PMID- 24691009
OWN - NLM
STAT- MEDLINE
DCOM- 20150827
LR  - 20181202
IS  - 0301-0430 (Print)
IS  - 0301-0430 (Linking)
VI  - 83
IP  - 3
DP  - 2015 Mar
TI  - Prescription-medication sharing among family members: an unrecognized cause of a 
      serious drug adverse event in a patient with impaired renal function.
PG  - 196-200
LID - 10.5414/CN108052 [doi]
AB  - Many medications need to be avoided in chronic kidney disease (CKD) because of 
      increased toxicity. Metformin - an oral hypoglycemic drug universally recommended 
      as the first-line treatment for type 2 diabetes mellitus (T2DM) - undergoes 
      significant accumulation in advanced CKD that may ultimately lead to lactic 
      acidosis. Recently, it has been found that side effects of the therapy may 
      occasionally neither be linked to improper prescription nor lack of dose 
      adjustment by the physician, but can result from borrowing and sharing of drugs 
      with relatives and friends. This poorly recognized problem has never been studied 
      in renal patients. This work contains a discussion on the diagnostic problems 
      associated with proper diagnosis of the etiology of severe acidosis in an elderly 
      woman with advanced CKD and diabetes. The patient developed severe lactic 
      acidosis by taking metformin that was prescribed by another doctor to her son, 
      who was also diabetic. The diagnosis of lactic acidosis was delayed since the 
      initial laboratory assessments had focused mostly on dehydration and substance 
      abuse.
FAU - Makowka, Agnieszka
AU  - Makowka A
FAU - Zawiasa, Anna
AU  - Zawiasa A
FAU - Nowicki, Michal
AU  - Nowicki M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Germany
TA  - Clin Nephrol
JT  - Clinical nephrology
JID - 0364441
RN  - 0 (Hypoglycemic Agents)
RN  - 9100L32L2N (Metformin)
SB  - IM
MH  - Acidosis, Lactic/chemically induced
MH  - Aged
MH  - Diabetes Mellitus, Type 2/complications/*drug therapy
MH  - Diabetic Nephropathies/*physiopathology
MH  - Drug-Related Side Effects and Adverse Reactions/*etiology
MH  - Family
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - Hypoglycemic Agents/*adverse effects
MH  - Metformin/*adverse effects
MH  - Renal Insufficiency, Chronic/*physiopathology
EDAT- 2014/04/03 06:00
MHDA- 2015/08/28 06:00
CRDT- 2014/04/03 06:00
PHST- 2015/02/13 00:00 [accepted]
PHST- 2014/04/03 06:00 [entrez]
PHST- 2014/04/03 06:00 [pubmed]
PHST- 2015/08/28 06:00 [medline]
AID - 11336 [pii]
AID - 10.5414/CN108052 [doi]
PST - ppublish
SO  - Clin Nephrol. 2015 Mar;83(3):196-200. doi: 10.5414/CN108052.