PMID- 24688780
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 2072-1439 (Print)
IS  - 2077-6624 (Electronic)
IS  - 2072-1439 (Linking)
VI  - 6
IP  - 4
DP  - 2014 Apr
TI  - Combining targeted agents and hypo- and hyper-fractionated radiotherapy in NSCLC.
PG  - 356-68
LID - 10.3978/j.issn.2072-1439.2013.12.05 [doi]
AB  - Radical radiotherapy remains the cornerstone of treatment for patients with 
      unresectable locally advanced non small cell lung cancer (NSCLC) either as single 
      modality treatment for poor performance status patients or with sequential or 
      concomitant chemotherapy for good performance status patients. Advances in 
      understanding of tumour molecular biology, targeted drug development and 
      experiences of novel agents in the advanced disease setting have brought targeted 
      agents into the NSCLC clinic. In parallel experience using modified accelerated 
      fractionation schedules in locally advanced disease have demonstrated improved 
      outcomes compared to conventional fractionation in the single modality and 
      sequential chemo-radiotherapy settings. Early studies of targeted agents combined 
      with (chemo-) radiotherapy in locally advanced disease in different clinical 
      settings are discussed below and important areas for future studies are 
      high-lighted.
FAU - McDonald, Fiona
AU  - McDonald F
AD  - The Royal Marsden NHS Foundation Trust, UK.
FAU - Popat, Sanjay
AU  - Popat S
AD  - The Royal Marsden NHS Foundation Trust, UK.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - China
TA  - J Thorac Dis
JT  - Journal of thoracic disease
JID - 101533916
PMC - PMC3968557
OTO - NOTNLM
OT  - Non small cell lung cancer (NSCLC)
OT  - modified fractionation
OT  - radical radiotherapy
OT  - targeted agents
EDAT- 2014/04/02 06:00
MHDA- 2014/04/02 06:01
PMCR- 2014/04/01
CRDT- 2014/04/02 06:00
PHST- 2013/09/02 00:00 [received]
PHST- 2013/12/03 00:00 [accepted]
PHST- 2014/04/02 06:00 [entrez]
PHST- 2014/04/02 06:00 [pubmed]
PHST- 2014/04/02 06:01 [medline]
PHST- 2014/04/01 00:00 [pmc-release]
AID - jtd-06-04-356 [pii]
AID - 10.3978/j.issn.2072-1439.2013.12.05 [doi]
PST - ppublish
SO  - J Thorac Dis. 2014 Apr;6(4):356-68. doi: 10.3978/j.issn.2072-1439.2013.12.05.