PMID- 24688467
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140401
LR  - 20211021
IS  - 1663-3563 (Print)
IS  - 1663-3563 (Electronic)
IS  - 1663-3563 (Linking)
VI  - 6
DP  - 2014
TI  - The BDNF effects on dendritic spines of mature hippocampal neurons depend on 
      neuronal activity.
PG  - 5
LID - 10.3389/fnsyn.2014.00005 [doi]
LID - 5
AB  - The fine tuning of neural networks during development and learning relies upon 
      both functional and structural plastic processes. Changes in the number as well 
      as in the size and shape of dendritic spines are associated to long-term 
      activity-dependent synaptic plasticity. However, the molecular mechanisms 
      translating functional into structural changes are still largely unknown. In this 
      context, neurotrophins, like Brain-Derived Neurotrophic Factor (BDNF), are among 
      promising candidates. Specifically BDNF-TrkB receptor signaling is crucial for 
      activity-dependent strengthening of synapses in different brain regions. BDNF 
      application has been shown to positively modulate dendritic and spine 
      architecture in cortical and hippocampal neurons as well as structural plasticity 
      in vitro. However, a global BDNF deprivation throughout the central nervous 
      system (CNS) resulted in very mild structural alterations of dendritic spines, 
      questioning the relevance of the endogenous BDNF signaling in modulating the 
      development and the mature structure of neurons in vivo. Here we show that a 
      loss-of-function approach, blocking BDNF results in a significant reduction in 
      dendritic spine density, associated with an increase in spine length and a 
      decrease in head width. These changes are associated with a decrease in F-actin 
      levels within spine heads. On the other hand, a gain-of-function approach, 
      applying exogenous BDNF, could not reproduce the increase in spine density or the 
      changes in spine morphology previously described. Taken together, we show here 
      that the effects exerted by BDNF on the dendritic architecture of hippocampal 
      neurons are dependent on the neuron's maturation stage. Indeed, in mature 
      hippocampal neurons in vitro as shown in vivo BDNF is specifically required for 
      the activity-dependent maintenance of the mature spine phenotype.
FAU - Kellner, Yves
AU  - Kellner Y
AD  - Division of Cellular Neurobiology, Zoological Institute, TU Braunschweig 
      Braunschweig, Germany.
FAU - Godecke, Nina
AU  - Godecke N
AD  - Division of Cellular Neurobiology, Zoological Institute, TU Braunschweig 
      Braunschweig, Germany.
FAU - Dierkes, Tobias
AU  - Dierkes T
AD  - Division of Cellular Neurobiology, Zoological Institute, TU Braunschweig 
      Braunschweig, Germany.
FAU - Thieme, Nils
AU  - Thieme N
AD  - Division of Cellular Neurobiology, Zoological Institute, TU Braunschweig 
      Braunschweig, Germany.
FAU - Zagrebelsky, Marta
AU  - Zagrebelsky M
AD  - Division of Cellular Neurobiology, Zoological Institute, TU Braunschweig 
      Braunschweig, Germany.
FAU - Korte, Martin
AU  - Korte M
AD  - Division of Cellular Neurobiology, Zoological Institute, TU Braunschweig 
      Braunschweig, Germany.
LA  - eng
PT  - Journal Article
DEP - 20140320
PL  - Switzerland
TA  - Front Synaptic Neurosci
JT  - Frontiers in synaptic neuroscience
JID - 101548972
PMC - PMC3960490
OTO - NOTNLM
OT  - dendrites
OT  - hippocampus
OT  - neurotrophins
OT  - spines
OT  - structural plasticity
EDAT- 2014/04/02 06:00
MHDA- 2014/04/02 06:01
PMCR- 2014/01/01
CRDT- 2014/04/02 06:00
PHST- 2013/12/16 00:00 [received]
PHST- 2014/03/01 00:00 [accepted]
PHST- 2014/04/02 06:00 [entrez]
PHST- 2014/04/02 06:00 [pubmed]
PHST- 2014/04/02 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fnsyn.2014.00005 [doi]
PST - epublish
SO  - Front Synaptic Neurosci. 2014 Mar 20;6:5. doi: 10.3389/fnsyn.2014.00005. 
      eCollection 2014.