PMID- 24692782
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140402
LR  - 20211021
IS  - 0011-393X (Print)
IS  - 0011-393X (Linking)
VI  - 69
IP  - 1
DP  - 2008 Feb
TI  - Pharmacokinetics and postoperative analgesia of epidural tramadol: A prospective, 
      pilot study.
PG  - 49-55
LID - 10.1016/j.curtheres.2008.02.006 [doi]
AB  - BACKGROUND: Tramadol, a centrally acting analgesic drug, can be administered via 
      multiple routes and is generally well tolerated. OBJECTIVE: This study was 
      designed to assess the pharmacokinetics of epidural tramadol administered 
      preoperatively in Japanese patients undergoing upper abdominal surgery. METHOD: 
      Japanese patients who were scheduled to undergo upper abdominal surgery in The 
      Kitasato Institute Hospital, Tokyo, Japan, were included. Patients received 
      tramadol 2 mg/kg with 5 mL of 1% mepivacaine epidurally 10 minutes before 
      incision. The serum concentration of tramadol was determined by high-performance 
      liquid chromatography for 21 hours after administration. Serum concentration was 
      determined before tramadol administration and 10, 20, 30, and 60 minutes after 
      tramadol administration, first postoperative night, and first postoperative day. 
      Pain score and adverse events (AEs) were assessed at 1, 3, 6, 12, 18, 24, 36, and 
      48 hours after surgery by patient interview. RESULTS: Eleven patients were 
      assessed for enrollment. Seven patients (6 men, 1 woman; mean [SD] age, 61.3 
      [12.6] years; mean [SD] weight, 59.9 [8.9] kg) provided consent and completed the 
      study. The mean (SD) serum Cmax of tramadol was 1385.5 (390.8) ng/mL, Tmax was 
      0.33 (0.22) hour, and terminal elimination half-life (t1/2beta) was 10.5 (2.3) 
      hours. Four patients complained of nausea; however, only 1 patient was 
      administered an antiemetic. No other AEs were reported. CONCLUSION: This pilot 
      study found that epidural tramadol administered before incision induced a Cmax 
      within 30 minutes of administration. The drug was detected in serum at  approximately 21 hours 
      after surgery.
FAU - Kubota, Rie
AU  - Kubota R
AD  - Division of Clinical Pharmacy, Center for Clinical Pharmacy and Clinical 
      Sciences, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
FAU - Komiyama, Takako
AU  - Komiyama T
AD  - Division of Clinical Pharmacy, Center for Clinical Pharmacy and Clinical 
      Sciences, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
FAU - Miwa, Yasuko
AU  - Miwa Y
AD  - Department of Anaesthesia, The Kitasato Institute Hospital, Tokyo, Japan.
FAU - Ide, Takayuki
AU  - Ide T
AD  - Division of Clinical Pharmacy, Center for Clinical Pharmacy and Clinical 
      Sciences, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
FAU - Toyoda, Hajime
AU  - Toyoda H
AD  - Department of Surgery, The Kitasato Institute Hospital, Tokyo, Japan.
FAU - Asanuma, Fumiki
AU  - Asanuma F
AD  - Department of Surgery, The Kitasato Institute Hospital, Tokyo, Japan.
FAU - Yamada, Yoshinori
AU  - Yamada Y
AD  - Department of Surgery, The Kitasato Institute Hospital, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Curr Ther Res Clin Exp
JT  - Current therapeutic research, clinical and experimental
JID - 0372621
PMC - PMC3969952
OTO - NOTNLM
OT  - epidural
OT  - pharmacokinetics
OT  - tramadol
EDAT- 2008/02/01 00:00
MHDA- 2008/02/01 00:01
PMCR- 2008/02/01
CRDT- 2014/04/03 06:00
PHST- 2007/10/03 00:00 [accepted]
PHST- 2014/04/03 06:00 [entrez]
PHST- 2008/02/01 00:00 [pubmed]
PHST- 2008/02/01 00:01 [medline]
PHST- 2008/02/01 00:00 [pmc-release]
AID - S0011-393X(08)00021-0 [pii]
AID - 10.1016/j.curtheres.2008.02.006 [doi]
PST - ppublish
SO  - Curr Ther Res Clin Exp. 2008 Feb;69(1):49-55. doi: 
      10.1016/j.curtheres.2008.02.006.