PMID- 2468654
OWN - NLM
STAT- MEDLINE
DCOM- 19890526
LR  - 20190510
IS  - 0021-924X (Print)
IS  - 0021-924X (Linking)
VI  - 104
IP  - 6
DP  - 1988 Dec
TI  - Acute phase response of plasma proteins in analbuminemic rats.
PG  - 952-5
AB  - In healthy Nagase analbuminemic rats (NAR), the highest degree of relative 
      increase in serum protein concentration was found for alpha-2-macroglobulin, the 
      most prominent acute phase protein in rats. Its levels were about 30- and 60-fold 
      higher in males and females, respectively, than those in the control 
      Sprague-Dawley (SD) rats. In terms of absolute concentration, however, 
      alpha-1-inhibitor 3 (also called alpha-X-protein or murinoglobulin) showed the 
      most conspicuous change, its levels being higher by about 7 mg/ml than those in 
      SD. When the acute phase reaction was induced by subcutaneous injection of 
      turpentine, the levels of alpha-1- and alpha-2-macroglobulins, alpha-1-cysteine 
      proteinase inhibitor, alpha-1-antiproteinase, and alpha-1-inhibitor 3 in NAR 
      changed in essentially the same way as in SD: alpha-1-inhibitor 3 decreased 
      markedly while the rest increased further. These results suggest that mechanisms 
      responsible for the elevation of serum globulins in healthy NAR are not directly 
      related to those involved in the acute phase response. On the other hand, the 
      antithrombin III levels in healthy NAR were about twice the control values and 
      changed little during the inflammation. In contrast, this protein in SD doubled 
      during the acute phase, its maximal levels being close to those in healthy or 
      inflamed NAR. This suggests that the antithrombin III level in healthy NAR is 
      regulated by a mechanism similar to that in SD maximally reacting to the acute 
      phase stress.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Goto, K
AU  - Goto K
AD  - Department of Biochemistry, Kinki University School of Medicine, Osaka.
FAU - Saito, A
AU  - Saito A
FAU - Nagase, S
AU  - Nagase S
FAU - Sinohara, H
AU  - Sinohara H
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Biochem
JT  - Journal of biochemistry
JID - 0376600
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Blood Proteins)
RN  - 0 (Cysteine Proteinase Inhibitors)
RN  - 0 (Protease Inhibitors)
RN  - 0 (Serum Albumin)
RN  - 0 (Serum Globulins)
RN  - 0 (alpha 1-inhibitor 3)
RN  - 0 (alpha-Macroglobulins)
RN  - 0 (murinoglobulin)
RN  - 9000-94-6 (Antithrombin III)
SB  - IM
MH  - Acute-Phase Proteins/*metabolism
MH  - Animals
MH  - Antithrombin III/metabolism
MH  - Blood Proteins/*metabolism
MH  - Cysteine Proteinase Inhibitors
MH  - Female
MH  - Male
MH  - Protease Inhibitors/blood
MH  - Rats
MH  - Serum Albumin/*deficiency
MH  - Serum Globulins/metabolism
MH  - alpha-Macroglobulins/metabolism
EDAT- 1988/12/01 00:00
MHDA- 1988/12/01 00:01
CRDT- 1988/12/01 00:00
PHST- 1988/12/01 00:00 [pubmed]
PHST- 1988/12/01 00:01 [medline]
PHST- 1988/12/01 00:00 [entrez]
AID - 10.1093/oxfordjournals.jbchem.a122589 [doi]
PST - ppublish
SO  - J Biochem. 1988 Dec;104(6):952-5. doi: 10.1093/oxfordjournals.jbchem.a122589.