Change Events MH - Male MH - *Resilience, Psychological MH - Serotonin Plasma Membrane Transport Proteins/genetics PMC - PMC3967543 OTO - NOTNLM OT - Adolescence OT - Mexican OT - brain-derived neurotrophic factor gene OT - childhood adversities OT - major depression OT - serotonin transporter gene EDAT- 2014/04/01 06:00 MHDA- 2014/04/01 06:01 PMCR- 2014/03/01 CRDT- 2014/04/01 06:00 PHST- 2013/07/30 00:00 [received] PHST- 2013/12/13 00:00 [revised] PHST- 2013/12/23 00:00 [accepted] PHST- 2014/04/01 06:00 [entrez] PHST- 2014/04/01 06:00 [pubmed] PHST- 2014/04/01 06:01 [medline] PHST- 2014/03/01 00:00 [pmc-release] AID - 10.1002/brb3.220 [doi] PST - ppublish SO - Brain Behav. 2014 Mar;4(2):290-7. doi: 10.1002/brb3.220. Epub 2014 Feb 9.