PMID- 24692374
OWN - NLM
STAT- MEDLINE
DCOM- 20150122
LR  - 20211021
IS  - 1757-790X (Electronic)
IS  - 1757-790X (Linking)
VI  - 2014
DP  - 2014 Apr 1
TI  - ANCA-associated vasculitis and pauci-immune glomerulonephritis in HIV disease.
LID - 10.1136/bcr-2013-202423 [doi]
LID - bcr2013202423
AB  - We report the case of a 51-year-old African woman with longstanding 
      well-controlled HIV who developed relapsing systemic antineutrophil cytoplasm 
      antibody (ANCA)-associated vasculitis and glomerulonephritis. She presented with 
      an acute kidney injury and heavy proteinuria in the setting of a prolonged 
      history of diffuse arthralgias and transient ocular symptoms. Antimyeloperoxidase 
      (MPO) antibody titre was >100 IU/mL. Subsequent renal biopsy demonstrated a focal 
      necrotising pauci-immune glomerulonephritis and a diagnosis of 
      MPO-ANCA-associated microscopic polyangiitis was made. The patient was treated 
      with tapering glucocorticoids and rituximab with resolution of her acute kidney 
      injury and reduction in her proteinuria. Treatment was complicated by the 
      development of steroid-induced diabetes and one mild clinical relapse, but was 
      otherwise well tolerated without infectious complications or deterioration in her 
      HIV disease.
FAU - Evans, Rhys
AU  - Evans R
AD  - UCL Centre for Nephrology, London, UK.
FAU - Gueret-Wardle, Alexander
AU  - Gueret-Wardle A
FAU - Edwards, Simon
AU  - Edwards S
FAU - Salama, Alan
AU  - Salama A
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20140401
PL  - England
TA  - BMJ Case Rep
JT  - BMJ case reports
JID - 101526291
SB  - IM
MH  - Acute Kidney Injury/*etiology
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/*complications/drug 
      therapy
MH  - Female
MH  - Glomerulonephritis/*complications/drug therapy
MH  - HIV Infections/*complications
MH  - Humans
MH  - Middle Aged
PMC - PMC3987218
EDAT- 2014/04/03 06:00
MHDA- 2015/01/23 06:00
PMCR- 2016/04/01
CRDT- 2014/04/03 06:00
PHST- 2014/04/03 06:00 [entrez]
PHST- 2014/04/03 06:00 [pubmed]
PHST- 2015/01/23 06:00 [medline]
PHST- 2016/04/01 00:00 [pmc-release]
AID - bcr-2013-202423 [pii]
AID - 10.1136/bcr-2013-202423 [doi]
PST - epublish
SO  - BMJ Case Rep. 2014 Apr 1;2014:bcr2013202423. doi: 10.1136/bcr-2013-202423.