PMID- 24692125
OWN - NLM
STAT- MEDLINE
DCOM- 20140623
LR  - 20220321
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 55
IP  - 5
DP  - 2014 May 2
TI  - Structure-function relationships with spectral-domain optical coherence 
      tomography retinal nerve fiber layer and optic nerve head measurements.
PG  - 2953-62
LID - 10.1167/iovs.13-13482 [doi]
AB  - PURPOSE: To evaluate the regional structure-function relationship between visual 
      field sensitivity and retinal nerve fiber layer (RNFL) thickness and optic nerve 
      head (ONH) measurements using spectral-domain optical coherence tomography 
      (SD-OCT). METHODS: Prospective cross-sectional study conducted on patients with 
      glaucoma, suspected glaucoma, and healthy subjects. Eyes were tested on Cirrus 
      OCT and standard achromatic perimetry. RNFL thickness of 12 peripapillary 30 degrees  
      sectors, neuroretinal rim thickness extracted from 36 neuroretinal rim scans, and 
      Bruch membrane opening minimum rim width (BMO-MRW)-a recently defined 
      parameter-extracted from 36 neuroretinal rim scans were obtained. Correlations 
      between peripapillary RNFL thickness, neuroretinal rim thickness, all six sectors 
      of BMO-MRW, and visual field sensitivity in the six corresponding areas were 
      evaluated using logarithmic regression analysis. Receiver operating curve areas 
      were calculated for each RNFL, ONH, and macular ganglion cell analysis parameter. 
      RESULTS: We included 142 eyes of 142 subjects. The correlations (r(2)) between 
      RNFL thickness, Cirrus-based neuroretinal rim thickness, BMO-MRW and visual field 
      sensitivity ranged from 0.07 to 0.60, 0.15 to 0.49, and 0.24 to 0.66, 
      respectively. The structure-function correlations were stronger with BMO-MRW than 
      with Cirrus-based neuroretinal rim thickness. The largest areas under the 
      receiver operating curve were seen for rim area (0.926 [95% confidence interval 
      0.875, 0.977]; P < 0.001) in eyes with glaucoma and for average RNFL (0.863 
      [0.769, 0.957]; P < 0.01) in eyes with suspected glaucoma. CONCLUSIONS: The 
      structure-function relationship was significantly stronger with BMO-MRW than 
      other ONH SD-OCT parameters. The best diagnostic capabilities were seen with rim 
      area and average RNFL.
FAU - Pollet-Villard, Frederic
AU  - Pollet-Villard F
AD  - Department of Ophthalmology, University Hospital, CHU Grenoble, Grenoble, France.
FAU - Chiquet, Christophe
AU  - Chiquet C
FAU - Romanet, Jean-Paul
AU  - Romanet JP
FAU - Noel, Christian
AU  - Noel C
FAU - Aptel, Florent
AU  - Aptel F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140502
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Cross-Sectional Studies
MH  - Female
MH  - Glaucoma/*diagnosis/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Optic Disk/*pathology
MH  - Prospective Studies
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Fields/physiology
OTO - NOTNLM
OT  - glaucoma
OT  - optical coherence tomography
OT  - structure-function
OT  - visual field
EDAT- 2014/04/03 06:00
MHDA- 2014/06/24 06:00
CRDT- 2014/04/03 06:00
PHST- 2014/04/03 06:00 [entrez]
PHST- 2014/04/03 06:00 [pubmed]
PHST- 2014/06/24 06:00 [medline]
AID - iovs.13-13482 [pii]
AID - 10.1167/iovs.13-13482 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2014 May 2;55(5):2953-62. doi: 10.1167/iovs.13-13482.