PMID- 24689450
OWN - NLM
STAT- MEDLINE
DCOM- 20150519
LR  - 20140423
IS  - 1447-0756 (Electronic)
IS  - 1341-8076 (Linking)
VI  - 40
IP  - 5
DP  - 2014 May
TI  - Recurrent miscarriage is associated with a decline of decidual natural killer 
      cells expressing killer cell immunoglobulin-like receptors specific for human 
      leukocyte antigen C.
PG  - 1288-95
LID - 10.1111/jog.12329 [doi]
AB  - AIM: To investigate the relationship between natural killer (NK) cell phenotype 
      and recurrent miscarriage (RM). METHODS: We studied killer cell 
      immunoglobulin-like receptor (KIR) expression on decidual NK cells in women with 
      RM. RESULTS: The expression of KIR2DL1/S1 on CD56(+) CD16(-) NK cells in the 
      deciduas of these women was significantly lower than in that of control subjects 
      (P = 0.026). There was a significant decline in the frequency of CD56(+) CD16(-) 
      NK cells staining for KIR2DL1/S1 and KIR2DL2/S2/L3 throughout the first trimester 
      in patients (P < 0.05). Furthermore, by stratification of the women in three 
      groups according to gestational stage, it was found that KIR2DL1/S1 expressing NK 
      cells were significantly decreased in all groups, especially around gestational 
      days 50-70 (P = 0.010). CONCLUSION: This is the first report to demonstrate that 
      RM is associated with a decline in the frequency of decidual NK cells expressing 
      KIR specific for human leukocyte antigen (HLA)-C, and in which gestational stage 
      was considered. The results suggest that KIR phenotype contributes to the 
      pathogenesis of the disease, and that assessment of KIR may serve as a diagnostic 
      tool.
CI  - (c) 2014 The Authors. Journal of Obstetrics and Gynaecology Research (c) 2014 Japan 
      Society of Obstetrics and Gynecology.
FAU - Wang, Shan
AU  - Wang S
AD  - Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to 
      Shandong University, Jinan, China.
FAU - Li, Yan-Ping
AU  - Li YP
FAU - Ding, Bo
AU  - Ding B
FAU - Zhao, Yue-Ran
AU  - Zhao YR
FAU - Chen, Zi-Jiang
AU  - Chen ZJ
FAU - Xu, Cheng-Yan
AU  - Xu CY
FAU - Fu, Yi-Bing
AU  - Fu YB
FAU - Wang, Xie-Tong
AU  - Wang XT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140402
PL  - Australia
TA  - J Obstet Gynaecol Res
JT  - The journal of obstetrics and gynaecology research
JID - 9612761
RN  - 0 (HLA-C Antigens)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Abortion, Habitual/*etiology/immunology
MH  - Adult
MH  - Decidua/*immunology
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - Gestational Age
MH  - HLA-C Antigens/*metabolism
MH  - Humans
MH  - Immunophenotyping
MH  - Killer Cells, Natural/*immunology
MH  - Pregnancy
MH  - Receptors, KIR/*analysis
OTO - NOTNLM
OT  - decidua
OT  - human
OT  - killer cell immunoglobulin-like receptor
OT  - natural killer cells
OT  - recurrent miscarriage
EDAT- 2014/04/03 06:00
MHDA- 2015/05/20 06:00
CRDT- 2014/04/03 06:00
PHST- 2013/02/05 00:00 [received]
PHST- 2013/10/12 00:00 [accepted]
PHST- 2014/04/03 06:00 [entrez]
PHST- 2014/04/03 06:00 [pubmed]
PHST- 2015/05/20 06:00 [medline]
AID - 10.1111/jog.12329 [doi]
PST - ppublish
SO  - J Obstet Gynaecol Res. 2014 May;40(5):1288-95. doi: 10.1111/jog.12329. Epub 2014 
      Apr 2.