PMID- 24685092
OWN - NLM
STAT- MEDLINE
DCOM- 20141128
LR  - 20140401
IS  - 0253-3766 (Print)
IS  - 0253-3766 (Linking)
VI  - 36
IP  - 1
DP  - 2014 Jan
TI  - [Clinicopathological characteristics of colorectal cancer complicated with type 2 
      diabetes mellitus: analysis of clinicopathological data from 3, 202 colorectal 
      cancer patients].
PG  - 74-7
AB  - OBJECTIVE: the aim of this study was to determine the clinicopathological 
      characteristics of colorectal cancer (CRC) patients complicated with type 2 
      diabetes mellitus (T2DM ). METHODS: A total of 3, 202 patients with CRC confirmed 
      pathologically in Tianjin Union Medicine Center from January 2005 to December 
      2009 were included in this study. We analyzed the differences in 
      clinicopathological features between T2DM patients and non-diabetic patients 
      according to age of diagnosis, gender, tumor site, stage, gross type, 
      histological type, and differentiation. RESULTS: From 2005 to 2009, the number of 
      CRC patients increased yearly. The high incidence age of all CRC patients was 51 
      to 80 years old. The male to female ratio was 1.18:1, showing that the number of 
      female patients with CRC was increased significantly compared with males. The CRC 
      distribution of T2DM patients and non-diabetic patients showed a predominance of 
      rectal cancer (64.4%, 68.7%), followed by sigmoid colon cancer (12.5%, 13.0%), 
      and moderately differentiated ulcer-type adenocarcinoma. Compared with 
      non-diabetic patients, T2DM patients were older (66.2 years versus 62.7 years, P 
      < 0.001) and had more multiple CRCs (3.5% versus 1.6%, P < 0.001). Moreover, the 
      proportion of lymph node or organ metastasis in T2DM patients was higher than 
      that in non-diabetic patients (52.6% versus 45.6%, P < 0.05). No significant 
      differences were observed between both groups in terms of gender, gross type, 
      histological type, and differentiation(P > 0.05 for all). CONCLUSIONS: CRC 
      incidence shows an increasing trend with age. CRC patients with T2DM have an 
      older age of onset, higher proportion of lymph node and distant organ metastasis 
      than in non-diabetic patients.
FAU - Liu, Rui
AU  - Liu R
AD  - Tianjin Key Laboratory of Biomedical Detecting Techniques & Instruments, Tianjin 
      University, Tianjin 300072, China. Email: lr3595@163.com.
FAU - Hu, Liling
AU  - Hu L
FAU - Li, Gang
AU  - Li G
FAU - Zhao, Lizhong
AU  - Zhao L
FAU - Li, Sha
AU  - Li S
FAU - Zhang, Xipeng
AU  - Zhang X
FAU - Zhang, Qinghuai
AU  - Zhang Q
FAU - Wu, Lina
AU  - Wu L
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Zhong Liu Za Zhi
JT  - Zhonghua zhong liu za zhi [Chinese journal of oncology]
JID - 7910681
SB  - IM
MH  - Adenocarcinoma/complications/*pathology
MH  - Aged
MH  - Colorectal Neoplasms/complications/*pathology
MH  - *Diabetes Mellitus, Type 2
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2014/04/02 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/04/02 06:00
PHST- 2014/04/02 06:00 [entrez]
PHST- 2014/04/02 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
PST - ppublish
SO  - Zhonghua Zhong Liu Za Zhi. 2014 Jan;36(1):74-7.