PMID- 24691430
OWN - NLM
STAT- MEDLINE
DCOM- 20140922
LR  - 20220408
IS  - 2041-1723 (Electronic)
IS  - 2041-1723 (Linking)
VI  - 5
DP  - 2014 Apr 1
TI  - Caloric restriction reduces age-related and all-cause mortality in rhesus 
      monkeys.
PG  - 3557
LID - 10.1038/ncomms4557 [doi]
LID - 3557
AB  - Caloric restriction (CR) without malnutrition increases longevity and delays the 
      onset of age-associated disorders in short-lived species, from unicellular 
      organisms to laboratory mice and rats. The value of CR as a tool to understand 
      human ageing relies on translatability of CR's effects in primates. Here we show 
      that CR significantly improves age-related and all-cause survival in monkeys on a 
      long-term ~30% restricted diet since young adulthood. These data contrast with 
      observations in the 2012 NIA intramural study report, where a difference in 
      survival was not detected between control-fed and CR monkeys. A comparison of 
      body weight of control animals from both studies with each other, and against 
      data collected in a multi-centred relational database of primate ageing, suggests 
      that the NIA control monkeys were effectively undergoing CR. Our data indicate 
      that the benefits of CR on ageing are conserved in primates.
FAU - Colman, Ricki J
AU  - Colman RJ
AD  - Wisconsin National Primate Research Center, University of Wisconsin, Madison, 
      Wisconsin 53715, USA.
FAU - Beasley, T Mark
AU  - Beasley TM
AD  - 1] Geriatrics Research, Education and Clinical Center, Birmingham/Atlanta 
      Veterans Administration Hospital, Birmingham, Alabama 35233, USA [2] Department 
      of Biostatistics, University of Alabama, Birmingham, Alabama 35294, USA.
FAU - Kemnitz, Joseph W
AU  - Kemnitz JW
AD  - Department of Cell and Regenerative Biology, University of Wisconsin, Madison, 
      Wisconsin 53706, USA.
FAU - Johnson, Sterling C
AU  - Johnson SC
AD  - 1] Geriatrics Research, Education and Clinical Center, William S. Middleton 
      Memorial Veterans Hospital, Madison, Wisconsin 53705, USA [2] Department of 
      Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA.
FAU - Weindruch, Richard
AU  - Weindruch R
AD  - 1] Geriatrics Research, Education and Clinical Center, William S. Middleton 
      Memorial Veterans Hospital, Madison, Wisconsin 53705, USA [2] Department of 
      Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA.
FAU - Anderson, Rozalyn M
AU  - Anderson RM
AD  - 1] Geriatrics Research, Education and Clinical Center, William S. Middleton 
      Memorial Veterans Hospital, Madison, Wisconsin 53705, USA [2] Department of 
      Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA.
LA  - eng
GR  - P51 RR000167/RR/NCRR NIH HHS/United States
GR  - R01 AG037000/AG/NIA NIH HHS/United States
GR  - P01 AG011915/AG/NIA NIH HHS/United States
GR  - P51 OD011106/OD/NIH HHS/United States
GR  - P50 AG033514/AG/NIA NIH HHS/United States
GR  - R01 AG040178/AG/NIA NIH HHS/United States
GR  - P51 RR000167/P51 OD011106/OD/NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140401
PL  - England
TA  - Nat Commun
JT  - Nature communications
JID - 101528555
SB  - IM
MH  - Aging/*metabolism
MH  - Animals
MH  - Body Weight
MH  - *Caloric Restriction
MH  - Disease Models, Animal
MH  - Female
MH  - Humans
MH  - Longevity
MH  - Macaca mulatta
MH  - Male
MH  - *Mortality
MH  - Survival Analysis
PMC - PMC3988801
EDAT- 2014/04/03 06:00
MHDA- 2014/09/23 06:00
CRDT- 2014/04/03 06:00
PHST- 2013/10/12 00:00 [received]
PHST- 2014/03/05 00:00 [accepted]
PHST- 2014/04/03 06:00 [entrez]
PHST- 2014/04/03 06:00 [pubmed]
PHST- 2014/09/23 06:00 [medline]
AID - ncomms4557 [pii]
AID - 10.1038/ncomms4557 [doi]
PST - epublish
SO  - Nat Commun. 2014 Apr 1;5:3557. doi: 10.1038/ncomms4557.