PMID- 24692798
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140402
LR  - 20220410
IS  - 0011-393X (Print)
IS  - 0011-393X (Linking)
VI  - 69
IP  - 3
DP  - 2008 Jun
TI  - Antihypertensive effect of barnidipine 10 mg or amlodipine 5 to 10 mg once daily 
      in treatment-naive patients with essential hypertension: A 24-week, randomized, 
      open-label, pilot study.
PG  - 192-206
LID - 10.1016/j.curtheres.2008.06.002 [doi]
AB  - BACKGROUND: Dihydropyridine calcium antagonists are largely employed for the 
      treatment of hypertension, coronary heart disease, and heart failure. OBJECTIVE: 
      The aim of our study was to compare the antihypertensive effect of the 
      dihydropyridine calcium antagonists barnidipine and amlodipine. METHODS: This was 
      a 24-week, randomized, open-label, pilot study. Consecutive treatment-naive 
      patients with grade I or II essential hypertension (office sitting systolic blood 
      pressure [BP] of 140-179 mm Hg and diastolic BP of 90-109 mm Hg) were enrolled. 
      The primary end points were the effect of treatment with either barnidipine 10 mg 
      or amlodipine 5 mg once daily on office and ambulatory BP, left ventricular mass 
      index (LVMI), and markers of cardiac damage, serum procollagen type I C-terminal 
      propeptide, and plasma amino-terminal pro-B-type natriuretic peptide 
      concentrations. Patients were assessed at enrollment, and 12 and 24 weeks. During 
      each visit, the prevalence of adverse events (AEs) was also monitored using 
      spontaneous reporting, patient interview, and physical examination, the 
      relationship to study drug being determined by the investigators. Compliance with 
      treatment was assessed at each study visit by counting returned tablets. RESULTS: 
      Thirty eligible patients (20 men, 10 women; mean [SD] age, 47 [12] years) were 
      included in the study; all patients completed the 24 weeks of study treatment. 
      Twelve weeks after randomization, 6 patients in the amlodipine group had their 
      dose doubled to 10 mg due to inadequate BP control. Mean BP reductions at study 
      end were not significantly different between the barnidipine and amlodipine 
      groups (office BP, -10.3/-9.4 vs -16.6/-9.1 mm Hg; ambulatory BP, 9.4/6.4 vs 
      8.1/5.1 mm Hg). Reductions in LVMI and markers of cardiac damage were not 
      significantly different between the 2 groups. Significantly more patients in the 
      amlodipine group reported drug-related AEs compared with those in the barnidipine 
      group (9 [60%] vs 2 [13%]; P < 0.05). CONCLUSION: In this small sample of 
      treatment-naive hypertensive patients, the antihypertensive effect of barnidipine 
      10 mg once daily was not significantly different from that of amlodipine 5 to 10 
      mg once daily.
FAU - Rossetti, Giuseppe
AU  - Rossetti G
AD  - UOC I Cardiologia, Azienda di Servizi alla Persona, Istituti Milanesi Martinitt e 
      Stelline e Pio Albergo Trivulzio, Universita di Milano, Milano, Italy.
FAU - Pizzocri, Samuele
AU  - Pizzocri S
AD  - UOC I Cardiologia, Azienda di Servizi alla Persona, Istituti Milanesi Martinitt e 
      Stelline e Pio Albergo Trivulzio, Universita di Milano, Milano, Italy.
FAU - Brasca, Francesco
AU  - Brasca F
AD  - UOC I Cardiologia, Azienda di Servizi alla Persona, Istituti Milanesi Martinitt e 
      Stelline e Pio Albergo Trivulzio, Universita di Milano, Milano, Italy.
FAU - Pozzi, Marta
AU  - Pozzi M
AD  - UOC I Cardiologia, Azienda di Servizi alla Persona, Istituti Milanesi Martinitt e 
      Stelline e Pio Albergo Trivulzio, Universita di Milano, Milano, Italy.
FAU - Beltrami, Laura M
AU  - Beltrami LM
AD  - UOC I Cardiologia, Azienda di Servizi alla Persona, Istituti Milanesi Martinitt e 
      Stelline e Pio Albergo Trivulzio, Universita di Milano, Milano, Italy.
FAU - Bolla, Giovanni B
AU  - Bolla GB
AD  - Centro Interuniversitario di Fisiologia Clinica e Ipertensione, IRCCS 
      Policlinico, Universita di Milano, Milano, Italy.
FAU - Famiani, Roberta
AU  - Famiani R
AD  - UOC I Cardiologia, Azienda di Servizi alla Persona, Istituti Milanesi Martinitt e 
      Stelline e Pio Albergo Trivulzio, Universita di Milano, Milano, Italy.
FAU - Caimi, Barbara
AU  - Caimi B
AD  - UOC I Cardiologia, Azienda di Servizi alla Persona, Istituti Milanesi Martinitt e 
      Stelline e Pio Albergo Trivulzio, Universita di Milano, Milano, Italy.
FAU - Omboni, Stefano
AU  - Omboni S
AD  - Instituto Italiano di Telemedicina, Varese, Italy.
FAU - Magrini, Fabio
AU  - Magrini F
AD  - Centro Interuniversitario di Fisiologia Clinica e Ipertensione, IRCCS 
      Policlinico, Universita di Milano, Milano, Italy.
FAU - Carugo, Stefano
AU  - Carugo S
AD  - UOC I Cardiologia, Azienda di Servizi alla Persona, Istituti Milanesi Martinitt e 
      Stelline e Pio Albergo Trivulzio, Universita di Milano, Milano, Italy.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Curr Ther Res Clin Exp
JT  - Current therapeutic research, clinical and experimental
JID - 0372621
EIN - Curr Ther Res Clin Exp. 2008 Aug;69(4):378-9
PMC - PMC3969966
OTO - NOTNLM
OT  - ambulatory bloodpressure monitoring
OT  - amlodipine
OT  - barnidipine
OT  - essential hypertension
OT  - left ventricular mass index
OT  - smoothness index
EDAT- 2008/06/01 00:00
MHDA- 2008/06/01 00:01
PMCR- 2008/06/01
CRDT- 2014/04/03 06:00
PHST- 2008/02/22 00:00 [accepted]
PHST- 2014/04/03 06:00 [entrez]
PHST- 2008/06/01 00:00 [pubmed]
PHST- 2008/06/01 00:01 [medline]
PHST- 2008/06/01 00:00 [pmc-release]
AID - S0011-393X(08)00055-6 [pii]
AID - 10.1016/j.curtheres.2008.06.002 [doi]
PST - ppublish
SO  - Curr Ther Res Clin Exp. 2008 Jun;69(3):192-206. doi: 
      10.1016/j.curtheres.2008.06.002.